DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF234 and CG5245

DIOPT Version :9

Sequence 1:	NP_001138296.1	Gene:	ZNF234 / 10780	HGNCID:	13027	Length:	700	Species:	Homo sapiens
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	183/448 - (40%)
Similarity:	262/448 - (58%)	Gaps:	8/448 - (1%)

- Green bases have known domain annotations that are detailed below.

Human   231 PFKCVECGKGFSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTGEKPFKCDTCGK 295
            |.|...|      :|.:.....|......:.|.:|.:.|....:|:.|.|:|..|:||:|..|.|
  Fly    59 PSKLKTC------KSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSK 117

Human   296 NFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECGKCFIQPSQFQ 360
            :|.||:....|.:.|. ::|:||..|.|.||.:|:|:.|...||||:|:||.:|...|.:.|..|
  Fly   118 SFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQ 181

Human   361 AHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFRMKIHYQVHLVVHTGE 425
            .|.|.|:.|:|:.|..|.|.|..:|..|.|...|...:|:||:.|.|||:::...|.||:.| .|
  Fly   182 VHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AE 245

Human   426 KPYKCEVCGKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECG 490
            :.:||..|.|.|.|:..|:|||:.|:.:.||||..|.:.|.::||||:|.|.|.|::|.||.:|.
  Fly   246 RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCS 310

Human   491 KGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPFKCEECGKSFSRSAHL 555
            ..|:.|:..::|.|:||.|:.|.|.||.|.|.:.|||:.||:||:||:||||..|.|.|....||
  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375

Human   556 QAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGECGKHFSQASSLQLHQSVHTG 620
            :.|...|.|||..||..|.|.||.|..|.:|.:.|||:..:.|..|.|.::.:|:|.:|...|||
  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440

Human   621 EKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRFSWRSNLVSHHKIHAAGT 678
            |.|:||..|.|:|:||::.|.|.|.|||||||||..|..|::.:|:|..|.:....||
  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGT 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF234	NP_001138296.1	KRAB	8..65	CDD:214630
		KRAB	8..47	CDD:279668
		KRNB	91..147
		COG5048	<101..306	CDD:227381	21/74 (28%)
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		zf-C2H2	204..226	CDD:278523
		C2H2 Zn finger	206..226	CDD:275368
		zf-H2C2_2	218..243	CDD:290200	3/11 (27%)
		C2H2 Zn finger	234..254	CDD:275368	2/19 (11%)
		COG5048	258..672	CDD:227381	176/413 (43%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		zf-H2C2_2	274..299	CDD:290200	11/24 (46%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		zf-H2C2_2	330..355	CDD:290200	11/24 (46%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		zf-H2C2_2	359..383	CDD:290200	10/23 (43%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		C2H2 Zn finger	402..422	CDD:275368	8/19 (42%)
		zf-H2C2_2	414..439	CDD:290200	10/24 (42%)
		C2H2 Zn finger	430..450	CDD:275368	9/19 (47%)
		C2H2 Zn finger	458..478	CDD:275368	9/19 (47%)
		zf-H2C2_2	471..495	CDD:290200	11/23 (48%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		zf-H2C2_2	498..523	CDD:290200	11/24 (46%)
		C2H2 Zn finger	514..534	CDD:275368	10/19 (53%)
		zf-H2C2_2	526..551	CDD:290200	15/24 (63%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		zf-H2C2_2	554..578	CDD:290200	11/23 (48%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		zf-H2C2_2	582..607	CDD:290200	8/24 (33%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		zf-H2C2_2	610..635	CDD:290200	12/24 (50%)
		C2H2 Zn finger	626..646	CDD:275368	9/19 (47%)
		zf-H2C2_2	639..662	CDD:290200	14/22 (64%)
		C2H2 Zn finger	654..674	CDD:275368	6/19 (32%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	172/405 (42%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810