Protein Alignment TOB2 and Tob

DIOPT Version :10

• Sequence 1: NP_057356.1
• Gene: TOB2 / 10766
• HGNCID: 11980
• Length: 344
• Species: Homo sapiens
• Sequence 2: NP_573104.1
• Gene: Tob / 32574
• FlyBaseID: FBgn0028397
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 442
• Identity: 149/442 - (33%)
• Similarity: 208/442 - (47%)
• Gaps: 124/442 - (28%)

Human     1 MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHIGEMVD 65
            |.:||:|||||:||||||||||||.::||||||:.|:.|::.|||||||.|||.:||:..|:.:|
  Fly     1 MHIEIQVALNFVISYLYNKLPRRRVNIFGEELEKALRDKFQDHWYPEKPFKGSAYRCLKTGDPID 65

Human    66 PVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGC-GAPELDKEI 129
            .|:|.||:.||:.:.|:..|:|.||||||||.|||::||||||||:||.:::|.. .:...|:|:
  Fly    66 SVLERAARESGVPIGDILENLPNELSVWIDPGEVSFRIGEKGAVKILYTENNENHEDSHSADREV 130

Human   130 KSSFNPDAQVFVPIGSQDSSLSN-------------------SPSPSFGQSPSPT---------- 165
            ...|||:||.|.||.:.:::::|                   |.||::..||:.|
  Fly   131 TKMFNPEAQCFRPIDAVNTTMNNMSLSPKGHHQSGSSPHSAASSSPTYKGSPNRTISGSCSSVSG 195

Human   166 ---------------------------------------FIPRSAQ-PITFTTASFAATKFGSTK 190
                                                   |:.|.|| |:|||||:||.|||||||
  Fly   196 AGSGTGSGSRSGSNHAPGPGTAPGPVPGNGATANAAAAAFMQRGAQAPLTFTTATFAQTKFGSTK 260

Human   191 MKKG--------------------------------GGAA--SGGGVASSGAGGQQPPQQPRMAR 221
            :|..                                |.|.  |.|...|:..||..       |.
  Fly   261 LKTSSKRTNSSSAYRMSPTEFSNYIKQRAMQQQMHHGHAVVPSAGSSVSAAYGGMD-------AV 318

Human   222 SPTNSLLKHKSLSLSMHSLNFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPF 286
            ||..| |....|||:.:....::.:.| .|...||....:|...|:|...|::.......:.|.:
  Fly   319 SPARS-LSPNPLSLAGNQNQSVSGSSA-DSYYYPNMPINMYPQYGNPRCLFESHFSADVSSMGLY 381

Human   287 GGSGAGTCNSSSFDMAQVFGGGAN--SLFLEKTPFVEGLSYNLNTMQYPSQQ 336
            ....||..      :..|...|||  |.:||...:..|   :.||.|:..||
  Fly   382 VSGTAGAA------VTAVGSVGANKYSTYLEPCYYGNG---HANTQQHSQQQ 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOB2	NP_057356.1	BTG	1..106	CDD:472808	64/104 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..169		8/92 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..225		11/67 (16%)
Tob	NP_573104.1	BTG	1..113	CDD:462251	70/111 (63%)