Protein Alignment ADCY2 and ACXE

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1198
• Identity: 322/1198 - (26%)
• Similarity: 539/1198 - (44%)
• Gaps: 259/1198 - (21%)

Human     1 MWQEAMRRRRYLRDRSEEAAGGGD-GLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGS--CLALL 62
            ||:..     ||:.:..|.....: .|.|.|.|  :||.       |..|:|.|.:.|  |..||
  Fly    17 MWEPG-----YLKAKCAELRLESEFRLYRIRLW--KSYL-------LTFFMLHIFVTSVHCALLL 67

Human    63 A-------VFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIW--ICLV 118
            |       ::|.:.|          ::..||.:...:.:..|.|.:.|....:::..|:  :.||
  Fly    68 ATIERRSIIYFDVAL----------SIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLV 122

Human   119 AMGYLFMCFGGTVSPWDQVSFF-LFIIFVVYTMLPFN-MRDAIIASVLTSSSHTIVLSVCLSA-- 179
            ........:......|...:|: .:||:::|..||.: :..|::.::|.|..:.:...:.::.
  Fly   123 FADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGF 187

Human   180 --------TPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFE 236
                    :.||       :..:::.::|.||.|.:::.:.:..::.::.|....||.:|.|...
  Fly   188 AQFASALFSVGG-------MSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNA 245

Human   237 KRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG-----QMENTNNFHNLYVKRHTNVSILYADI 296
            :.|:::||.|:||..|::.::.:|..|:...|.|     .||.|     :.::.|.:|||||||:
  Fly   246 RLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERT-----MAIQIHPDVSILYADV 305

Human   297 VGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKM 361
            |.:|.|.:..:...||.:|::|:|:||..|...:..|||.||||||||:||....|:||.|||.:
  Fly   306 VNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVIL 370

Human   362 GLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVH 426
            ||.|...|.:|||..|:|||||:||||||:..||||..|.|:|:|..|||:||.:|:.||||.||
  Fly   371 GLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVH 435

Human   427 ISSVTLEHLN-GAYKVEEGDGDIRD-PYLKQHLVKTYFVINPKGERRSPQHL--------FRPRH 481
            ||..||.:|: ..:.:|:|..:.|| |.||::.:::|.:       |...|:        ....|
  Fly   436 ISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII-------RQDLHMDDEDSDEFLGDLH 493

Human   482 TLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQK 546
            ::....|.|..|::                  ||                    .|::||.
  Fly   494 SISLCNMGAQPRIS------------------DS--------------------ANQSLRA---- 516

Human   547 KRFEEELNE------------RMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPA 599
             .|.|||.|            :.:..|...|..|:....::: .|.|.|.:.:||:.|.......
  Fly   517 -LFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNL-NICLTFTDPILERAYLKQTDYM 579

Human   600 FKYYV----TCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFIL----------------- 643
            :||.:    :..|.:.:...:...::.....||..|......:||.|.
  Fly   580 YKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPH 644

Human   644 ----FVCFAGQLLQCSKKASP----LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFF 700
                |.||..::......:.|    :.::|:.||              .....:|:|......|.
  Fly   645 HYNGFSCFIFRIHDKILNSLPIRICIYLFLMISS--------------FFVMCLIVMSCQREEFE 695

Human   701 LSDSEETIPPTANTTNTSFS--ASNNQVAILRAQNLFF--LPYFIYSCILGLISCSVFLRVNYEL 761
            ::..||.:.......:..|.  .:.|.::::......|  :|..:.:.:..|.:.:..|.:.::
  Fly   696 MAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQ- 759

Human   762 KMLIMMVALVGYNTILLH---THAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQ 823
                       ::.:..|   |:.:...:|:..|.                :.|.|:.:.|..||
  Fly   760 -----------FDFVFHHSVTTNPYFKSEYAHALL----------------ICITFLIMFVKERQ 797

Human   824 NEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCV 888
            .|:..:::|.|:...:||........:...::|.|:||:|:.:.:| .||...|||.::|..|.|
  Fly   798 IEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYL-NSLAKHELYFENYRMVSV 861

Human   889 MFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL- 951
            |||.:.:|     |.|     |..||:||||||:||.||...| :..|||||.:|.|||||.||
  Fly   862 MFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLD 916

Human   952 ------------SAVPSQEHSQEPERQYMH----------IGTMVEFAFALVGKLDAINK----- 989
                        .::|..|.::|..|:.:.          :..|..:|..::..|...|:
  Fly   917 LNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSI 981

Human   990 ---HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
               .:..|..:.:||:.|.|:||::||.:|.||||||.||:||||:|||:...|.||||||.:||
  Fly   982 AGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQ 1046

Human  1052 TLGYTCTCRGIINVKGKGDLKTYFVNTE 1079
            ..|.||:.||:..|||:|.:.||.|..:
  Fly  1047 QFGITCSYRGMTFVKGRGKIPTYLVGID 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	138/438 (32%)
		Guanylate_cyc	281..465	CDD:425528	90/185 (49%)
		Adcy_cons_dom	495..600	CDD:461877	19/116 (16%)
		Guanylate_cyc	878..1077	CDD:425528	91/230 (40%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		8/16 (50%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		0/2 (0%)
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	130/409 (32%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	84/168 (50%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	91/229 (40%)