Protein Alignment ADCY2 and ACXD

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 1189
• Identity: 328/1189 - (27%)
• Similarity: 526/1189 - (44%)
• Gaps: 281/1189 - (23%)

Human    62 LAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICL--------- 117
            |.:|..:.:.| .|...|:|.|....::..:...:|           ..||||:.|
  Fly    67 LFIFIHVAVTV-IHTLLLLTTPEIKYVYVDMVAYMC-----------SGLVIWVVLGVNFRSELV 119

Human   118 -------VAMGYLFMC----------------FGGTVSP-WDQVSFFLFIIF--VVYTMLPFNMR 156
                   .|..:|.:|                ....::| :|..:.:...:|  |.|.:.||
  Fly   120 SKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPF--- 181

Human   157 DAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQ 221
              ::.|.:| ..:.|..|..::|....:.|   .||...|...|.||.|.:.:.:.::||:.|:.
  Fly   182 --VLGSAVT-FCYIINYSFVITAKDDNQMH---SILNEAIYLSCVNLLGIFFRLMRDIALRTTFL 240

Human   222 DTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTN---------- 276
            |....::..:.|.:.:.|:..||||:|||.||..::.::..|::..|....:.:.
  Fly   241 DRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQ 305

Human   277 --------NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMR 333
                    :...|:::.|.:|::||||:|.:|.|.:.....:||..|::||.:||..::|...:|
  Fly   306 TLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLR 370

Human   334 IKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGL 398
            ||.||||||||:||.....:|||.||.:||.|.:.|:.||:...::|:||:|||||:||.||||.
  Fly   371 IKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGA 435

Human   399 QKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIR-DPYLKQHLVKTYF 462
            .|||:|:||.||.:||.:||.|..||||:|..||..|:|.|..|:|....| ||.|::|.::|:.
  Fly   436 AKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFL 500

Human   463 VINPKGERRSPQHLFRPR-------------------HTLDGAKMRASVRMTRYLESWGAAKPFA 508
            :.:.:.....|:...|.|                   |..:..:.:|.:.|.|.|
  Fly   501 IKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCREL---------- 555

Human   509 HLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGI----NAQKQ 569
                 |.|..  |:|..|.|      |:..|..|:.:   .|||...|.|.:....    |.:.|
  Fly   556 -----DKMPI--GRIQLTKV------FRRSTRLTQDE---IEEETFRRNISSCCLFFRIRNWEFQ 604

Human   570 WLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGA 634
            ::|..|:.                      .||.:..|.:|:..:..:|:|............|.
  Fly   605 YIKEPDVM----------------------LKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGT 647

Human   635 AFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTA------IILMM 693
            ..:||..:|.|.:..:|            |::..|....:.|..|:|..:...:      :::.:
  Fly   648 TIILLTMLLIVSWYKKL------------WIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRV 700

Human   694 AVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCS-VFLRV 757
            .::.:...|.....|......::....|..:.....|.|  .|.|:.:.:|:..:|..| :|.|:
  Fly   701 VMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQ--CFHPWILTNCMTLVIGMSFLFTRI 763

Human   758 NYELKMLIMMVALVGYNTILL-----------HTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLS 811
            .:.:|.....:.::||..:::           .|:.:....||.:|            :..::..
  Fly   764 PFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKYSHIL------------LMIITFG 816

Human   812 IFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNE 876
            ||.:    :.||.|:..::|:.||.:..|::|:.....:..:|||.|:||.|||:.:|:..|:|
  Fly   817 IFHL----MERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQN- 876

Human   877 ELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFS-GVEKIKT 940
            |||::.||.|.||||||.:|       |.:|.|   ||:|||||.||||:|:|...| .|||||.
  Fly   877 ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKV 931

Human   941 IGSTYMAATGL------------------SAVPSQEHSQ-------------------------- 961
            ...|||||.||                  |.:|:...|:
  Fly   932 ANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALD 996

Human   962 -EPER-QY-------------MHIGT--------MVEFAFALVGKLDAINKHSF-------NDF- 995
             :.|| ||             .|.|:        |.|||..|:..:...|..:.       .|:
  Fly   997 LDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYG 1061

Human   996 KLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCR 1060
            .||:||:||..:|||:|..||.||||||.||:|||||||||..:|||||.|:|.|:.....|..|
  Fly  1062 MLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYR 1126

Human  1061 GIINVKGKGDLKTYFVNTE 1079
            |:..|||:|::.||.:..:
  Fly  1127 GMTFVKGRGNIPTYIIGID 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	140/461 (30%)
		Guanylate_cyc	281..465	CDD:425528	87/184 (47%)
		Adcy_cons_dom	495..600	CDD:461877	20/108 (19%)
		Guanylate_cyc	878..1077	CDD:425528	103/274 (38%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		9/16 (56%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		0/9 (0%)
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	52/237 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	86/181 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	103/273 (38%)