Protein Alignment ZNF234 and CG5245

DIOPT Version :10

• Sequence 1: NP_006621.1
• Gene: ZNF234 / 10780
• HGNCID: 13027
• Length: 700
• Species: Homo sapiens
• Sequence 2: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 448
• Identity: 183/448 - (40%)
• Similarity: 262/448 - (58%)
• Gaps: 8/448 - (1%)

Human   231 PFKCVECGKGFSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTGEKPFKCDTCGK 295
            |.|...|      :|.:.....|......:.|.:|.:.|....:|:.|.|:|..|:||:|..|.|
  Fly    59 PSKLKTC------KSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSK 117

Human   296 NFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECGKCFIQPSQFQ 360
            :|.||:....|.:.|. ::|:||..|.|.||.:|:|:.|...||||:|:||.:|...|.:.|..|
  Fly   118 SFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQ 181

Human   361 AHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFRMKIHYQVHLVVHTGE 425
            .|.|.|:.|:|:.|..|.|.|..:|..|.|...|...:|:||:.|.|||:::...|.||:.| .|
  Fly   182 VHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AE 245

Human   426 KPYKCEVCGKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECG 490
            :.:||..|.|.|.|:..|:|||:.|:.:.||||..|.:.|.::||||:|.|.|.|::|.||.:|.
  Fly   246 RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCS 310

Human   491 KGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPFKCEECGKSFSRSAHL 555
            ..|:.|:..::|.|:||.|:.|.|.||.|.|.:.|||:.||:||:||:||||..|.|.|....||
  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375

Human   556 QAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGECGKHFSQASSLQLHQSVHTG 620
            :.|...|.|||..||..|.|.||.|..|.:|.:.|||:..:.|..|.|.::.:|:|.:|...|||
  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440

Human   621 EKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRFSWRSNLVSHHKIHAAGT 678
            |.|:||..|.|:|:||::.|.|.|.|||||||||..|..|::.:|:|..|.:....||
  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGT 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF234	NP_006621.1	KRAB	8..65	CDD:214630
		KRNB	91..147
		COG5048	<101..306	CDD:227381	21/74 (28%)
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		SUF4-like	202..>251	CDD:411020	4/19 (21%)
		C2H2 Zn finger	203..231	CDD:411020	183/448 (41%)
		C2H2 Zn finger	206..226	CDD:275368
		C2H2 Zn finger	234..254	CDD:275368	2/19 (11%)
		C2H2 Zn finger	234..251	CDD:411020	2/16 (13%)
		COG5048	258..672	CDD:227381	176/413 (43%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		C2H2 Zn finger	402..422	CDD:275368	8/19 (42%)
		C2H2 Zn finger	430..450	CDD:275368	9/19 (47%)
		C2H2 Zn finger	458..478	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		C2H2 Zn finger	514..534	CDD:275368	10/19 (53%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		C2H2 Zn finger	626..646	CDD:275368	9/19 (47%)
		C2H2 Zn finger	654..674	CDD:275368	6/19 (32%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	172/405 (42%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)