Protein Alignment CFTR and CG31792

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Alignment Length: 1490
• Identity: 401/1490 - (26%)
• Similarity: 719/1490 - (48%)
• Gaps: 205/1490 - (13%)

Human     1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-ASK 64
            :..:|.|::::.|.|.|.:|.|...||.:..|...|:|:......|::|..||...|..|| .:|
  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNK 73

Human    65 KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCL 129
            ||..|:..|.|.|...|:|.|:.|:..||...|||:.|.::|:|:...:.....:|.....|:.|
  Fly    74 KNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVIL 138

Human   130 LFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEG 194
            ...::.:|::|..|.:.|:|:::|:.:.|:||:|.|:|:...|.:||.|.:::|:||:|.:.|..
  Fly   139 GSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTF 203

Human   195 LALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERL 259
            :...|::|:||||..::..|:::.:..:|..|:.|:::....|..||:.:...|.:.|.:..:|:
  Fly   204 IQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRM 268

Human   260 VITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFV---VFLS 321
            .|.:|:|..||.:|.|.||...|||:.:.|..|:...|..||.:..   .:.|:.|..   :|||
  Fly   269 RIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCL---IWSFNRFLTPVSIFLS 330

Human   322 VLPYALIKGIILRKI-FTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEY 385
            ::.:.|:...:..:: |...::..|:|..:|..|...|....::|.:|.::|..|...|....:.
  Fly   331 LVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDE 395

Human   386 NLTTTEVVMENVTAFWEEGFGELFEK-----AKQNNNNRKTSNGDDSLFFSNFSLLGTP-----V 440
            |:.:...         ||...|..||     .......:...|.:|.:..|......|.     .
  Fly   396 NVVSNGA---------EEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYT 451

Human   441 LKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKEN 505
            |..:|.::..|.|:|:.|.||:||:||:..|:|||....|:|:.:|.:|:.||..|:..||:::|
  Fly   452 LSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQN 516

Human   506 IIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYL 570
            |:||...|..||..|::.|.||.|......||..:||:.|.:|||||:|||||||:||:||.:||
  Fly   517 ILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYL 581

Human   571 LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQN 635
            ||.|...:|....:.:||.|:...:.:|..||||.:::.|::||:|:|:..|.....||:
  Fly   582 LDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY----- 641

Human   636 LQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNS 700
                                        |:||:..|:
  Fly   642 ----------------------------ESLHKSGLD---------------------------- 650

Human   701 ILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARR 765
                      |.||...|:..|...||     ..|.|.:.|                      :|
  Fly   651 ----------FGIVLDDPVNDNEAAED-----RSRTSSITD----------------------QR 678

Human   766 RQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLK 830
            |.||.::::|:.:..:::     ...:|::|            .|:.....||.:
  Fly   679 RSSVKSVLSHAESCPEDV-----GEEQKINL------------QRQQLGRNGLGV---------- 716

Human   831 ECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNS 895
              :.|...:.....:::..:.:....:.            ||.:....:..|:..|..:.....:
  Fly   717 --YVDYFRAGGGFLSFSVVMTFFVCSQG------------LASLGDYFLSPWVSRNEKMVAHNYT 767

Human   896 THSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP 960
            |.:::..:.:        :..|||:.:....:.:...|.....:..:..|..||:.|...:.:|.
  Fly   768 TDAKDADFEM--------HAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRAS 824

Human   961 MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVA 1025
            |...|...||.||||||||:..:|::||..|...||..|:..|.|.|:|::.|...:..:...:.
  Fly   825 MYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIV 889

Human  1026 FIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWF 1090
            ...||:::|:||..:|:||:..|||:::|...||.||.|:||||.....|..|....::|::..:
  Fly   890 IYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASY 954

Human  1091 LYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
            :::||.|.|...:::..|:|...:|....:........||:.:|.||.:..|:||.|..|.::::
  Fly   955 MFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELEN 1019

Human  1156 LMRSVSRVFKFIDMPTEG--KPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAK 1218
            .|.||.|:.::.::..||  :.|...||:::                   ||..|::...:|:.:
  Fly  1020 TMISVERMIEYEEIEPEGPLEATADKKPHES-------------------WPEQGKIEFVELSLR 1065

Human  1219 YTE--GGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQ 1281
            |..  ...::|:::||.|.|.::||::||||:|||:|::|..||...:|.::||....:.:.|..
  Fly  1066 YEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHD 1130

Human  1282 WRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVL 1346
            .|....:|||:..:||||.|.||||::::||..:|...:||.|:.|:......|:..:.:||...
  Fly  1131 LRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNF 1195

Human  1347 SHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQ 1411
            |.|.:||:||||::|...:||::||.:|::||.|..:|:.|::..|.:|||:...||:..:::..
  Fly  1196 SVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSD 1260

Human  1412 QFLVIEENKVRQYDSIQKLL--NERSLFRQAISPS-----DRVKLFPHRNSSKCKSKPQI 1464
            :.||::..:|.::.:..:||  ::.:.|:..:..:     |.:.....|...| ..||.:
  Fly  1261 RVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEK-SEKPSL 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	401/1490 (27%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		24/176 (14%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		18/86 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		4/13 (31%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	398/1481 (27%)