DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHL1 and Nrg

DIOPT Version :9

Sequence 1:	NP_006605.2	Gene:	CHL1 / 10752	HGNCID:	1939	Length:	1224	Species:	Homo sapiens
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	1302	Identity:	367/1302 - (28%)
Similarity:	568/1302 - (43%)	Gaps:	161/1302 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    14 LMFLLLKFSKAIEIPSSVQQVPTIIKQS-------KV-QVAFPFDEYFQIECEAKGNPEPTFSWT 70
            |..||:....|....|...:.|.|.||.       || |.....|..|.|||||.|.|||.:||.
  Fly     8 LAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWI 72

Human    71 KDGNPFYFT--DHRIIPSNNSGT--FRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVP 131
            |:|..|.:.  |:|::.....||  ..||.:    ..:|.|:|||||:.|.|.|..:......:.
  Fly    73 KNGKKFDWQAYDNRMLRQPGRGTLVITIPKD----EDRGHYQCFASNEFGTATSNSVYVRKAELN 133

Human   132 KFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIE------QDERVYMSQKGDLYF 190
            .|..|....||..||:|.:|.|..|.|.|...:.|| |: |.|:      .:.|:.:..:|:|:|
  Fly   134 AFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWM-IQ-ESIDGSIKSINNSRMTLDPEGNLWF 196

Human   191 ANVEEKDSRND--YCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKL 253
            :||..:|:.:|  |.|.|      |.|.:...|:....|....      ::|..|:..|.
  Fly   197 SNVTREDASSDFYYACSA------TSVFRSEYKIGNKVLLDVK------QMGVSASQNKH----- 244

Human   254 LLPPT-ESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLP-KGRETKENYGKTLKIENV 316
              ||. :..|......|:|:.:.|.|...|.|.||..|:|.|..:. ..|.|:.:|||:|.|...
  Fly   245 --PPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQT 307

Human   317 SYQDKGNYRCTASNFLGTATHDFHVI--VEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIK 379
            ::.|.|.|.|..||.:|.| ..|.:|  |...|.:||:|:.|..:.....:..|.|.|.|:|.|.
  Fly   308 NFDDAGTYTCDVSNGVGNA-QSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKIS 371

Human   380 WRVNGSPVD-NHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQT 443
            |..||.|:: :.|.....|....|...||....|..|.|.|:|..|.:..:..::|....|.|..
  Fly   372 WIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISE 436

Human   444 KDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSY 508
            .... .:||.|.:..:.|....||:.:|.|.:....  |.|.||::..||.|:|...|..|||.|
  Fly   437 APAA-VSTVDGRNVTIKCRVNGSPKPLVKWLRASNW--LTGGRYNVQANGDLEIQDVTFSDAGKY 498

Human   509 SCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGE 573
            :|:.:|..|:.....:|.::..|::...|:|..:.........|....|..|:  :::.|.|||:
  Fly   499 TCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLE--IEIDWWKDGQ 561

Human   574 AFEING------TEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPE 632
            :.:...      |.|.       :|||:.....|.|.|.|.|.|.||.|.....:.|.|||:.|:
  Fly   562 SIDFEAQPRFVKTNDN-------SLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPK 619

Human   633 NLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE-ELTRVQGKKTTVILPLAPFV 696
            ...::.:.::: .:.||...|:.|.|..|.::| .....|..|: ...:|....::.::.::|:.
  Fly   620 LTGITCQADKA-EIHWEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVPNTDSSFVVQMSPWA 682

Human   697 RYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGL 761
            .|.|||||.|::|.|.||..||...|.|..|.:||.|:..|.::|..::|.|.|:..:|.|.|..
  Fly   683 NYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNF 747

Human   762 EYRVTWKPQGAPVEWEEETV---TNHTLRVMTPAVYAPYDVKVQAINQLG-SGPDPQSVTLYSGE 822
            .|.|:||.......||...:   ..:.:.:.....:..|.:||.|||..| |....:.|..||||
  Fly   748 HYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGE 812

Human   823 DYPDTAPVIHGV-DVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRF 886
            |.|..||....: .:.:||...:.|:.|.::.|.|..|||:|..|...   :|....:|:::
  Fly   813 DRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTEN---EGEEGLREIHV--- 871

