Protein Alignment CFTR and cftr

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: NP_001038348.1
• Gene: cftr / 559080
• ZFINID: ZDB-GENE-050517-20
• Length: 1485
• Species: Danio rerio
• Alignment Length: 1507
• Identity: 833/1507 - (55%)
• Similarity: 1130/1507 - (74%)
• Gaps: 49/1507 - (3%)

Human     1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS-K 64
            |||||:|.|:.:|:.||.||.||:|||::::|..||:||.||.|:||.|:|:||:|||||:|| |
Zfish     1 MQRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGK 65

Human    65 KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCL 129
            |.|.|:.|:.||:...|:.:|..||:||.||.|||.||||||||:||.::.||:...:|..||.|
Zfish    66 KKPSLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFDPAHEPERANGYFLAFGLGL 130

Human   130 LFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEG 194
            ||..|.|||.||:|||||:|||:|||:||:|||||||||||||||||.||||||:|.||.|||:.
Zfish   131 LFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFDQS 195

Human   195 LALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERL 259
            |.:|||:||:|||..|..||||||:..::||.|..:.:|.:.||.|...|..|:.|:....::||
Zfish   196 LGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKVLLTNKRL 260

Human   260 VITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
            .:|||::||:.|||||.|||.||.:|:|:||.|:|||||...:|||.|||:|||..||:..:|:|
Zfish   261 ALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSSAYFFSAIFVIVAAVVP 325

Human   325 YALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTT 389
            :||.:||.||:||||:|:|:||||.||||.|.::|.|||::..|.||::||.|:|||.:||:|:.
Zfish   326 HALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRLIWKIEEFLSKEEYKLMEYDLSI 390

Human   390 TEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLL 454
            ||:.:::|||.|:||.|||.|:.||.|......|||..|||:|  |...||||||:.|:::|::|
Zfish   391 TELELQDVTASWDEGPGELLERIKQENKANGHHNGDAGLFFTN--LYVAPVLKDISLKLKKGEML 453

Human   455 AVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRS 519
            ||.||.|:||:||||.|:|||.||.|||:||||||:.||.:|||||||::||:||::||||||:|
Zfish   454 AVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISYSSQTAWIMPGTIRDNILFGLTYDEYRYKS 518

Human   520 VIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEK 584
            |:||||||||::...|||...:.|||:.|||||:||::||||||:||||||||:||.:||:.|||
Zfish   519 VVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALARAVYRDADLYLLDAPFTHLDIATEK 583

Human   585 EIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDS 649
            |||:.|:|||||:|||||||:|:||||:|||||:||.|.|:|||||.|||:.:|||||.|:|.::
Zfish   584 EIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESFFYGTFPELQSERPDFSSLLLGLEA 648

Human   650 FDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGE-----FGEKRKNSILNPINSIR 709
            :|..|||||.|||||||||.|::..|.:   :.::.:|:|...     ..|::.:.|:||:...|
Zfish   649 YDNISAERRCSILTETLHRVSVDESAGM---QPERSAFRQVPPTKPMYIDERKASVIVNPLGVAR 710

Human   710 KFSIVQKTPLQMNGIEEDSDEPL-ERRLSLVPDSE-QGEAILPRISVISTGPTLQARRRQSVLNL 772
            |.|.:| .|      ||:....| :|:.||||::| ..|:.:......:.|..:..:||||||..
Zfish   711 KASFIQ-VP------EEEVRRTLPDRKFSLVPENELVDESFMGSDVYHNHGVHMAGQRRQSVLAF 768

Human   773 MTHSVNQGQNIHRKTTASTRKVSLAPQANL-TELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
            ||::..||:..|.: ::..|::|:.||:.| :|||||:||||..| .:::..:.||:::.|..|:
Zfish   769 MTNAQGQGRREHLQ-SSFRRRLSVVPQSELASELDIYTRRLSDST-YDMTGILEEENIEACLTDE 831

Human   837 MESIP---AVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLL----------GNTP 888
            ::.|.   ..|.||||:||::.:|||::|||:.|.|...|:|.|:..::|:          .:.|
Zfish   832 IDEIEETFETTKWNTYVRYVSNNKSLLYVLIFILFIAAIEIAGSVAGIFLITDELWREEHQRSEP 896

Human   889 LQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKML 953
            ...|.::..|...:||:.:|.|||||:.||||..:::|||||||||||.|||.||:||.||.|||
Zfish   897 NMTKHSNASSSGQTYAITVTPTSSYYILYIYVATSESLLAMGFFRGLPFVHTTITISKKLHQKML 961

Human   954 HSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
            |:||.||||.|||:|.|.|:|||:||:|.:||:|||.:|||:||.::|:|.|.||::::||||:|
Zfish   962 HAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGCILVVSIVRPYIFLA 1026

Human  1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALN 1083
            ..|:.:.||::|.|||:|.|||||||:|.|||||:||:.|||||||:|||.||.|||.||||.||
Zfish  1027 ATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLKGLWTIRAFERQAYFEALFHKTLN 1091

Human  1084 LHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
            .|||.|||||||||||..|.:::||.||....:|::.|..:..|.:|||:.|||.|:.|.||.|.
Zfish  1092 THTATWFLYLSTLRWFLFRADILFVFFFTLAAWIAVGTNQDKPGEIGIIICLAMLILGTFQWCVA 1156

Human  1149 SSIDVDSLMRSVSRVFKFIDMPTE-GKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTV 1212
            :||.||.:||||.|||||||:|:| .||.|.    |:..|    ||||...:.|..||..||:.|
Zfish  1157 TSIAVDGMMRSVDRVFKFIDLPSETPKPDKG----KDSDL----IIENVDAQADSSWPHRGQIEV 1213

Human  1213 KDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSI 1277
            ::||.||||.|:|:|:|:|||....||||:|||||||||:|.:|.|:|:.|:|||.||||:|:.:
Zfish  1214 RNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLVYTDGEISIDGVNWNKM 1278

Human  1278 TLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDG 1342
            .||:|||||||:|||||||:|..|.|||||...||:|:|:||:||||::||||||.||||.|..|
Zfish  1279 PLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVIEQFPDKLDFQLEYG 1343

Human  1343 GCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAM 1407
            |.|||:|||||:|||||:||.|:|||||||||||||||.:::::||:|:|:.||::|.||::|.:
Zfish  1344 GYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKKTLRQSFSTCTILLSEHKVEPL 1408

Human  1408 LECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAA----LK 1468
            ||||.||::::.:|:.||||||||||.|..:|||||::|:||||.||||....:.::::    |:
Zfish  1409 LECQSFLMMDKGQVKTYDSIQKLLNETSHLKQAISPAERLKLFPRRNSSMRTPQSKLSSVTQTLQ 1473

Human  1469 EETEEEVQDTRL 1480
            ||.|:.:|||||
Zfish  1474 EEAEDNIQDTRL 1485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	831/1505 (55%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		66/184 (36%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		49/97 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		11/31 (35%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480		1/1 (100%)
cftr	NP_001038348.1	CFTR_protein	1..1485	CDD:273530	831/1505 (55%)
		Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569	653..826		66/184 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1485		12/32 (38%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569	1483..1485		1/1 (100%)