DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CFTR and CG31793

DIOPT Version :10

Sequence 1:NP_000483.3 Gene:CFTR / 1080 HGNCID:1884 Length:1480 Species:Homo sapiens
Sequence 2:NP_609930.4 Gene:CG31793 / 326161 FlyBaseID:FBgn0051793 Length:1307 Species:Drosophila melanogaster


Alignment Length:1487 Identity:411/1487 - (27%)
Similarity:719/1487 - (48%) Gaps:239/1487 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELA------ 62
            :|.|.|.::|.|.|.:..|||.||.:|.|:.:|:|:..:...|.:|.::..:.|:.|:|      
  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKG 73

Human    63 -SKKNPKLINALRRCFFWRFMFYGIFLYLGEV-TKAVQPLLLGRIIASY-DPDNKEERSIAIYLG 124
             |.:.|.::..:.|.|.||.:..||.:...|: |:|..||||..:|:.: :..|....:..|| .
  Fly    74 DSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIY-A 137

Human   125 IGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLN 189
            :.|....:...||.||.:.|:.|:.|:||:|:.|.||:|.|:||...|...:.||:|:||||:||
  Fly   138 VLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLN 202

Human   190 KFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGK 254
            :||..|...||:|:.||::.:....::|.:..::|.|:..|::....|..|.|:..|.|.|.|.:
  Fly   203 RFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALR 267

Human   255 ISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVF 319
            ..:|:.:.:|:|..||.:|.|.||....|:|..:|::|:...|:...:|....|.....|...:|
  Fly   268 TDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIF 332

Human   320 LSVLPYALIKG-IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTL 383
            :|:|.:.|..| :...:.|...:|..:||..|::.||..:..:.:.|.::.:|.:|:.::|...:
  Fly   333 VSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVI 397

Human   384 EYNLTTTE-------VVMENVTAFWEEGFGE----LFE----KAKQNNNNRKTSNGDDSLFFSNF 433
            :.:....|       ::.|.....:..|.|:    |.|    :|:........            
  Fly   398 DMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDL------------ 450

Human   434 SLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIM 498
                  ||.::|..:.||||:||.|..|:||:||:..|:|||.|..|.::.||:.|:.||..|:.
  Fly   451 ------VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLF 509

Human   499 PGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVY 563
            ..::::||:||:..|:.|||:|:|.|.||.|: :....|..::||.|.:|||||||||.||||||
  Fly   510 NASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTIVGERGASLSGGQRARICLARAVY 573

Human   564 KDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYG 628
            :.||:||||.|...:|....:.:|:.|:...:..:..||||.:::.|:.||.|:|:.:|.....|
  Fly   574 RRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACG 638

Human   629 TFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEF 693
            |:.|:.....||:                  .:|.|:... |..||..:    |.....:|:...
  Fly   639 TYEEMLKSGQDFA------------------QLLVESTQN-SGGGDEII----TSPNLSRQSSAL 680

Human   694 GEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTG 758
            ..|..|...:.:.|:               :|::..:|                     |.:|: 
  Fly   681 STKSSNGSSSSLESM---------------VEKEKPKP---------------------SAVSS- 708

Human   759 PTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEE 823
                           ..|.:.||                     ..|.:|.:......|:     
  Fly   709 ---------------QESRSGGQ---------------------IGLSMYKKYFGAGCGV----- 732

Human   824 INEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTP 888
                                               |:||::               ::..:|...
  Fly   733 -----------------------------------LVFVVL---------------IMLCIGTQI 747

Human   889 LQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKML 953
            |...|:..    .||.|..|::||....|.:..:...|:.....|.|...:..:..|..||:.|.
  Fly   748 LASGGDYF----LSYWVKNTASSSTLDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMF 808

Human   954 HSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
            ..:.:..:...:|..:|.|||||:.|:..:|:::|..:.|.||:.|.:.|.|.|:.|..|:..:.
  Fly   809 QGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLIN 873

Human  1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALN 1083
            |..:::||...|.::|:||:.:|:||:..|||:::|...:|.||.|:||.|.|......:....:
  Fly   874 TFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQD 938

Human  1084 LHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTG-EGEGRVGIILTLAMNIMSTLQWAV 1147
            ||::.::.::||.|.|...:::..|.:.|:|...:..... ...|::|:.:|.|:.:...:||.:
  Fly   939 LHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003

Human  1148 NSSIDVDSLMRSVSRVFKFIDM--------PTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIW 1204
            ..|.::::.|.||.||.::.|:        |.|.:|.||                         |
  Fly  1004 RQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKS-------------------------W 1043

Human  1205 PSGGQMTVKDLTAKYTEGGNA--ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEI 1267
            |..|::..|||:.:|....|:  :|:.:||:|.|.::||::||||:|||:|::|..||...:|.|
  Fly  1044 PKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLSYNDGAI 1108

Human  1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
            .||.:..:.|.|...|....:|||:..:||||.|.||||:||:.|.::||..::|.|:..|.:.|
  Fly  1109 LIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELP 1173

Human  1333 GKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTV 1397
            ..|..::.:||...|.|.:||:||||::|.:.:||::||.:|::||.|..:|:.|::..|.||||
  Fly  1174 SGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTV 1238

Human  1398 ILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL--NERSLFRQAISPSDRVKLFPH 1452
            :...||:..:::..:.||::...|.::.|..:||  ::..:|...:..:.:.. |.|
  Fly  1239 LTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKAS-FDH 1294

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CFTRNP_000483.3 CFTR_protein 1..1480 CDD:273530 411/1487 (28%)
Disordered R region. /evidence=ECO:0000269|PubMed:10792060 654..831 20/176 (11%)
Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936 1386..1480 17/69 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1480 1/1 (100%)
PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976 1478..1480
CG31793NP_609930.4 PLN03130 10..1305 CDD:215595 411/1486 (28%)
Blue background indicates that the domain is not in the aligned region.

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