Protein Alignment ADCY2 and CG43373

DIOPT Version :9

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Alignment Length: 1048
• Identity: 405/1048 - (38%)
• Similarity: 598/1048 - (57%)
• Gaps: 129/1048 - (12%)

Human    70 LEVEDHVAFLITVPTALAIFFAIFILVCIES------VFKKLLRLFSLVIWICL-VAMGYLFM-- 125
            ::|::.|...:.|.....|.:|  .|:||.|      :|..|:....|..::.: ||:.|...
  Fly   518 MQVDESVLVFLIVMLICGIVYA--FLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPS 580

Human   126 -CFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCL---SATPGGKEH 186
             .|.|:       :..:.:|::.|||||..:|:|:|..:|.|..|   |..||   :......|.
  Fly   581 KSFNGS-------ACCIVLIYMTYTMLPLRLREALIGGILLSVVH---LYTCLRLNAMQDEAVEM 635

Human   187 LVW-QILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPA 250
            :.| ::|..::..:..||.|.|.....|.|.::.:.:|..||::|::.:.|.:||||||||:||.
  Fly   636 IHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPR 700

Human   251 HIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHML 315
            |:|||||.:|        |||..:| .||.:|::||.|||||:|||.|||.|:..|:..|||.:|
  Fly   701 HVAMEMKDDI--------AGQPRDT-QFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLL 756

Human   316 NELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDI 380
            ||||.:||::|.|:.|:|||:||||||||||||...|:||...|:|||||.:||..||:...|::
  Fly   757 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNV 821

Human   381 NMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGD 445
            |||||:|:|.|.|||:||.|||:||||:|||||||||:||:||||||:..||:.|:|.|:||.|.
  Fly   822 NMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGK 886

Human   446 GDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHL 510
            |:.|:.|||.|.::||.::        |..::||                             |.
  Fly   887 GNERNSYLKDHQIETYLIV--------PGDIYRP-----------------------------HK 914

Human   511 HHRDSMTTENGKISTTDVPMGQHNFQNRTLR-----TKSQKKRFEEELNERMIQAIDGINAQKQW 570
            ..|:.:.. ||.||.....||....|..|.:     :....|..|:|:||.:::|||..:...
  Fly   915 KSRNRLQV-NGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDH-- 976

Human   571 LKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSV-LGISFGA 634
            |::|..|.:.|.|.:.|||::|.:........|..|:.|:.....|::::|...:.: |.:|.|
  Fly   977 LRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTG- 1040

Human   635 AFLLLAFILFVCFAGQLLQCSK----KASPLLMWLLKSSGIIANRPWPRIS--LTIITTAIILMM 693
            |.|||.|::|      |:.|.|    ..|.:..:.|:   |.:||   |||  ....:.|:|::.
  Fly  1041 ALLLLGFLVF------LVACHKINFQLPSDIKRFSLR---IHSNR---RISQLFAFASVALIVLT 1093

Human   694 AVFNMF--------------FLSDSEETIPPTANTTNTS-FSASNNQVAILRAQNLFFLPYFIYS 743
            .:..||              |..|...:|.......||. :.|.........|.|.|.|     .
  Fly  1094 TLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLL-----L 1153

Human   744 CILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSV 808
            .:|.::||:.:..:...||:|::::|...|.....:.::. ..:.||.|.....:.:.:  :.|:
  Fly  1154 TLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSR-SREMSQELANEEALLRYI--IDSI 1215

Human   809 SLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSL 873
            .|..|.:.|:....|.|...||||:||.:..:|:|::|.::..||.||||:||.|||||||:|..
  Fly  1216 FLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREK 1280

Human   874 KNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKI 938
            ..::|||:..|.||::|||||:|.|||.|.:.|.||:||||||||||||||:|||:.:|..:|||
  Fly  1281 HLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKI 1345

Human   939 KTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINH 1003
            |:.|:|||||:||:|......:      :.|:..|.::|..|..|::.:|.||||:|::|:|||.
  Fly  1346 KSTGATYMAASGLTANTCDRVN------FSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINI 1404

Human  1004 GPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGK 1068
            |||:||||||.|||||||||.|||||||||||::|.||||:|...:|:..|:..||||.::||||
  Fly  1405 GPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGK 1469

Human  1069 GDLKTYFV 1076
            |.:.|||:
  Fly  1470 GSMITYFL 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	62/203 (31%)
		CYCc	236..439	CDD:214485	123/202 (61%)
		Guanylate_cyc	281..465	CDD:278633	111/183 (61%)
		DUF1053	495..599	CDD:283888	27/108 (25%)
		CYCc	848..1056	CDD:214485	118/207 (57%)
		Guanylate_cyc	878..1077	CDD:278633	114/199 (57%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		13/16 (81%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		2/2 (100%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	66/217 (30%)
		CYCc	686..881	CDD:214485	123/203 (61%)
		Guanylate_cyc	722..895	CDD:278633	106/172 (62%)
		DUF1053	<949..1005	CDD:283888	17/57 (30%)
		CYCc	1259..1455	CDD:214485	117/201 (58%)
		Guanylate_cyc	1285..1479	CDD:278633	114/199 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810