DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADCY2 and Phlpp

DIOPT Version :9

Sequence 1:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens
Sequence 2:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster

Alignment Length:	198	Identity:	39/198 - (19%)
Similarity:	68/198 - (34%)	Gaps:	76/198 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   895 DFKEFYTESDVNKEGLEC----LRLLNEIIADFD-DLLSKPKFSGVEKIKTIGSTYMAATGL--- 951
            |..|..:||.:::|..:|    |....:::.|.: :.:||    ...|.:|:.:..||||.|
  Fly   752 DETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISK----SFTKQRTVPNAIMAATVLPER 812

Human   952 ----------------------------SAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAIN 988
                                        ::||...:.|..:....|.|:.:.|..|
  Fly   813 NDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQA--------- 868

Human   989 KHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDST--GVLDKIQ---------V 1042
             ||:       |.|        :...||:....|.||..::..:|.  |.|.::.         |
  Fly   869 -HSY-------GYN--------LFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAV 917

Human  1043 TEE 1045
            |:|
  Fly   918 TQE 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831
		CYCc	236..439	CDD:214485
		Guanylate_cyc	281..465	CDD:278633
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485	39/198 (20%)
		Guanylate_cyc	878..1077	CDD:278633	39/198 (20%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		3/20 (15%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		2/2 (100%)
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900