DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADCY2 and CG3216

DIOPT Version :9

Sequence 1:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens
Sequence 2:NP_726013.2 Gene:CG3216 / 37376 FlyBaseID:FBgn0034568 Length:1161 Species:Drosophila melanogaster


Alignment Length:329 Identity:96/329 - (29%)
Similarity:159/329 - (48%) Gaps:62/329 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   154 NMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQ 218
            |..:....|.:.|:..||:...|        |:|:..:|         |....|..:|..|..::
  Fly   865 NQEERPTFSTIRSNIRTIMKGFC--------ENLMDDLL---------NRMEQYANNLESLVEEK 912

Human   219 TYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYV 283
            |.|           |..||::.|.||..:||..:|.::           .||.:.....|     
  Fly   913 TRQ-----------LSLEKQRTEELLYQILPRPVAQQL-----------MAGDLVEPEEF----- 950

Human   284 KRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP 348
               ::|:|.::||||||.|.:..||.::|:.||:|:..||:|....:..:::.:||.|..|||||
  Fly   951 ---SSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLP 1012

Human   349 ISLPN---HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSH 408
              .||   ||:....|.||:..|:.  .:|......|.:|:|:|||:|..||:|.:...|.::..
  Fly  1013 --EPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGD 1075

Human   409 DVTLANHMEAGGVPGRVHISSVTLEHLN--GAYKVEE-GDGDIRDPYLKQHLVKTYFV-INPKGE 469
            .|..|:.||:.|.||::|:||.|...|:  |.:::|: ||.:::.    :..|.||:: ...:||
  Fly  1076 TVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKG----KGTVTTYWLNSTSEGE 1136

Human   470 RRSP 473
            .|.|
  Fly  1137 ARPP 1140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 24/105 (23%)
CYCc 236..439 CDD:214485 70/209 (33%)
Guanylate_cyc 281..465 CDD:278633 65/192 (34%)
DUF1053 495..599 CDD:283888
CYCc 848..1056 CDD:214485
Guanylate_cyc 878..1077 CDD:278633
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993
CG3216NP_726013.2 PBP1_NPR_like 90..496 CDD:107368
ANF_receptor 107..479 CDD:279440
PKc_like 616..885 CDD:304357 5/19 (26%)
TyrKc 627..877 CDD:197581 2/11 (18%)
HNOBA <882..939 CDD:285003 20/84 (24%)
CYCc 918..1109 CDD:214485 70/211 (33%)
Guanylate_cyc 945..1131 CDD:278633 66/199 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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