Protein Alignment ADCY2 and Gyc76C

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 85/279 - (30%)
• Similarity: 130/279 - (46%)
• Gaps: 61/279 - (21%)

Human   835 KNKFKKER---------EEIETME----NLNRV-----------------LLENVLPAHVAEHFL 869
            :|:.||.|         :.:|.||    ||..:                 ||..:||..|||
  Fly   818 RNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAE--- 879

Human   870 ARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSG 934
             :....:.:...|||.|.:.|:.|..|.....||    ..|:.:..||::...||.::   :...
  Fly   880 -KLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAES----TPLQVVNFLNDLYTVFDRII---RGYD 936

Human   935 VEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSF-----ND 994
            |.|::|||..||..:||.......|:          |.:...|..|   |.|:.:|..     ..
  Fly   937 VYKVETIGDAYMVVSGLPIKNGDRHA----------GEIASMALEL---LHAVKQHRIAHRPNET 988

Human   995 FKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL--GYTC 1057
            .|||:|::.|||:|||:|...|:|.::|:|||.||||:|.|...||.::.:..|.|..|  ||..
  Fly   989 LKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYIT 1053

Human  1058 TCRGIINVKGKGDLKTYFV 1076
            ..||::|:|||||:.|:::
  Fly  1054 EKRGLVNMKGKGDVVTWWL 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717
		Guanylate_cyc	281..465	CDD:425528
		Adcy_cons_dom	495..600	CDD:461877
		Guanylate_cyc	878..1077	CDD:425528	69/206 (33%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		3/16 (19%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		1/7 (14%)
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593
		PK_GC-A_B	543..827	CDD:270944	4/8 (50%)
		HNOBA	<833..881	CDD:462234	12/51 (24%)
		CYCc	860..1052	CDD:214485	66/215 (31%)