DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADCY2 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	279	Identity:	85/279 - (30%)
Similarity:	130/279 - (46%)	Gaps:	61/279 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   835 KNKFKKER---------EEIETME----NLNRV-----------------LLENVLPAHVAEHFL 869
            :|:.||.|         :.:|.||    ||..:                 ||..:||..|||
  Fly   818 RNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAE--- 879

Human   870 ARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSG 934
             :....:.:...|||.|.:.|:.|..|.....||    ..|:.:..||::...||.::   :...
  Fly   880 -KLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAES----TPLQVVNFLNDLYTVFDRII---RGYD 936

Human   935 VEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSF-----ND 994
            |.|::|||..||..:||.......|:          |.:...|..|   |.|:.:|..     ..
  Fly   937 VYKVETIGDAYMVVSGLPIKNGDRHA----------GEIASMALEL---LHAVKQHRIAHRPNET 988

Human   995 FKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL--GYTC 1057
            .|||:|::.|||:|||:|...|:|.::|:|||.||||:|.|...||.::.:..|.|..|  ||..
  Fly   989 LKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYIT 1053

Human  1058 TCRGIINVKGKGDLKTYFV 1076
            ..||::|:|||||:.|:::
  Fly  1054 EKRGLVNMKGKGDVVTWWL 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831
		CYCc	236..439	CDD:214485
		Guanylate_cyc	281..465	CDD:278633
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485	70/235 (30%)
		Guanylate_cyc	878..1077	CDD:278633	69/206 (33%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		3/16 (19%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/7 (14%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	4/8 (50%)
		HNOBA	<835..881	CDD:285003	12/49 (24%)
		CYCc	860..1052	CDD:214485	66/215 (31%)
		Guanylate_cyc	887..1074	CDD:278633	69/206 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810