Protein Alignment HSPH1 and Grp170

DIOPT Version :10

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 888
• Identity: 249/888 - (28%)
• Similarity: 404/888 - (45%)
• Gaps: 122/888 - (13%)

Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLS-YDLV--PLKNGG 100
            ::::|....||||..|:...|...|:.........|:..::|.:...::... |::|  |.:|
  Fly    57 AILAFRDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERN-- 119

Human   101 VGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIV 165
              ..|....:...||||::.|.||.|.|:.|:.|:::|:|:||::||.:|..|||.::|.|||:.
  Fly   120 --TVVFRKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLA 182

Human   166 GLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFN----KGK----- 221
            .|..|:|:||..|||||||::.:.  .::|..:..:|.|||  |::.||...:    |.|
  Fly   183 NLKVLQLINDYAAVALNYGVFHRG--EINETAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREI 243

Human   222 ---LKVLGTAFDPFLGGKNFDEKLVEHFCAEFKT--KYKLDAKSKIRALLRLYQECEKLKKLMSS 281
               ::|||..:|..|||.....:|.::...||..  |.|.|..:..|||.:|::|..:||.::|:
  Fly   244 NPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSA 308

Human   282 NSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGA 346
            | |:....||..:.|.|....:.|.:.|:||.:|..:...||...|..:||.::.::.|.:.||.
  Fly   309 N-TEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGG 372

Human   347 TRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHD 411
            ||:|.|:|.|.....:::...|||||:...|...:.|.||..|||::|.|.||..||:.:.:..|
  Fly   373 TRVPRVQETIKAVIKQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERD 437

Human   412 SEDTEGVHEV----FSRNHAAPFSKVLTFLRR-GPFELEAFYSDPQGVPYPE-AKIGRFVVQNVS 470
            ..|...|.:|    |:..:..|..||:||.:. ..||....|:|.......| |.:|...|..|.
  Fly   438 PGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQ 502

Human   471 AQKDG---EKSR--------VKVKVRVNTHGIFTISTASMV-EKVPTEENEMSSEADMECLNQRP 523
            .::..   |||:        :|....::..|||..:....| ||                  |:|
  Fly   503 LKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEK------------------QKP 549

Human   524 PENPDTDKNV-----------------QQDNSE------AGTQPQVQTDAQQTSQSPPSPELTSE 565
            .::.|.|..:                 ::||||      ||.:|....|.::..:...|.|..||
  Fly   550 EDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSE 614

Human   566 ENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLL-NMYIETEGKMIMQDKL 629
            |:            ..|..|||...||:|.|:.|:......|....|: :.|.::..|:...:|.
  Fly   615 ES------------TKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKA 667

Human   630 EKER---NDAKNAVEEYVYEFRDKLC-GPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAY 690
            |::|   ..|.||:|.::.|.:.||. ..|.|....::.:..|...:...:||||:.||...:.|
  Fly   668 EEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIY 732

Human   691 VDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRN--KD---EKYNHIDESEM 750
            .:||.:|.|:......|..|.||||:..:.|...:....|.....||  ||   || :...:.|:
  Fly   733 EEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRNLTKDTNPEK-DVFTQVEI 796

Human   751 KKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKL- 814
            ..::|.:.|...|:.....||.|.:.:.|..:..::|..|:..|:...:.:|.  |.||..||:
  Fly   797 DTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDREVKYLVN--KIKIWKPKVK 859

Human   815 -----------ERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGE 846
                       |...:|...|.|.||.|.:.....:...|..|
  Fly   860 PAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQE 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	ASKHA_NBD_HSP70_HSPH1	39..383	CDD:466845	114/360 (32%)
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	114/360 (32%)
		PTZ00121	<546..917	CDD:173412	95/390 (24%)
		TAF4	<572..>627	CDD:461598	17/66 (26%)