DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF1C and Klp61F

DIOPT Version :9

Sequence 1:	NP_006603.2	Gene:	KIF1C / 10749	HGNCID:	6317	Length:	1103	Species:	Homo sapiens
Sequence 2:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster

Alignment Length:	1186	Identity:	276/1186 - (23%)
Similarity:	469/1186 - (39%)	Gaps:	305/1186 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     5 SVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQ-------SKDAPKSFTFDYSYWSHTST 62
            :::|.|||||.|:||     :|:.|.:  ...::.|::       .....|.||||.|:
  Fly    19 NIQVYVRVRPLNSRE-----RCIRSAE--VVDVVGPREVVTRHTLDSKLTKKFTFDRSF------ 70

Human    63 EDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGR---------QEPGQQGI 118
             .|: :.|..||..:...::.....|||..:|||||||.||::||:|.         ::....||
  Fly    71 -GPE-SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133

Human   119 VPQLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRV-----REHPILGPYV 178
            :|:....||   .|.:..::.|::.:||:|:|.|.:.|||:......:|:     ::..::   :
  Fly   134 IPRALSHLF---DELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVI---I 192

Human   179 QDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSE---K 240
            |.|.::.|.|..|:..|::.|.:.|..|.|.||..|||||.||:||    .|.:..|::.|   |
  Fly   193 QGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIV----VHIRENGIEGEDMLK 253

Human   241 VSKISLVDLAGSERADSSG-ARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSV 304
            :.|::||||||||....:| .:|:|::|..|||:||.|||:||:||.|      ::..:|||:|.
  Fly   254 IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------RAPHVPYRESK 312

Human   305 LTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNAR-LIRELQE 368
            ||.||:|:|||.::|::||.:||...:.|||||||.||.|.|.|:....:|:....: :::|..|
  Fly   313 LTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTE 377

Human   369 EVARLRELLMAQGLSASALEGLKTEE---GSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPN 430
            |:.:|:..|||    |....|:...|   |.:...|               .:.|.||
  Fly   378 EIDKLKRDLMA----ARDKNGIYLAEETYGEITLKL---------------ESQNREL------- 416

Human   431 TESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAV------------ 483
            .|..:..:...:.||..|||.:|::.:..|   ||:.|:...|.||...|..:
  Fly   417 NEKMLLLKALKDELQNKEKIFSEVSMSLVE---KTQELKKTEENLLNTKGTLLLTKKVLTKTKRR 478

Human   484 -REDGGTVGVFSPKKTPHLVNLNEDPLMSECLL-----YHIKDGVTRVGQVDMDIKLTGQFIREQ 542
             :|....|.  |..||..::......:::...|     :.:...:.|..::|..|:
  Fly   479 YKEKKELVA--SHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIR--------- 532

Human   543 HCLFRSIPQPDGEVVVTLEPCEG----------------AETYVNGKLVTEPLVLKSGNRIVMGK 591
                ||..|....:...||...|                ::..||...|::.|.|.|...|.|.|
  Fly   533 ----RSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLK 593

Human   592 NHVFRFNHPEQARLERERGVPPPPGPPSEPVDWN---FAQK--ELLEQQGIDIKLEMEKRLQDLE 651
            ....: :..:|..|..:.     .|...:..|.:   |..|  |.::||.:.:..|::..||.:|
  Fly   594 EMCAQ-SLQDQTNLHNKL-----IGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIE 652

Human   652 NQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTV----------QT 706
            ...::.|...|.:.|:.....      ||..:|.||..:.:....|||...::          :.
  Fly   653 ENNQRHKAMLDSMQEKFATII------DSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEE 711

Human   707 IVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHG---- 767
            :.....|...........:.|:.|.:.|:.|:....::...||:. ..:.....:.|.:.|
  Fly   712 LANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEE-SRLTRNHRIDDIKSGIQDY 775

Human   768 ---------RAEIEALAALKMRELCRTYGKPDGPGDAWRAVA---------RDVWDTVGEEEGGG 814
                     .|:.|..:.::...||...|           ||         :::.....:|....
  Fly   776 QKLGIEASQSAQAELTSQMEAGMLCLDQG-----------VANCSMLQVHMKNLNQKYEKETNEN 829

Human   815 AGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRM-LRMERVIPLAQDH 878
            .||               :|.|.:::..|.||.|       ::|:|::::. :.:|:::
  Fly   830 VGS---------------VRVHHNQVEIICQESK-------QQLEAVQEKTEVNLEQMV------ 866

Human   879 EDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLK 943
                              :|.::....||.......:......:..:|...|....:|.:|:..:
  Fly   867 ------------------DARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICE 913

Human   944 QEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRE---------SWPGM----- 994
            ||.:|.|..:.......|.......||.|.......|      |:|         .|..:
  Fly   914 QELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSP------HQEIVRRYRQELDWSDLDTTAT 972

Human   995 ----GSGE------------------APTPLQPPEEVT-----------------PHPATPARRP 1020
                ..||                  ..||::|.:.||                 |..||..:|.
  Fly   973 IDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRS 1037

Human  1021 PSPRRSHHPRRNSLDG 1036
            .|..||..|.:.|..|
  Fly  1038 SSLSRSLTPSKTSPRG 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	133/374 (36%)
		Kinesin_assoc	352..522	CDD:318424	37/191 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..438		5/37 (14%)
		FHA	499..599	CDD:238017	19/120 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..828		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..924		3/49 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	950..1103		26/140 (19%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	134/376 (36%)
		Kinesin	25..356	CDD:278646	130/361 (36%)
		Microtub_bind	923..>1009	CDD:290642	13/91 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910