DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADCY2 and Ac13E

DIOPT Version :9

Sequence 1:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens
Sequence 2:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster


Alignment Length:1606 Identity:354/1606 - (22%)
Similarity:571/1606 - (35%) Gaps:637/1606 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    29 SRDWLYESY--YCMSQQHPLIVF----------LLLIVMGSCLALLAVFFALGLEVEDHVAFLIT 81
            ::.||...:  ..:.:|:...||          |..|::  |..:..::|.:....||   |...
  Fly    66 AKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL--CSLMWCLYFVVDGGSED---FWRP 125

Human    82 VPTALAIFFAIFIL-VCIE--SVFKKLLRLFSLVIWICLVAMGYLFMCF-GGTVSPWDQVSFFLF 142
            :.::.::...:.|: :|..  .::::...:.|.|..:.|......|:.: |...||....:..|.
  Fly   126 ISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAFSPLGHFAICLE 190

Human   143 IIFVVYTMLPFNM----RDAIIASV-LTSSSHTIVLSVCLSATPGGKEH---------------- 186
            |:.::||.||..:    ..||..|: ....||.::  .| ||..||..|                
  Fly   191 IVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVI--GC-SAIHGGPMHGGGGAAGGSGMEANGD 252

Human   187 -----LVWQILANVIIFICGNLAGAYHKHLMELA-LQQTYQDTCNCIKSRIKLEFEKRQQERLLL 245
                 |:.:|:|::.:.:.|     .|..:|.|. ::.|:......:..|.:||.||:.:|:::.
  Fly   253 PSNRILILRIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIH 312

Human   246 SLLPAHIAMEMKAEIIQRLQGPK---AGQM---------ENTNNFHNLYVKRH----TNVSILYA 294
            |::|..:     |:::....||.   ||.:         ..:|:..:|:...|    .|||||:|
  Fly   313 SVMPPKV-----ADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFA 372

Human   295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCV 359
            |||||||::|..:..:||.:||:||.:||.:...:.|.:|..||||||||||.|....:||..||
  Fly   373 DIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCV 437

Human   360 KMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424
            :|||.|.:|::.........:.||||||:|.||||::|.::.::||||:||:|||.||:.|.|.:
  Fly   438 EMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQ 502

Human   425 VHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERR------------------ 471
            ||||..|...|..||.:|||:      .:..|  :||||:   |.||                  
  Fly   503 VHISQETSSFLGDAYYLEEGE------EVFGH--RTYFVV---GRRRDFTRTNSLSPSMPANATG 556

Human   472 ------------------------------------------SPQHLFRPRHTLDGAKMR----- 489
                                                      ||....|||.|....|||     
  Fly   557 SSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQS 621

Human   490 ------------------------------------------------------------ASVRM 494
                                                                        |..|.
  Fly   622 RDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRS 686

Human   495 TRYLESW------------------GAAKPFAH---------------LHHRDSMTTE------- 519
            ...|:.|                  |.:....|               ||..:.:..|       
  Fly   687 KIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMD 751

Human   520 --------------------NGKISTTDVPM---------------------------------- 530
                                |.:..|.|:|.                                  
  Fly   752 NQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCS 816

Human   531 -GQHNF------------QNRT------------------------------------------- 539
             ||::.            |:|:                                           
  Fly   817 PGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTA 881

Human   540 ----------------------------------------------------------------- 539
                                                                             
  Fly   882 PPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSA 946

Human   540 -------LRTKSQKKRFEEE---LNE--------------------------------------- 555
                   :::.|::...:::   ||:                                       
  Fly   947 TSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPP 1011

Human   556 ---------------------------RMIQAI-DGINAQKQWLKSEDIQRISLLFYNKVLEKEY 592
                                       ::|:.: |...:|:.:|....:::.||.|.::.||:::
  Fly  1012 LLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDF 1076

Human   593 RA----------------TALPAFKYYVT--CACLIFFCIFIVQILVLPKTSVLGISFGAAFLLL 639
            |:                .|.|.:..|:.  ....::.||.:...|:...|  :..||     .|
  Fly  1077 RSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNT--VSPSF-----RL 1134

Human   640 AFILFVCFAG----QLLQCSKKASPLLMWLLKSSGIIANR------------------------- 675
            ...||.||.|    .|...:::     |...:|...::||                         
  Fly  1135 WVTLFSCFTGIQVFALFLFTRQ-----MCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPH 1194

Human   676 ----------------PWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNN 724
                            || .|.|.::....:|:  :...|.|.|.|:                  
  Fly  1195 FESCADRIFEAISSWYPW-HICLAVLMAMPVLL--IIANFLLLDLEQ------------------ 1238

Human   725 QVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVA---LVGYNTILLHTHAHVLG 786
                |.|.. :...:.|:.||:..  |: |.::|..::.::..:|   .:|.....|..::|...
  Fly  1239 ----LEAFE-YHYGFLIFVCIVHF--CN-FTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRS 1295

Human   787 DYSQVLFERPGIWKDLKTMGSVSLSIFFITLLV------LGRQNEYYCRLDFLWKNKFKKEREEI 845
            |..|.. |.....:::|......:.|:...||:      |.|:.|...||.|.......:::..:
  Fly  1296 DQQQDQ-EASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRV 1359

Human   846 ETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL 910
            :.|:|...:||.|::|.|||||     |||...|.:::..:.::||||.:|.|.|.||.:.  |.
  Fly  1360 QNMKNQADMLLHNIIPKHVAEH-----LKNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GK 1417

Human   911 ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVE 975
            |.||:|||:|.|||:|||:|:|..||||||||||:|||:||.  ||...:.:.     ||.|::|
  Fly  1418 EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD--PSHRGTGDE-----HIHTLME 1475

Human   976 FAFALVGKLDAINKH--SFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 1038
            |:.|:...:||.||.  .|| ..||:|:|.|.|.|||||..|..|||||:.|||||||||||:.:
  Fly  1476 FSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPN 1539

Human  1039 KIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL 1084
            :|||.:: .|...|..|....||.:.||||..::.:...|.....|
  Fly  1540 RIQVGKD-CLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 54/269 (20%)
CYCc 236..439 CDD:214485 88/218 (40%)
Guanylate_cyc 281..465 CDD:278633 87/187 (47%)
DUF1053 495..599 CDD:283888 29/411 (7%)
CYCc 848..1056 CDD:214485 102/209 (49%)
Guanylate_cyc 878..1077 CDD:278633 95/200 (48%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 8/16 (50%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/4 (0%)
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 89/220 (40%)
Guanylate_cyc 361..535 CDD:278633 85/184 (46%)
CYCc 1362..1556 CDD:214485 102/209 (49%)
Guanylate_cyc 1388..1575 CDD:278633 95/197 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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