DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF234 and CG11247

DIOPT Version :9

Sequence 1:	NP_001138296.1	Gene:	ZNF234 / 10780	HGNCID:	13027	Length:	700	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	121/371 - (32%)
Similarity:	183/371 - (49%)	Gaps:	28/371 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   290 CDTCGKNFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIH-QRVHTGEKPYKCEECGKCF 353
            |..|.|.|..::.|..|.::|:.|:|:||:||||.:..:.||:.| ...|...|.:.|.:|.|.|
  Fly    95 CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSF 159

Human   354 IQPSQFQAHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVH--TGEKPYKCNECGKSFRMKIHYQ 416
            ....:.:.|.|:|:|||||.|.:|.|.|......|.|...|  |..:.:.|.:|..||....:.:
  Fly   160 ALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLR 224

Human   417 VHLVVHTGEKPYKCEVCGKAFRQSSYLKIHL-KAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTG 480
            ||:..|.....::|.:|...|.....|:.|: :.|.....|:||.|.:.......|..|...||.
  Fly   225 VHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTA 289

Human   481 EKPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPFKCEEC 545
            .|.:.||.|...|::::...:|.|:||||:||.|..|.:.|:.:|.|..|.|.|:|||||:|:.|
  Fly   290 VKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC 354

Human   546 GK--SFSRSAHLQAH-QKVHTGEKPYKCGECGKGFKWSLNLDMHQRVH------TGEKPYTCGEC 601
            ..  :||:.|||:.| :|:|..:|||.|..|...||..:.|..|.. |      .|:||  .|..
  Fly   355 EDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGDKP--SGNQ 416

Human   602 GKHFSQASSLQLHQSVHTGEKPYKCDVCGKVFS--RSSQLQYHRRV 645
            .:.....|.|:.:.:|          |..|:.|  :..||.|.:|:
  Fly   417 SEDAQILSVLRFNMAV----------VLKKISSAQKLRQLGYEKRL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF234	NP_001138296.1	KRAB	8..65	CDD:214630
		KRAB	8..47	CDD:279668
		KRNB	91..147
		COG5048	<101..306	CDD:227381	5/15 (33%)
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		zf-C2H2	204..226	CDD:278523
		C2H2 Zn finger	206..226	CDD:275368
		zf-H2C2_2	218..243	CDD:290200
		C2H2 Zn finger	234..254	CDD:275368
		COG5048	258..672	CDD:227381	121/371 (33%)
		C2H2 Zn finger	262..282	CDD:275368
		zf-H2C2_2	274..299	CDD:290200	4/8 (50%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	318..338	CDD:275368	8/20 (40%)
		zf-H2C2_2	330..355	CDD:290200	9/25 (36%)
		C2H2 Zn finger	346..366	CDD:275368	6/19 (32%)
		zf-H2C2_2	359..383	CDD:290200	12/23 (52%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		zf-H2C2_2	414..439	CDD:290200	6/24 (25%)
		C2H2 Zn finger	430..450	CDD:275368	5/20 (25%)
		C2H2 Zn finger	458..478	CDD:275368	5/19 (26%)
		zf-H2C2_2	471..495	CDD:290200	9/23 (39%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		zf-H2C2_2	498..523	CDD:290200	11/24 (46%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..551	CDD:290200	12/26 (46%)
		C2H2 Zn finger	542..562	CDD:275368	9/22 (41%)
		zf-H2C2_2	554..578	CDD:290200	10/24 (42%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		zf-H2C2_2	582..607	CDD:290200	7/30 (23%)
		C2H2 Zn finger	598..618	CDD:275368	3/19 (16%)
		zf-H2C2_2	610..635	CDD:290200	5/26 (19%)
		C2H2 Zn finger	626..646	CDD:275368	7/22 (32%)
		zf-H2C2_2	639..662	CDD:290200	3/7 (43%)
		C2H2 Zn finger	654..674	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/151 (33%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000