DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AHCYL1 and AhcyL1

DIOPT Version :9

Sequence 1:	NP_006612.2	Gene:	AHCYL1 / 10768	HGNCID:	344	Length:	530	Species:	Homo sapiens
Sequence 2:	NP_647746.1	Gene:	AhcyL1 / 38342	FlyBaseID:	FBgn0035371	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	370/477 - (77%)
Similarity:	418/477 - (87%)	Gaps:	4/477 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    57 KTGRRSLSRSISQSSTDSYSSAASYTDSSD--DEVSPREKQQTNSKGSSNFCVKNI-KQAEFGRR 118
            |...|..|||:|.|||||:|| ||||.||:  |:|.||||.|.||||||:|||:|| .|..||||
  Fly    46 KKTSRYRSRSLSASSTDSFSS-ASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRR 109

Human   119 EIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQ 183
            |||||||:|..:|:|:|||..:|||..|||||||||.||||||||||..|||..||:||||||||
  Fly   110 EIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQ 174

Human   184 NEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKI 248
            |||||||||:|:.:|||:||:|:|||||||||||.:.||.|||||||||.||.:.||||.:||.:
  Fly   175 NEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLV 239

Human   249 RGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQ 313
            :||||||||||||||||||||||.||||||||||||.||||||.|:|||||.|||:|||||||||
  Fly   240 KGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQ 304

Human   314 VVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKN 378
            |||||||:|||||..|||..|.|||||||||||||||.||||||||||||||.||:|:|.|||||
  Fly   305 VVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKN 369

Human   379 VVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLL 443
            ||.|||:|:||:.|||||||||||||||..||||:||||:|||||||:|||:||.::|||||||:
  Fly   370 VVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLV 434

Human   444 NLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELT 508
            |||||::|:|.:|||:.|||||||||:|||.||||.|||||||||||||||||||:||||||||:
  Fly   435 NLSCSSIPSFAVSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELS 499

Human   509 DDQAKYLGLNKNGPFKPNYYRY 530
            |:||||:||||.||||||||||
  Fly   500 DEQAKYMGLNKAGPFKPNYYRY 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AHCYL1	NP_006612.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..103		30/47 (64%)
		PEST. /evidence=ECO:0000269\|PubMed:25237103	65..92		18/28 (64%)
		AdoHcyase	106..529	CDD:214963	334/423 (79%)
		Interaction with BCL2L10. /evidence=ECO:0000269\|PubMed:27995898	138..201		47/62 (76%)
		NAD binding. /evidence=ECO:0000250	281..448		135/166 (81%)
		PDZ-binding. /evidence=ECO:0000250	520..530		8/9 (89%)
AhcyL1	NP_647746.1	AdoHcyase	94..520	CDD:336064	335/425 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147784
Domainoid	1	1.000	282	1.000	Domainoid score	I1661
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77353
Inparanoid	1	1.050	774	1.000	Inparanoid score	I533
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48638
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	1	1.000	-	-		otm41371
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5762
SonicParanoid	1	1.000	-	-		X2437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800