DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADCY2 and ACXB

DIOPT Version :9

Sequence 1:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens
Sequence 2:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster


Alignment Length:1192 Identity:318/1192 - (26%)
Similarity:536/1192 - (44%) Gaps:231/1192 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     4 EAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFAL 68
            |.:..|.||:.:.:|                   .|:.:::......|:|...:....|.:|..:
  Fly    19 ERLWERGYLKAKCKE-------------------LCLEEEYKKYQIRLMISYLTVFFPLFIFVVV 64

Human    69 GLEV------EDH----------VAFLITVPTALAI-FFAIFILVCIESVFKKLLRLFSLVIWIC 116
            |.|:      |..          :..|:.||..|:| ||..|:|      ..:.:.:||.::...
  Fly    65 GCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVL------RHRWIMVFSSILSAY 123

Human   117 LVAMGYLFMCFGGTVSPWDQVSFF-------------LFIIFVVYTMLPF-NMRDAIIASVLTSS 167
            :|.:..:|           |:..|             :|::.::|..||. ::|.   |::|.:|
  Fly   124 IVVLVDIF-----------QILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRG---AALLATS 174

Human   168 SHTIVLSVCLSATPGGKE------HLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNC 226
            ...:.:.:.:.......|      |.:..|..::..::..||.|.:.:.:.:..::.::.|....
  Fly   175 VSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQF 239

Human   227 IKSRIKLEFEKRQQERLLL-SLLPAHIAMEMKAEIIQRLQGPKAG------QMENTNNFHNLYVK 284
            :|..:.|. :.||||.:|| |:||..||..::..|.:|:...:..      ....|.||  :.::
  Fly   240 LKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENF--MAIQ 301

Human   285 RHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPI 349
            .|.:|||||||:|.:|.|.:..:..:||.:|::|:|:||..|...:..|||.||||||||:||..
  Fly   302 IHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGE 366

Human   350 SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLAN 414
            :.|:||:..|.:|:.|...|::||....:||:||:|||||.:|.||||..|.|||:|..||.:||
  Fly   367 ADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIAN 431

Human   415 HMEAGGVPGRVHISSVTLEHLNGA-YKVEEGDGDIR-DPYLKQHLVKTYFVINPKGERRSPQHLF 477
            .:||.|.||.||:|..||..||.| |.|..|....: ||.|::..:.||.               
  Fly   432 RLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYL--------------- 481

Human   478 RPRHTLDGAKMRASVRMTRYLESW--------GAAKPFAHLHHRDSMTTENGKISTTDVPMGQHN 534
                 |..|..|.|||....:.|:        ||::....|  |.::.::..:.....:|:|..|
  Fly   482 -----LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RPTLMSDELREEFKKMPVGGFN 539

Human   535 FQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPA 599
            .::...|..|.    :|::|                   ..:....:.|.:..||..|.......
  Fly   540 IRSPCCRDNSN----DEKVN-------------------HGLGMFCVAFKDSSLEWSYLHKPDFI 581

Human   600 FKYYVTCACLIFFCIFIVQIL-----VLPKTSVLGI---SFGAAFLLLAFILFVCFAGQLLQCSK 656
            .||.|..|..|..|:..:||:     :..:..|:.:   :|..:.|.:::...||:...:...|:
  Fly   582 LKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSR 646

Human   657 KASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSA 721
            |...:...|.|.        |.||..:.:....|.|..|.:.:.|          .:|...:...
  Fly   647 KYGRVSCKLFKI--------WERIQHSFVLRVTIYMSIVASYYLL----------ISTILLNCDK 693

Human   722 SNNQVAILRAQNLF---------FLPYFIYSCILGLISCS-VFLRVNYELKMLIMMVALVGYNTI 776
            :..::.::.:: |:         |.|:.....|..::..| .|.|:.:.|||||...|.|.|..|
  Fly   694 NQYELDVINSK-LYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVI 757

Human   777 LLHTHAHVLGDYSQVLFERPGI---WKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKF 838
            :...::.:        ||....   :...:....:.:.:..:|:....||:|:..:::|......
  Fly   758 VFFQYSFI--------FEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDL 814

Human   839 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES 903
            :.:::..:.......:||.|:||:||.|.:| .|:.|.|||:::|..|.||||.:.:|       
  Fly   815 QGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINF------- 871

Human   904 DVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL------SAVPSQEH-- 959
               :..|..||:||:||.:||.||:..| :..|||||.:|.|||||.||      |...|:.|  
  Fly   872 ---QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHAS 933

Human   960 -------------SQEPERQYMHIG-TMVEFAFALVGKLDAINK--------HSFNDFKLRVGIN 1002
                         |:..|..:..:. .|..||..|:..|...||        .:.:..::.:||:
  Fly   934 YSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGIS 998

Human  1003 HGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKG 1067
            .|.::|||:||.:|.||||||.||:||||:|||:...|.||:||:.:|:.....|..||:..|||
  Fly   999 TGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKG 1063

Human  1068 KGDLKTYFVNTEMSRSLSQSNV 1089
            :|::.||||..:.:.....|||
  Fly  1064 RGEIPTYFVGIDDNLKFLPSNV 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 51/264 (19%)
CYCc 236..439 CDD:214485 93/210 (44%)
Guanylate_cyc 281..465 CDD:278633 85/185 (46%)
DUF1053 495..599 CDD:283888 16/111 (14%)
CYCc 848..1056 CDD:214485 88/238 (37%)
Guanylate_cyc 878..1077 CDD:278633 86/229 (38%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 7/16 (44%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/2 (0%)
ACXBNP_620474.2 AC_N <36..276 CDD:292831 51/260 (20%)
CYCc 249..459 CDD:214485 94/211 (45%)
Nucleotidyl_cyc_III 298..484 CDD:299850 86/205 (42%)
CYCc 825..1047 CDD:214485 87/232 (38%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 85/228 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5262
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.830

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