Protein Alignment KIF1C and kif1c

DIOPT Version :10

• Sequence 1: NP_006603.2
• Gene: KIF1C / 10749
• HGNCID: 6317
• Length: 1103
• Species: Homo sapiens
• Sequence 2: XP_031755447.1
• Gene: kif1c / 779557
• XenbaseID: XB-GENE-997155
• Length: 1105
• Species: Xenopus tropicalis
• Alignment Length: 1137
• Identity: 800/1137 - (70%)
• Similarity: 892/1137 - (78%)
• Gaps: 66/1137 - (5%)

Human     1 MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSTEDP 65
            ||||||||||||||||:||.:.|||||:.||||||.|.||||.||:.|:|||||||||||:.|||
 Frog     1 MAGASVKVAVRVRPFNSREIAHDAKCVIQMQGNTTCISNPKQPKDSAKNFTFDYSYWSHTTAEDP 65

Human    66 QFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRV 130
            .||||.|||:|||||||||||||||||||||||||:||||||||:.|..|.||:||||||||:||
 Frog    66 NFASQCQVYKDIGEEMLLHAFEGYNVCIFAYGQTGSGKSYTMMGKPESEQHGIIPQLCEDLFARV 130

Human   131 SENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADL 195
            |.|:|..||.||||||||||||||||||||||:|:||||||||:||||:||||||||||.|||||
 Frog   131 SANRSPDLSCSVEVSYMEIYCERVRDLLNPKSKGNLRVREHPIMGPYVEDLSKLAVTSYHDIADL 195

Human   196 MDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGA 260
            ||||||||||||||||||||||||||||||||:.||::|.||:|||||||||||||||||||:||
 Frog   196 MDCGNKARTVAATNMNETSSRSHAVFTIVFTQKRHDEMTNLDTEKVSKISLVDLAGSERADSTGA 260

Human   261 RGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAAL 325
            :|.|||||||||||||||||||||||:||:||:||||||||||.|||||||||||||||||||||
 Frog   261 KGTRLKEGANINKSLTTLGKVISALAEMQNKKKKSDFIPYRDSALTWLLKENLGGNSRTAMIAAL 325

Human   326 SPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGL 390
            |||||||||||||||||||.|||:|||:|||||||||||||:|||||||:||.:|||....::..
 Frog   326 SPADINYEETLSTLRYADRAKQIKCNAVINEDPNARLIRELKEEVARLRQLLYSQGLEDIVIDDS 390

Human   391 KTEEGSVRGALPAVSSPPAP--VSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIAE 453
            .:.......|...||.||.|  ::|.:..|.||:.||.......::|..||||||||||||||||
 Frog   391 ASAPHPPSPAAAPVSPPPLPGSLAPLASPTQNGQSEPFPEGEDAAEICTEEAMERLQETEKIIAE 455

Human   454 LNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHI 518
            ||||||||||||||||.|||||||||||||||||||||||||||.||||||||||||||||||||
 Frog   456 LNETWEEKLRKTEALRTEREALLAEMGVAVREDGGTVGVFSPKKIPHLVNLNEDPLMSECLLYHI 520

Human   519 KDGVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKS 583
            |:|:||||||::||||:||||:||||||.....|.|||:|||||||||||||||||||:.|||||
 Frog   521 KEGITRVGQVEVDIKLSGQFIKEQHCLFHCDTNPSGEVIVTLEPCEGAETYVNGKLVTQALVLKS 585

Human   584 GNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQ 648
            |.||||||||||||||||||||||||....... ||||||||||||||||:||||||||||||||
 Frog   586 GTRIVMGKNHVFRFNHPEQARLERERSSAAIEN-PSEPVDWNFAQKELLEKQGIDIKLEMEKRLQ 649

Human   649 DLENQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGL 713
            |||.||:||||||||.|||||||||||||||||||||||||||||||||::|...||:||:||||
 Frog   650 DLEYQYKKEKEEADLTLEQQRLYADSDSGDDSDKRSCEESWRLISSLREKVPAGRVQSIVRRCGL 714

Human   714 PSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALK 778
            |||||:|.|.||||||||||| ||||||.|:|||||||||||||||||.||:|.|.||||::.:|
 Frog   715 PSSGKKREPIRVYQIPQRRRL-GKDPRWLTLADLKMQAVKEICYEVALNDFKHSRQEIEAMSVIK 778

Human   779 MRELCRTYGKPD-GPGDAWRAVARDVWDTVG-EEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLT 841
            |:||||||||.| ...:.|:||||||||||| .||..|..|..|         |:||:|||||||
 Frog   779 MKELCRTYGKRDINEKELWKAVARDVWDTVGVGEEDAGTKSVSG---------VQDLKAHIDKLT 834

Human   842 GILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENE-EGGEVPWAPPEGSEAAEEAAPS 905
            .|||||||||:.||.|:::|||||::||||:|||||:.||:. :...:||...|..|..|.:. |
 Frog   835 DILQEVKLQNNMKDEEIRSLRDRMIKMERVMPLAQDNGDEDYLDEQSLPWYSNENQEIPEPSG-S 898

Human   906 DRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSG-GRGGGLRRPP--A 967
            ...|...|..|      ||.:||:||..|||||:|||||||.|:|.||... .||   ||.|  .
 Frog   899 GLSPDHSPKEP------RVDQLMDEDATFRRGRMRWLKQEQTRIQNLQQQQINRG---RRLPGTG 954

Human   968 RFVPPHDCKLRFPFKSNPQHRESW-PG-------MGSGEAPTPLQPPEEVTPHPATPARRPPSPR 1024
            ||:||.:||||||||||||||.|| ||       :..| .|:..:..||.:.......:|.....
 Frog   955 RFIPPLECKLRFPFKSNPQHRFSWAPGTTYVVEDLNCG-WPSDSRRGEEESDKRGGRRQRRQGDG 1018

Human  1025 RSHHPRRNSLDGGGRSRGAGSAQP--------EPQHFQPKKHNS--------YPQPP--QPYPAQ 1071
            ..|..||||||||. :||..| ||        |.||.......|        .|.||  :||
 Frog  1019 DYHKQRRNSLDGGS-NRGRRS-QPRQNRQNGEEYQHMGRGGQGSELGGRQQRQPAPPSDRPY--- 1078

Human  1072 RPPGPRYPPYTTPPRMRRQRSAPDLKESGAAV 1103
                 :|.|||.|||||||.|||:|.|:|.||
 Frog  1079 -----KYHPYTAPPRMRRQNSAPELIENGTAV 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	299/350 (85%)
		Kinesin_assoc	352..522	CDD:465047	119/171 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..438		13/39 (33%)
		FHA_KIF1C	498..599	CDD:438780	83/100 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..828		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..924		15/50 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1103		75/181 (41%)
kif1c	XP_031755447.1	KISc_KIF1A_KIF1B	4..355	CDD:276816	299/350 (85%)
		Kinesin_assoc	352..524	CDD:465047	119/171 (70%)
		FHA_KIF1C	500..601	CDD:438780	83/100 (83%)