DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADCY2 and Gyc89Da

DIOPT Version :9

Sequence 1:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens
Sequence 2:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	91/324 - (28%)
Similarity:	162/324 - (50%)	Gaps:	50/324 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   772 GYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFIT-------LLVLGRQNEYYC- 828
            |..:|||......:.|...::|....:.::|..:..:.|.:..:.       |::.|.|   :|
  Fly   369 GLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQ---HCS 430

Human   829 RLDFLWKNKFKKEREEIETMENLNRV----------LLENVLPAHVAEHFLARSLKNEELYHQSY 883
            :|:.:    |:||.:..:.:|....:          ||.:::|..:||    |...:||...||:
  Fly   431 KLEIM----FEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAE----RMRLSEEQVCQSF 487

Human   884 DCVCVMFASIPDFKEFYTESDVNKEG-LECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMA 947
            :.|.|:|..:   ...|.|...:.:| ::.:..||::.:..|:.:..|   .|.|::|:|..|||
  Fly   488 EEVSVIFLEV---MNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISP---FVYKVETVGMVYMA 546

Human   948 ATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIG 1012
            .:|           .|:...:|.....:.|..::.|..|   |...|..:|||||.|||:|||:|
  Fly   547 VSG-----------APDVNPLHAEHACDLALRVMKKFKA---HDMGDVAIRVGINSGPVVAGVVG 597

Human  1013 AQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 1076
            .:.|:|.::|:|||.||||:|:....|||:::.|...::.:||....||.:.||||||::||::
  Fly   598 QKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGKGDMETYWL 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831
		CYCc	236..439	CDD:214485
		Guanylate_cyc	281..465	CDD:278633
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485	64/218 (29%)
		Guanylate_cyc	878..1077	CDD:278633	66/200 (33%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		3/17 (18%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/2 (50%)
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	22/117 (19%)
		CYCc	457..643	CDD:214485	64/209 (31%)
		Guanylate_cyc	485..662	CDD:278633	66/197 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810