Human   887 SGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLS 951
            .|..::.:|......|:.:..:||||.:..||.|....|.||||||.....|....:......|.
  Fly   872 KGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLH 936

Human   952 WGLPKKLNGNLTGYLLQYQIINDTYEIGELN--DINITTPSKPSWHLSNLNATTKYKFYLRACTS 1014
            |..|...||.||||.:.|:.:.::| :||..  |.:||.|......::.|...:||:..:.|.|.
  Fly   937 WKKPLYPNGKLTGYKIYYEEVKESY-VGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTK 1000

Human  1015 QGCGKPITEESSTLGE-----------------GSKGIGKISGVNLTQKTHPIEVFEPGAE---- 1058
            .|.|.....|.:||.:                 ...|:.|.. :|....|..    .||..
  Fly  1001 MGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFR-INWLPSTEG----HPGTHFFTM 1060

Human  1059 HIVRLMTKNWGDNDSIFQDVIETRGREYAGLY--------------------------------- 1090
            |.::..|:...:|:....|..|..|.:....|
  Fly  1061 HRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVAN 1125

Human  1091 DDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKE---DLHPDPEIQSVKDETFGEY 1152
            :.::..|||||:|.|:|.:.:|.:.:|.::|||||||.|.::|   .....||     :..|.||
  Fly  1126 ETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPE-----EGGFHEY 1185

Human  1153 SDSDEKPLKG--SLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGS 1215
            |...:....|  |:.|.|:....::: ||:.|||:||..:     :...|.|.:..:..:.|..:
  Fly  1186 SQPLDNKSAGRQSVSSANKPGVESDT-DSMAEYGDGDTAV-----ATAAARAAAAARSKLTSLPT 1244

Human  1216 ST 1217
            ||
  Fly  1245 ST 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHL1	NP_006605.2	Ig	55..126	CDD:299845	30/74 (41%)
		Ig2_L1-CAM_like	129..223	CDD:143253	31/101 (31%)
		IG_like	140..224	CDD:214653	29/91 (32%)
		IG_like	264..343	CDD:214653	28/81 (35%)
		Ig3_L1-CAM_like	274..344	CDD:143208	26/72 (36%)
		IG_like	353..434	CDD:214653	23/81 (28%)
		Ig4_L1-NrCAM_like	361..435	CDD:143179	21/74 (28%)
		IG_like	447..525	CDD:214653	24/77 (31%)
		Ig	457..525	CDD:299845	21/67 (31%)
		IG_like	548..624	CDD:214653	21/81 (26%)
		Ig	548..616	CDD:143165	20/73 (27%)
		DGEA	571..574		2/2 (100%)
		FN3	628..717	CDD:238020	24/89 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..732		10/22 (45%)
		fn3	731..811	CDD:278470	24/83 (29%)
		FN3	834..927	CDD:238020	24/93 (26%)
		FN3	932..1027	CDD:238020	27/96 (28%)
		Bravo_FIGEY	1120..1205	CDD:290593	28/89 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1179		8/33 (24%)
		FIG[AQ]Y	1197..1201		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1224		3/13 (23%)
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	31/76 (41%)
		IG_like	57..127	CDD:214653	30/73 (41%)
		Ig	135..214	CDD:299845	27/80 (34%)
		IG_like	141..216	CDD:214653	26/82 (32%)
		ig	251..332	CDD:278476	28/81 (35%)
		I-set	339..427	CDD:254352	26/87 (30%)
		Ig	354..427	CDD:299845	21/72 (29%)
		I-set	432..517	CDD:254352	27/87 (31%)
		Ig	446..517	CDD:299845	23/72 (32%)
		I-set	522..611	CDD:254352	23/97 (24%)
		ig	525..609	CDD:278476	23/92 (25%)
		FN3	613..707	CDD:238020	28/95 (29%)
		FN3	716..807	CDD:238020	25/90 (28%)
		fn3	817..905	CDD:278470	24/93 (26%)
		FN3	917..1004	CDD:238020	25/87 (29%)
		FN3	1041..1111	CDD:238020	11/74 (15%)
		Bravo_FIGEY	1155..>1221	CDD:290593	24/71 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9917
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	603	1.000	Inparanoid score	I950
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm40969
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740