Protein Alignment CFTR and Cftr

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: XP_006236159.2
• Gene: Cftr / 24255
• RGDID: 2332
• Length: 1665
• Species: Rattus norvegicus
• Alignment Length: 1481
• Identity: 1155/1481 - (77%)
• Similarity: 1305/1481 - (88%)
• Gaps: 6/1481 - (0%)

Human     1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKK 65
            ||:|||||||.:||||||||.||||||||..||||||||.||.||||:||||||||||||.||||
  Rat   190 MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDREQASKK 254

Human    66 NPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLL 130
            .|:||:||||||.|||:|||:.||||||||||||:|||||||||||||.||||||||||||||||
  Rat   255 KPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYLGIGLCLL 319

Human   131 FIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGL 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   320 FIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEGL 384

Human   196 ALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLV 260
            |||||:|||||||.|||||:|:|||.|||||||.||||.:|||.||:||:||||:||.||:||||
  Rat   385 ALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERLV 449

Human   261 ITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPY 325
            ||||:|:||.||||||||.||||:||:||:.|||:||::||:|:|.|||||||||||||||||||
  Rat   450 ITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVFLSVLPY 514

Human   326 ALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTT 390
            .:|.||:||||||||||||||||:||||||.|||.||||||.|.|||||||.||||.|||||..|
  Rat   515 TVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVLEYNLMFT 579

Human   391 EVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLA 455
            .:|||||||||||||.||.||.:.||::||||||::.|.||:..|:|.||||:||..|::|::||
  Rat   580 GLVMENVTAFWEEGFQELLEKVQLNNDDRKTSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLA 644

Human   456 VAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSV 520
            :.||||||||||||:|:||||.|||.||||||:||.||.|||||||||||||||||||||||:||
  Rat   645 ITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSV 709

Human   521 IKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKE 585
            :|||||:|||:||||:||.||||||:|||||||||||||||||||||||||||||||||||||::
  Rat   710 VKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQ 774

Human   586 IFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSF 650
            |||||||||||:|||||||||||.|||||||||||||||||||||||||:|:|||||||||.|:|
  Rat   775 IFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTF 839

Human   651 DQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQ 715
            |||:.|||:|||||||.|||:: ||..:|.:. ||||:||||||||||||||:..:|::|.||||
  Rat   840 DQFTEERRSSILTETLRRFSVD-DASTTWNKA-KQSFRQTGEFGEKRKNSILSSFSSVKKISIVQ 902

Human   716 KTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG 780
            ||||   .||.:||:..|||||||||||.|||.|||.::|:.|||...|||||||:|||.:.:..
  Rat   903 KTPL---SIEGESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSV 964

Human   781 QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT 845
            .:..::|.||.||:||||:.:|.|.|||||||||::.|.|:||||||||||||||||..||.|||
  Rat   965 SSSLQRTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTT 1029

Human   846 WNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITST 910
            |||||||.|:|:.|..|||||:::||.||||||.|||||.|.|:....|.|...|.||.|:|||:
  Rat  1030 WNTYLRYFTLHRGLFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVVVITSS 1094

Human   911 SSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNR 975
            |.||:|||||||||||||:..||||||||||||.|||||.|||||:|.|||||.|.|||||||||
  Rat  1095 SFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNR 1159

Human   976 FSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQL 1040
            ||||||||||.||||||||||||.||:|||.||:.||||||:||||.:..||:||||||.|||||
  Rat  1160 FSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAVFILLRAYFLHTSQQL 1224

Human  1041 KQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEM 1105
            ||||||||||||||||||||||||||||.||.||||||||||||||||||:||:|||||||||:|
  Rat  1225 KQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDM 1289

Human  1106 IFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMP 1170
            |||:|||.||||||||||||||..|||||||||||||||||||||||.|||||||||||||||:.
  Rat  1290 IFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQ 1354

Human  1171 TEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSI 1234
            ||.. .||..|...:......::|:|.||||.|.|||||:|.|||||.||.:.||||||||||||
  Rat  1355 TEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGEMVVKDLTVKYVDDGNAILENISFSI 1419

Human  1235 SPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGT 1299
            |||||||||||||||||||||||||:||.:||||||||||:|:|||:||||||||.|||||||||
  Rat  1420 SPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGT 1484

Human  1300 FRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKA 1364
            ||:||||..:|.|:|||||||:|||:||||||||:|:|.|||||.||||||||||||||||||||
  Rat  1485 FRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKA 1549

Human  1365 KILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQK 1429
            ||:|||||||:|||:|||:|||.|:||||.|||:||||||||||:||:|||||:..|.||:|:|.
  Rat  1550 KIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQA 1614

Human  1430 LLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL 1480
            ||:|:|:|::|:|.|:::|||..|:|||.|.:.||.|:|||||||||:|||
  Rat  1615 LLSEKSVFQRALSSSEKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL 1665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	1153/1479 (78%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		109/176 (62%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		60/93 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		18/27 (67%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480		1/1 (100%)
Cftr	XP_006236159.2	None