DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF274 and CG17806

DIOPT Version :9

Sequence 1:	NP_598009.1	Gene:	ZNF274 / 10782	HGNCID:	13068	Length:	653	Species:	Homo sapiens
Sequence 2:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	118/505 - (23%)
Similarity:	184/505 - (36%)	Gaps:	146/505 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   176 REALDQLRELCHQWL--QPKARSKEQILELLVLEQFLGALPVKLRT---WVESQHPENCQEVVAL 235
            |:.|..:.:|...||  ||...::..:..||.|...:......:||   |.|.|..:...:....
  Fly    24 RDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFRERCIRTNSSWFEKQGKQEDSDTETA 88

Human   236 VEGVT--WMSEEEVLP--AGQPAEGTTCCLEVTAQQEEKQE-------DAAICPVTVLPEEPVTF 289
            .||..  ..|..:|:|  ..||..     ..:..|:.:|.:       :..|.|: |:||.|..
  Fly    89 REGGNNRLESRVDVMPISIAQPQR-----RRILPQRSKKVDGVPLKTVETPIYPL-VVPEIPPA- 146

Human   290 QDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPE---EEPAPS 351
             |: ||..|.|..:...::.....|..:|:..|            :|  |.|::|:   |||.
  Fly   147 -DL-VDPLRCEDPIQVKSEPQLSSDYPVESMNH------------EE--PASEMPQVMKEEPR-- 193

Human   352 LKVQESSRDCALSSTLEDTLQ--GGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGAL-D 413
                              |||  |.||:                        ||....:.|.| :
  Fly   194 ------------------TLQVIGEVQK------------------------NRRKPRSKGCLEE 216

Human   414 TNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKA 478
            .....:.||:|.:|..|                         :.|..|:.:|.|.
  Fly   217 CPGKDMAKIENIDSTTN-------------------------KTKEEKYATRNKW---------- 246

Human   479 KEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKG 543
                |..|.......::.|           |.:|||.|.....|:||.:.|.|.:.:.||:|.:.
  Fly   247 ----GAAKRAYALEHRLYF-----------CDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRM 296

Human   544 FVQSSSLTQHQRV-HSGERPFECQECGRTFNDRSAISQHLRTHTGA---KPYKCQDCGKAFRQSS 604
            ......|..|.|: |.||.|:.|:.||:.|::......|.|.|..:   :|:.|..|.|||:.|:
  Fly   297 EFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPVHRPHVCSTCQKAFKTST 361

Human   605 HLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRT-HNRTK--RKKKQP 651
            .|..|...||||:|:.|..|...|.:.:.|..|.:: |:|.|  .:.|.|
  Fly   362 ALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKSKHHRLKVEEQSKMP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..159
		SCAN	157..269	CDD:128708	23/101 (23%)
		SCAN	157..245	CDD:280241	18/75 (24%)
		KRAB	287..>327	CDD:214630	8/39 (21%)
		KRAB	287..326	CDD:279668	8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..359		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414		4/26 (15%)
		COG5048	<389..644	CDD:227381	63/260 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..485		5/36 (14%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)
		C2H2 Zn finger	509..529	CDD:275368	8/19 (42%)
		zf-H2C2_2	521..546	CDD:290200	8/24 (33%)
		C2H2 Zn finger	537..557	CDD:275368	6/20 (30%)
		zf-H2C2_2	549..573	CDD:290200	10/24 (42%)
		zf-C2H2	563..585	CDD:278523	6/21 (29%)
		C2H2 Zn finger	565..585	CDD:275368	6/19 (32%)
		zf-C2H2	591..613	CDD:278523	8/21 (38%)
		C2H2 Zn finger	593..613	CDD:275368	8/19 (42%)
		zf-H2C2_2	605..630	CDD:290200	10/24 (42%)
		C2H2 Zn finger	621..641	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..653		7/23 (30%)
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	13/51 (25%)
		zf-C2H2	260..282	CDD:278523	9/32 (28%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	30/84 (36%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		ZnF_U1	375..407	CDD:197732	9/31 (29%)
		C2H2 Zn finger	378..396	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960