Protein Alignment ADCY2 and rut

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Alignment Length: 1196
• Identity: 439/1196 - (36%)
• Similarity: 628/1196 - (52%)
• Gaps: 209/1196 - (17%)

Human    39 CMSQQHPLIV--FLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESV 101
            |:.|::.|.:  |.:|.|:.....|..|..||.|...:...|.......:...||:.:::...||
  Fly    25 CLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSV 89

Human   102 FK--KLLRL-FSLVIW---ICLVAMGYLFMCFGGTVSPWDQ-------VSFFLFIIFVVYTMLPF 153
            .|  .|..| :.::::   ||:|:|..|     |:|.|.|.       |...:|::|:.|.|:|.
  Fly    90 IKDHHLPTLCYGILLFTASICVVSMPTL-----GSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPL 149

Human   154 NMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQ 218
            .:.:|:...:...|.| |.|:|....|...:.....|::||::|||..|:||.....:||.|.::
  Fly   150 QIWEAVAFGIALPSVH-ISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRR 213

Human   219 TYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYV 283
            |:.||.|||.||::::.|..:.||||||:||.|:||:||.:|:    .|.|||      ||.:|:
  Fly   214 TFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDIL----SPVAGQ------FHRIYI 268

Human   284 KRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP 348
            ::|.|||||:|||||||.|:|.||..|||.:||||||:|||:|.:|.|:||||||||||||||||
  Fly   269 QKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLP 333

Human   349 ISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLA 413
            ....:|||..|:|||||.:||..|.:||.|.:|||||:|:|.|||||:||:|||:||||:|||||
  Fly   334 EPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLA 398

Human   414 NHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHL-- 476
            ||||:||.|||||::..||:.|:|.|:||.|.||.|..||:.|.|.|:|:: |...||.|..|
  Fly   399 NHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIV-PPPHRRKPLMLNT 462

Human   477 --------------FRP--------RHTL------------------------------------ 483
                          ||.        .||:
  Fly   463 LGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGG 527

Human   484 DGAKMRAS-------------------VRMTRYLESWGAAKPFAHLHHRDSMTTENGKIST---- 525
            .|...|.|                   :|:.:.|.    |.|..|.....|:....|.:.:
  Fly   528 GGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILH----ATPPPHGMGYGSVVGSGGGVDSGISG 588

Human   526 --------------TDVPMG--------------QHNFQNRTLRTKSQKK---RFEEELNER--- 556
                          ..|.:|              :||.:|    .|||.|   :|:....:|
  Fly   589 GGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKN----NKSQSKVADKFKRPFRKRHSV 649

Human   557 -------------MIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCAC 608
                         :.|||:..:....  |||.:.|::|.|....:|:||.......|...:.|:.
  Fly   650 AAHHQPTNRVNRFLSQAINARSVDCD--KSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSL 712

Human   609 LIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIA 673
            |:......:|:..||:|.:|.:.|..||:.::.||.:..|.:|        ..::|.:..|..:
  Fly   713 LLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRL--------KWIIWDISESFSL- 768

Human   674 NRPWPRISLTIITTAIILMMAVFNMF-FLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFL 737
                 |:::||.|..:|..:...|:| .:||.     |.:....|||...:::..        .|
  Fly   769 -----RMAITIFTVILIYSVGQVNVFTCVSDH-----PCSGNGTTSFQNDSHRKC--------SL 815

Human   738 PYFI-YSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKD 801
            |.:: .|.....:|.|||||:....|.|:::.....|...:..:|.::...|.    .|......
  Fly   816 PQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYD----NRVNASIP 876

Human   802 LKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAE 866
            |..:....::||.|.:||.||..|...||||||:.:..:|::|::.::..|:.:|.|:||||||.
  Fly   877 LHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAA 941

Human   867 HFL-ARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKP 930
            ||| |:...|.|||||||..|.|:|||:|:|.|||||.|.:.:||||||||||||||||:||.:.
  Fly   942 HFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKED 1006

Human   931 KFSGVEKIKTIGSTYMAATGLSAVPSQE-HSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFND 994
            :|.|::||||:||||||..||  :|..: ...:|.....|:..::|:..|:...|..||.||:|:
  Fly  1007 RFRGIDKIKTVGSTYMAVVGL--IPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNN 1069

Human   995 FKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTC 1059
            |.||||||.|||:||||||:||||||||||||||||||||||....|||:|....|....:...|
  Fly  1070 FMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRC 1134

Human  1060 RGIINVKGKGDLKTYFVNTEMSRSLS 1085
            ||.|.||||||:.|||:....::||:
  Fly  1135 RGTIKVKGKGDMVTYFLCDSGNKSLN 1160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	195/423 (46%)
		Guanylate_cyc	281..465	CDD:425528	118/183 (64%)
		Adcy_cons_dom	495..600	CDD:461877	29/155 (19%)
		Guanylate_cyc	878..1077	CDD:425528	118/199 (59%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		12/16 (75%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		2/2 (100%)
rut	NP_511156.2	AC_N	<17..255	CDD:318454	75/235 (32%)
		Guanylate_cyc	266..428	CDD:425528	107/161 (66%)
		Adcy_cons_dom	624..698	CDD:461877	21/79 (27%)
		AcyC	742..1150	CDD:441717	182/440 (41%)
		Guanylate_cyc	954..1151	CDD:425528	117/198 (59%)