DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHL1 and Cont

DIOPT Version :9

Sequence 1:	NP_006605.2	Gene:	CHL1 / 10752	HGNCID:	1939	Length:	1224	Species:	Homo sapiens
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1045	Identity:	275/1045 - (26%)
Similarity:	453/1045 - (43%)	Gaps:	122/1045 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    35 PTIIKQSKVQVAFPFDEYFQI-----------ECEAKGNPEPTFSWTKDGNPFYFTD----HRII 84
            |..:||       |.|..|.:           .|.|.|.|.|:::|.::   .|..|    .:|.
  Fly   362 PYFVKQ-------PNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYRE---VYVDDRLEYQKID 416

Human    85 PSNN-----SGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFP-KEKIDPLEV 143
            |...     ||...|..|...:..||.|.|.|.||.|...||........:.:|. |...:..|:
  Fly   417 PLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEM 481

Human   144 EEGDPIVLPCNPPKGLPPLHIYWMNIELEH-IEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAA 207
            ..|..|.  |:||:..|.:..||......: :|:|:||::|:.|.|||:.:|..| |.:|.|
  Fly   482 NWGKSIF--CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSC--- 540

Human   208 FPRLRTIVQK-------MPMKLTVNS----LKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESG 261
              .::|:|..       .|:::|.||    |..||..                 ||:......:|
  Fly   541 --TVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTF-----------------PKVFPEAPVAG 586

Human   262 SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRC 326
            .|          :.|||.|.|.|.|..:|.:.|..|.:...| .|||:.|.|:|.:..|.|.|.|
  Fly   587 DE----------IRLECMAFGYPIPSYNWTRQGLPLQRNAYT-INYGRVLIIQNATTNDNGEYSC 640

Human   327 TASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHP 391
            |.:|...|.....::.::..|::|...:..:....|:...:|||...|.....|..|...:|...
  Fly   641 TITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPAN 705

Human   392 FAGD--VVFPREISFTNLQPN-HTAVYQCEASNVHGTILANANIDVVDVRPLIQTK--DGENYAT 451
            ...|  ::....::...|:.: ..|:|||.|.|...|..::|.:.|:.::|..:..  :.|.||.
  Fly   706 INRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAV 770

Human   452 VVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAI 516
            ..|.:..: |:..|:|.....|:|..:|....|.| .|..:|||.|:.|:.:|.|.|:|...|..
  Fly   771 YNGNTTIV-CDPEAAPRPKFQWKKDGQVIGSGGHR-RILPSGTLTISPTSRDDEGIYTCIASNQA 833

Human   517 GKTAVTANLDIRNATKLRVSPKNPRIPKLH-MLELHCESKCDSHLKHSLKLSWSKDGEAFEINGT 580
            |.....|.:.:....:...:|....:.|.| ::.||||:..|..|  .:...|..:||..:.|..
  Fly   834 GTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELL--DIAYVWKHNGEVLKNNHD 896

Human   581 EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVR 645
            ..||||:|...||:.|.::.|.|.|.|...:|::..:..|.|::...|..|..:.:.:.......
  Fly   897 GTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAI 961

Human   646 LTWEAGADHNSNISEYIVEFEGNKEEPGRW---------EELTRVQGKKTTVILPLAPFVRYQFR 701
            :.|..|: ||.....| ....|.......|         .|:.|...::...::.|.|:..|:|.
  Fly   962 IEWVDGS-HNGRAIRY-YNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFS 1024

Human   702 VIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVT 766
            |.|||::|...||.||..:.|....|...|:|:.....:..::.|.|:||...||:..|:.|:|.
  Fly  1025 VTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVF 1089

Human   767 WKPQGAPVEWEEETVTNH------TLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYP 825
            ||.:|| :||..:.:...      .:.:.....|..|:|||||||.:|.||:.:...::|.||.|
  Fly  1090 WKLKGA-IEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMP 1153

Human   826 DTAPVIHGVDVINSTLVKVTWSTV--PKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFS- 887
            ..||........|||...|||..:  .::.:.|:|.|:::.:|||       ||.:|.::...|
  Fly  1154 QVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKT-------THQEEDSVYYLSR 1211

Human   888 GQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFLKVIKVDKDTATLS 951
            ..||..::..|...:.:.:.|:|||:.|.|||||.:..:|....|:: |:.:.|..::..|..:.
  Fly  1212 TTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVV 1276

Human   952 WGL--PKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTS 1014
            |..  |.:....:.||  :.:|......:...|:..:....|...:::||.....|...:.|.::
  Fly  1277 WRYVSPSQDEEPVEGY--KVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSN 1339

Human  1015 QGCGK 1019
            .|.|:
  Fly  1340 GGDGR 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHL1	NP_006605.2	Ig	55..126	CDD:299845	24/90 (27%)
		Ig2_L1-CAM_like	129..223	CDD:143253	28/102 (27%)
		IG_like	140..224	CDD:214653	26/91 (29%)
		IG_like	264..343	CDD:214653	24/78 (31%)
		Ig3_L1-CAM_like	274..344	CDD:143208	24/69 (35%)
		IG_like	353..434	CDD:214653	18/83 (22%)
		Ig4_L1-NrCAM_like	361..435	CDD:143179	18/76 (24%)
		IG_like	447..525	CDD:214653	25/77 (32%)
		Ig	457..525	CDD:299845	21/67 (31%)
		IG_like	548..624	CDD:214653	25/75 (33%)
		Ig	548..616	CDD:143165	23/67 (34%)
		DGEA	571..574		1/2 (50%)
		FN3	628..717	CDD:238020	22/97 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..732		7/22 (32%)
		fn3	731..811	CDD:278470	27/85 (32%)
		FN3	834..927	CDD:238020	29/95 (31%)
		FN3	932..1027	CDD:238020	17/91 (19%)
		Bravo_FIGEY	1120..1205	CDD:290593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1179
		FIG[AQ]Y	1197..1201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1224
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	30/107 (28%)
		I-set	362..462	CDD:254352	30/109 (28%)
		Ig	466..559	CDD:299845	28/100 (28%)
		IG_like	584..657	CDD:214653	26/83 (31%)
		IGc2	586..645	CDD:197706	24/69 (35%)
		Ig	667..751	CDD:299845	18/83 (22%)
		IG_like	676..751	CDD:214653	18/74 (24%)
		IG_like	765..844	CDD:214653	25/80 (31%)
		Ig	773..844	CDD:299845	22/72 (31%)
		I-set	851..940	CDD:254352	28/90 (31%)
		Ig	866..944	CDD:299845	25/79 (32%)
		FN3	944..1043	CDD:238020	24/100 (24%)
		FN3	1053..1146	CDD:238020	29/93 (31%)
		fn3	1156..1244	CDD:278470	28/94 (30%)
		fn3	1259..1346	CDD:278470	16/88 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11028
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810