DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAPN9 and capn9

DIOPT Version :9

Sequence 1:	XP_011542319.1	Gene:	CAPN9 / 10753	HGNCID:	1486	Length:	721	Species:	Homo sapiens
Sequence 2:	NP_001121483.1	Gene:	capn9 / 100158582	XenbaseID:	XB-GENE-948345	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	661	Identity:	470/661 - (71%)
Similarity:	586/661 - (88%)	Gaps:	0/661 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPF 65
            |||:|:.|..:.....:..|..||||:::||::.:||::|.||||.||||::|||||||:|.:||
Frog     1 MPYIYQDPSLKESIAQQTPRSIHSSGKTYEQLKNDCLRKGVLFEDVDFPANDSSLFYSEKPSVPF 65

Human    66 VWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGI 130
            |||||.|:|.:||||||||:|||:|||:||||||||||||||||.|.|.||:|.||||..|||||
Frog    66 VWKRPKEMVADPEFILGGASRTDVCQGDLGDCWLLAAIASLTLNDKILYRVVPPDQSFSTGYAGI 130

Human   131 FHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEA 195
            ||||||||:|||||||||||||||:||||:||||.||||||||||||||||||||||||||.:||
Frog   131 FHFQFWQHNEWLDVVIDDRLPTFRNRLVFVHSADLNEFWSALLEKAYAKLNGSYEALKGGSTLEA 195

Human   196 MEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
            ||||||||.||::.:.||.|.::||:||:|:||:|||.||..|:||:||:||.||:||||||:||
Frog   196 MEDFTGGVTETYEIRSAPANLFDILDKAIKKGSMLGCSIDITSSAETEAKTPQGLVKGHAYSITG 260

Human   261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFK 325
            .|.|:|:||:::|||||||||||||||:|||:|.||..:|.||:.||...:||||||||.|:|||
Frog   261 ADVVNFKGQKVKLIRIRNPWGQVEWNGAWSDNSSEWNIIGAAEKNRLSQASLDDGEFWMDFEDFK 325

Human   326 AHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEG 390
            .||||:||||||||:|::||.||||||||:|||:||||||||||||:|||:||||||||||:|:|
Frog   326 RHFDKLEICNLTPDSLDDDAKHKWEVTVHEGSWIRGSTAGGCRNFLETFWSNPQIKLSLTEQDDG 390

Human   391 QEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREV 455
            |:||:|:.|||||:||||::.||::|||||.||:||..:..|:||||:::.|:|||||::||||:
Frog   391 QKECTFIAALMQKNRRKLRKTGADLLTIGYTIYQCPGSESILSKDFFKFNPSKARSKTYVNLREI 455

Human   456 SDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEE 520
            |.|||||||:|:.||:||||||||||||||||||||..::|||.|:||||:||.||||.:|||||
Frog   456 SQRFKLPPGDYMFIPTTFEPHQEADFCLRIFSEKKADIKEMDGEVNIDLPDPPAPTPPHKETEEE 520

Human   521 QRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDE 585
            ::||.||||::|:|:||:||||:|||||||::.|:||||::||:||.|||||||.||||||.|||
Frog   521 RQFRTLFEQISGQDLEVSAEELQYVLNAVLRRTKNIKFKEMSLLSCNNIISLMDASGNGKLGFDE 585

Human   586 FKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDD 650
            ||:||||||.||.:|:::|.|||||||:||||.|||:|||.|::.:||||||||||::.|::|||
Frog   586 FKIFWDKLKTWIGIFMQYDLDKSGTMSSYELRLALKSAGFHLNNIVLQLIVLRYADDQFQIEFDD 650

Human   651 FLNCLVRLENA 661
            ||||||||||:
Frog   651 FLNCLVRLENS 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPN9	XP_011542319.1	Peptidase_C2	43..335	CDD:279042	218/291 (75%)
		Calpain_III	349..491	CDD:279416	104/141 (74%)
		PTZ00184	514..657	CDD:185504	100/142 (70%)
		EFh	566..621	CDD:238008	41/54 (76%)
		EFh	600..652	CDD:298682	34/51 (67%)
capn9	NP_001121483.1	Peptidase_C2	43..335	CDD:366222	218/291 (75%)
		Calpain_III	356..491	CDD:366446	98/134 (73%)
		EFh_PEF_CAPN9	522..691	CDD:320067	100/140 (71%)
		EF-hand motif	522..550	CDD:320067	19/27 (70%)
		EF-hand motif	565..594	CDD:320067	24/28 (86%)
		EF-hand motif	595..625	CDD:320067	19/29 (66%)
		EF-hand motif	631..659	CDD:320067	21/27 (78%)
		EF-hand motif	661..691	CDD:320067	0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I3969
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H38208
Inparanoid	1	1.050	1060	1.000	Inparanoid score	I2811
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103148at7742
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		oto158628
Panther	1	1.100	-	-	LDO	PTHR10183
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2435
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190