DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF1C and Klp98A

DIOPT Version :9

Sequence 1:	NP_006603.2	Gene:	KIF1C / 10749	HGNCID:	6317	Length:	1103	Species:	Homo sapiens
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	1134	Identity:	368/1134 - (32%)
Similarity:	519/1134 - (45%)	Gaps:	278/1134 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     4 ASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPK-QS-----KDAPKSFTFDYSYWSHTST 62
            :|:||||||||||:||...||:.::.|:...|.::.|: ||     :|....|||||||||. ..
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSF-DA 65

Human    63 EDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLF 127
            |||.||:|:|||.|:|.:::..|:||||.|:|||||||:||::||||  .|...|::|::||:||
  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128

Human   128 SRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRG-SLRVREHPILGPYVQDLSKLAVTSYAD 191
            :|:...|.:...|....||:|||.|||:|||..:|.| .||||||..|||||::||:.||:.:.:
  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193

Human   192 IADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERAD 256
            |.:.:..||..||.|:||||:|||||||:|||.|.|...  :..:.||.||||.||||||||||:
  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256

Human   257 SSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSD----------------FIPYRDSVL 305
            ::||.|.||||||:|||||.|||.||||||:.......|.                :||||||:|
  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321

Human   306 TWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEV 370
            |||||::|||||:|.|||||||||.||.|||||||||:|.|.|.....:|||.|.:|||||:||:
  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386

Human   371 ARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQI 435
            .:|:.:|                .|.:.                       .|:||.....:.|
  Fly   387 NKLKSML----------------AGDIH-----------------------SLQPSLKVLADLQ- 411

Human   436 GPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPH 500
             .:||.|::         |.|.|.||.:..:::..|:::|      .:|:.|  |||....:.||
  Fly   412 -KKEAQEKV---------LTEEWTEKWKVAQSILQEQKSL------GLRKSG--VGVVLDSEMPH 458

Human   501 LVNLNEDPLMSECLLYHIKDGVTRVGQVD----MDIKLTGQFIREQHCLFRSIPQPDGEVVVTLE 561
            |:.::.| :.:...||.:|:|.||:|..|    .||:|.|..||.|||   ||....|  ||||.
  Fly   459 LIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHC---SIFLKGG--VVTLH 517

Human   562 PCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP-EQARLER------------------ 607
            |...|:.:||..|:.||..:..|:.|::|:.::||||:| |.|:|.:
  Fly   518 PWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSS 582

Human   608 ------------ERGVPPPPGP-----PSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLEN--- 652
                        |.|..|...|     |..|          :.:...:::.|..|.|..:||
  Fly   583 KENLLTCSIYSDEDGASPYKRPERQYYPQRP----------MSRDDPELQDENRKILDTIENALK 637

Human   653 -----------QY------------RKEKEEAD----LLLEQQRLYADSDS---GDDSDKRSCEE 687
                       ||            |.|:||.|    |...:|.|.|..|.   ..:::|...:.
  Fly   638 QLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDI 702

Human   688 SWRLISSLREQLPPTT---VQTIVKR------CG-LPSSGK------------------------ 718
            ..|.||:.:.||....   .:.:.|.      || |...|.
  Fly   703 VCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFA 767

Human   719 --------RRAPRRV----YQIPQRRRLQGKDPRWATMADLKMQAVKEICYEV--ALADFRHGRA 769
                    ||....:    .||.::.|:       ...:..|:..|.|...|:  .|...|..||
  Fly   768 AQFIKDTVRRNNEEIRKLDEQIAEKERI-------LNASTTKIAKVDETMLEIQAQLERLRLERA 825

Human   770 EIEALAALKMRELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVE--- 831
            |.||                  ...|.||..:::...:|.:....:.|...:::.::....|
  Fly   826 ESEA------------------ESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCD 872

Human   832 ---DLRAHIDKLTGIL----QEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVP 889
               ..::::..::...    |:..|.|.|.|.|.:|...|          ..|....:||.....
  Fly   873 TFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTR----------KDDLSGSSEETSRTC 927

Human   890 WAPPEGSEAAEEA--APSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGL 952
            .|.|.....:...  ..|...||..|.|..:.|...|..........:.|.|...||........
  Fly   928 TAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDED 992

Human   953 QGSG-----GRGGGLRRPPARFVPPHDCK 976
            .||.     ||...:.||   :.|.|..:
  Fly   993 TGSCSSCELGRHSDVARP---YCPLHSLR 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	201/373 (54%)
		Kinesin_assoc	352..522	CDD:318424	40/169 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..438		4/37 (11%)
		FHA	499..599	CDD:238017	41/103 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..828		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..924		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	950..1103		8/32 (25%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	201/373 (54%)
		KISc	3..371	CDD:214526	201/372 (54%)
		Kinesin_assoc	370..478	CDD:292801	40/166 (24%)
		FHA	456..555	CDD:238017	41/104 (39%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820