Protein Alignment GRAP and drk

DIOPT Version :10

• Sequence 1: NP_006604.1
• Gene: GRAP / 10750
• HGNCID: 4562
• Length: 217
• Species: Homo sapiens
• Sequence 2: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 119/219 - (54%)
• Similarity: 150/219 - (68%)
• Gaps: 12/219 - (5%)

Human     1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPWYSGRI 65
            ||::|.:.|.||..|||:|.|...|||||||||.|||:|||.|.||.||.|||.:|.|.||.|||
  Fly     1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRI 65

Human    66 SRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEKFNSLNE 130
            :|..||::|..: |.||||||.||||||:||:||...|.||||||||:|..|:|||..|||||||
  Fly    66 TRADAEKLLSNK-HEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNE 129

Human   131 LVDFYRTTTIAKKRQIFLRD---EEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPD 192
            ||:::||.::::.:.:.|||   ||.|:        ||.:||..|:..:|.|||||:|.|.:|.|
  Fly   130 LVEYHRTASVSRSQDVKLRDMIPEEMLV--------QALYDFVPQESGELDFRRGDVITVTDRSD 186

Human   193 PHWWRGRSCGRVGFFPRSYVQPVH 216
            .:||.|....|.|.||.:||.|.|
  Fly   187 ENWWNGEIGNRKGIFPATYVTPYH 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRAP	NP_006604.1	SH3_GRAP_N	2..55	CDD:212881	33/52 (63%)
		SH2_Grb2_like	56..150	CDD:199828	54/93 (58%)
		SH3_GRAP_C	162..214	CDD:212884	24/51 (47%)
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	31/50 (62%)
		SH2_Grb2_like	56..149	CDD:199828	54/93 (58%)
		SH3_GRB2_like_C	156..208	CDD:212739	25/59 (42%)