DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADCY2 and Ac3

DIOPT Version :9

Sequence 1:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens
Sequence 2:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster


Alignment Length:1201 Identity:389/1201 - (32%)
Similarity:600/1201 - (49%) Gaps:232/1201 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     3 QEAMRRRRYLRDRSEEAAGG----GDG---LPRS-RDWLYESYYCMSQQHPLIVFLLLIVMG--- 56
            |...|||:    ...:.|||    |.|   ||:. .:.||.:|....::..|..|:....:.   
  Fly    23 QTTSRRRQ----NDSDVAGGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIW 83

Human    57 ---------------SCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLL 106
                           :|..|||.   |.|....|:......| ||..|..|.:::...:::  ||
  Fly    84 TIGIPWDQSAPTRVINCCMLLAY---LALTALLHIGRRSDKP-ALRRFHQILLIIVPRALW--LL 142

Human   107 RLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTI 171
            .:....:::.|..          :.||.|.:.:.:.:.|:||..||..:      ..|..|...|
  Fly   143 SILHFTVYVILQP----------SFSPRDLLGWAILLNFLVYVTLPLQL------IFLGLSIGCI 191

Human   172 VLSVCLSATPGGKEHLVW------QILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSR 230
            ...:||| .|.|..|  |      |:.||.::.....|.|..:..:.|...::.:.:....::.:
  Fly   192 TYFICLS-LPVGYSH--WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVK 253

Human   231 IKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYAD 295
            :.:|.:..:|||||||:||.|:|::|:.::     |..:.:.     |..:|:.||.||||||||
  Fly   254 MVIEEQSAEQERLLLSVLPKHVAIKMREDL-----GSSSSEA-----FKKIYMSRHENVSILYAD 308

Human   296 IVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK 360
            |||||.::|..|..:||.||||||.:||::|::.:.:|||||||||||:||.|...|:||..||.
  Fly   309 IVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVH 373

Human   361 MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRV 425
            |||.|.:|||.|:......::||||:|:|.||.|::|.::||:||:|.||.|||.||:.|..|||
  Fly   374 MGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRV 438

Human   426 HISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRA 490
            |||..||..|||.::||...|:.|:..|:...:||||:                           
  Fly   439 HISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI--------------------------- 476

Human   491 SVRMTRYLESWGA--AKPFAHLHHRDSMTTENGKISTTDVP---------------MGQHNFQN- 537
                |:.::::.:  ||.........:....||  ||||:.               :.|::..| 
  Fly   477 ----TKVVKAFASPCAKKINETQAEIAHPNPNG--STTDIVSDEDDNDATLDDEELLAQNSVSNG 535

Human   538 ------------RTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQR---ISLLFYNKV 587
                        ..::.::.|:|.::||..|     ||         .|::.:   |.|.|.|..
  Fly   536 HQIGIAVTADEEEQVKLENFKQRLKDELVTR-----DG---------HENLTKDTNIFLRFKNPQ 586

Human   588 LEKEYRA-----TALPAFKYYVTCACLIFFCIFIV-QILVLPKTSVLGISFGAAFLLLAFILFV- 645
            ||:.|..     ::||..      |.|:..||.:: ..||||::::..|:..|..:.:|.::.: 
  Fly   587 LEQLYAVYREPYSSLPLL------AALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVIS 645

Human   646 ---CFAGQL----LQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSD 703
               .|:|.|    :..||:.:. :.::.:.:.||       |:|||..:.:|      :|||...
  Fly   646 LAESFSGMLPKFFVDVSKRFND-ITFVRELAAII-------IALTIGFSNVI------DMFFFVT 696

Human   704 ---SEETIPPTANTTNTSFSASNNQV--AILRAQNLFFLP--------------------YFIYS 743
               :|..:..:......|..:..|.|  .::.|::|  ||                    |....
  Fly   697 FVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHL--LPASFVEQMRDAVPTERVLYPSYLSNF 759

Human   744 CILGLISCSVFLRVNYELKMLIMM--VALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMG 806
            .:|.||:.:|..::.:..|:|:::  .||..|..|.:....:.|.|.    ||...|   :.|..
  Fly   760 GVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDD----FEHQPI---ISTRY 817

Human   807 SVS--LSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFL 869
            :.|  |.:..:.|..|.|..::..|:.|.||.:..:::|....|...|..|:.||||.||||||:
  Fly   818 AASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFM 882

Human   870 ARSLK-NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFS 933
            ..:.: :::||.|||..|.|:|||:|:|.:||:|..||.:||||||.|||:|:|||.||..|:|.
  Fly   883 KNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQ 947

Human   934 GVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLR 998
            .:.||||||||||||:|::...:..:......::.|:..:||||..|...|.:||:.|||.|.|:
  Fly   948 DIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLK 1012

Human   999 VGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGII 1063
            :||||||:.||||||:||.||||||||||||||:|||....|||||||..:|:..|||...||::
  Fly  1013 MGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLV 1077

Human  1064 NVKGKGDLKTYFVNTEMSRSLSQSN---VAS 1091
            .|||||.|.|:::     :..|||:   |||
  Fly  1078 AVKGKGQLMTFYL-----QGKSQSSAEPVAS 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 57/250 (23%)
CYCc 236..439 CDD:214485 104/202 (51%)
Guanylate_cyc 281..465 CDD:278633 99/183 (54%)
DUF1053 495..599 CDD:283888 27/141 (19%)
CYCc 848..1056 CDD:214485 114/208 (55%)
Guanylate_cyc 878..1077 CDD:278633 112/198 (57%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 12/16 (75%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 1/2 (50%)
Ac3NP_610116.2 AC_N <127..285 CDD:292831 42/183 (23%)
CYCc 256..453 CDD:214485 105/206 (51%)
Guanylate_cyc 294..476 CDD:278633 98/181 (54%)
CYCc 860..1071 CDD:214485 115/210 (55%)
Guanylate_cyc 892..1092 CDD:278633 112/204 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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