Protein Alignment ADCY2 and Ac78C

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Alignment Length: 1323
• Identity: 405/1323 - (30%)
• Similarity: 638/1323 - (48%)
• Gaps: 305/1323 - (23%)

Human    26 LPRSRDWLYESYYCMSQQHPLIV-----FLLLIVMGSCLALLAVF--FALG-LEVEDHVAFLITV 82
            |.||    |.:|....:|..||:     |:|.||    ||.:.:.  ..|| :|.:|..:.
  Fly   312 LERS----YLTYTHRQRQKSLIIVNVVDFVLKIV----LAFVWIMRRSELGPIESDDGTSM---- 364

Human    83 PTALAIFFAIF-----ILVCIESVFK----KLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQ-- 136
              |.||.:::.     :.:|....::    ..|...::..|:.....|::    |..|...|:
  Fly   365 --ATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFV----GQGVGFADREY 423

Human   137 -VSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPG----GKEHLVWQILANVI 196
             |.:.||:|||.|.|||..::..::...:|:|.|..|::: :....|    ..|.:::||.||.|
  Fly   424 LVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITI-IKLQHGEATINPECVLFQIFANFI 487

Human   197 IFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEII 261
            ::...|:||.|.|:|.:...:..:.:|...::.:.:.|.|.::.::||.|:||..:..::::|:.
  Fly   488 LYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY 552

Human   262 QRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIA 326
                  |.........|:.|||....|||||:|||.|||.|||..|..:||.:||:||.:||:||
  Fly   553 ------KGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIA 611

Human   327 KENECMRIKILGDCYYCVSGLPI----SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVH 387
            ::|.|:|:|:|||||||||....    :.|:||...|:.||.|.:|||.||..|.||:|||:|:|
  Fly   612 EDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIH 676

Human   388 SGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452
            ||:|:|||:|.:||.:||||:||.:|||||:||:|||||||..||:.||.||:||.|:|..||.:
  Fly   677 SGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNH 741

Human   453 LKQHLVKTYFV-----INPKGE--RRSPQHLFRPRHTL--------------------------- 483
            ||...||||.:     :.||..  .||..||.....|.
  Fly   742 LKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTA 806

Human   484 ---DGAKMRASVRMTRYLESWG--AAKPFAHLHHR-------------------DSMTTENG--- 521
               |||.:..  |...|..:..  |.:|...|..:                   ||....||
  Fly   807 TGNDGASIDG--RSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGV 869

Human   522 -----------------------------------------------------------KISTTD 527
                                                                       ..||||
  Fly   870 MGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTD 934

Human   528 ----VPM--------GQHNFQNRTLRTKSQKK----RFEEELNERMIQAIDGINAQKQWLKSEDI 576
                :|.        |.:...:..:.||...:    ..:||::|.:.|.|. ||:.|: ::.|.:
  Fly   935 WIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQ-INSNKE-IRREYL 997

Human   577 QRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTS--VLGISFGAAFLLL 639
            ...:|.|.:|..|:::.......|:..:.|..:|:..:.:.|::::|:.:  ::.:|.|...|..
  Fly   998 NPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTF 1062

Human   640 AFILFVC--FAGQLLQCSKKASPLL-----------------MWLLKSSGIIA------------ 673
            ..:|.:.  |.| |.:|.|..|..|                 |.:|.:.|::.
  Fly  1063 CCVLVMAEEFPG-LPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADE 1126

Human   674 -NR------PWPRISLT--IITTAIILMMAVFNMFFLS-----------------DSEETI---- 708
             :|      |:..||:|  .....:.|...:.:...:|                 .|:|.:
  Fly  1127 HSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTL 1191

Human   709 --------PP--------TANTTNTSFSASN---NQVAILRAQN-----LFFLPYFIYSCILGLI 749
                    ||        |..|...|.|.||   :..:::::.:     .....|.:::.:|.|:
  Fly  1192 NALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLV 1256

Human   750 SCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGD-YSQVLFERPGIWKDLKTMGSVSLSIF 813
            |.:..|::.|.:|.|:.:..:..|.|:::.....  || :|.|...|.|:     .:| |.:.|.
  Fly  1257 SLATALKLYYLVKALMALAMVAFYTTLIMMKFGS--GDSFSLVELSRLGM-----PLG-VQMLIL 1313

Human   814 FITLLVL----GRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLK 874
            .|:.||:    .|..|...||||:||.:.::|...:::...||..|::|:||.|||.::|:.. .
  Fly  1314 LISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-H 1377

Human   875 NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIK 939
            .:|||.:.::...|||||||:|::||:| |:: .|..|:|:|||||.|||:||.:|:|:.|||||
  Fly  1378 TDELYSKMHNLCGVMFASIPNFQDFYSE-DID-NGKACIRILNEIICDFDELLEEPRFASVEKIK 1440

Human   940 TIGSTYMAATGLSAVPSQEHSQ-EPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINH 1003
            |:|:|||||.||    :.||.: ..|.....:..:||||||:..||:.||..:||:|:|||||..
  Fly  1441 TVGATYMAAAGL----NHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICS 1501

Human  1004 GPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGK 1068
            ||:::|||||:||.||||||||||||||||||...::||.|.|:.:|.:.||||..||.|.||||
  Fly  1502 GPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGK 1566

Human  1069 GDLKTYFVNTEMSRSLSQSNVAS 1091
            |.:.|::|:   .:.:|:|.:.|
  Fly  1567 GMMTTFYVH---PKGISESQLIS 1586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	164/440 (37%)
		Guanylate_cyc	281..465	CDD:425528	108/192 (56%)
		Adcy_cons_dom	495..600	CDD:461877	29/203 (14%)
		Guanylate_cyc	878..1077	CDD:425528	109/199 (55%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		8/16 (50%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		0/2 (0%)
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	63/257 (25%)
		Guanylate_cyc	566..753	CDD:425528	108/186 (58%)
		Adcy_cons_dom	929..1021	CDD:461877	21/93 (23%)
		Guanylate_cyc	1381..1576	CDD:425528	110/203 (54%)