Protein Alignment KIF1C and unc-104

DIOPT Version :10

• Sequence 1: NP_006603.2
• Gene: KIF1C / 10749
• HGNCID: 6317
• Length: 1103
• Species: Homo sapiens
• Sequence 2: NP_001022041.2
• Gene: unc-104 / 174144
• WormBaseID: WBGene00006831
• Length: 1628
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 398/752 - (52%)
• Similarity: 519/752 - (69%)
• Gaps: 69/752 - (9%)

Human     4 ASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSTEDPQFA 68
            :||||||||||||.||.|..:|||:.:.||||:|.....:|: ..||.||:||||. :..||.|.
 Worm     2 SSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKE-NFSFNFDHSYWSF-ARNDPHFI 64

Human    69 SQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGR-QEPGQQGIVPQLCEDLFSRVSE 132
            :|:|||.::|.|||.|||||||||||||||||:||||||||: .:|.:.||:|:||.|||:|:..
 Worm    65 TQKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFARIDN 129

Human   133 NQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMD 197
            |....:.|||||||||||||||:|||||.|.|:|||||||:|||||.||:|:||.||.||.:|||
 Worm   130 NNDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVDDLTKMAVCSYHDICNLMD 194

Human   198 CGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGARG 262
            .|||||||||||||.||||||||||||.||:.|...:.||:||.||||||||||||||:|:||.|
 Worm   195 EGNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEKHSKISLVDLAGSERANSTGAEG 259

Human   263 MRLKEGANINKSLTTLGKVISALADMQSKKRKSD--FIPYRDSVLTWLLKENLGGNSRTAMIAAL 325
            .||||||||||||||||.|||.||:..:||:||:  .||||||||||||:|||||||:|||:|||
 Worm   260 QRLKEGANINKSLTTLGLVISKLAEESTKKKKSNKGVIPYRDSVLTWLLRENLGGNSKTAMLAAL 324

Human   326 SPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGL 390
            ||||||::|||||||||||.|||.|.|::||||||:|||||.|||.:||.:|..:|:..:.::
 Worm   325 SPADINFDETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKDKGIDVTDVQ-- 387

Human   391 KTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIAELN 455
                                   .:|..|..      .|...:.:  .|.:|:|||:||::||:.
 Worm   388 -----------------------ETPGKHKK------GPKLPAHV--HEQLEKLQESEKLMAEIG 421

Human   456 ETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKD 520
            :|||:||..||.:|.:||..|.:||:|..|||.|:|||||||.||||||||||||||||:|::|:
 Worm   422 KTWEQKLIHTEEIRKQREEELRDMGLACAEDGTTLGVFSPKKLPHLVNLNEDPLMSECLIYYLKE 486

Human   521 GVTRVGQVDM----DIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVL 581
            |||.||:.:.    ||.|:|:.|.|.||.|.:   .||.|.:|::|  .|..|:|||.||.|.||
 Worm   487 GVTSVGRPEAEHRPDILLSGEAILELHCEFIN---EDGNVTLTMKP--NASCYINGKQVTTPTVL 546

Human   582 KSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKR 646
            .:|:|:::|::||||:|.|::||..|..    ......:|:||.:||:|||::||||:|.:|||:
 Worm   547 HTGSRVILGEHHVFRYNDPQEARQSRHN----LAAIAEQPIDWKYAQQELLDKQGIDLKADMEKK 607

Human   647 LQDLENQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRC 711
            :.::|:|||:||.|.     :|::|           ....|...:|.:|::|:  ...|:.:...
 Worm   608 MLEMESQYRREKVEL-----EQKMY-----------HQTREYESMIENLQKQV--DLAQSYISGG 654

Human   712 GLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLK 748
            |....|:|.....:.:.|:..:......|....|.:|
 Worm   655 GSIWEGERMLTSSLLEFPEELKWTSDQKRVVLKAAIK 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	247/353 (70%)
		Kinesin_assoc	352..522	CDD:465047	74/169 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..438		3/37 (8%)
		FHA_KIF1C	498..599	CDD:438780	54/104 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..828
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..924
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1103
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	247/353 (70%)
		Kinesin_assoc	351..488	CDD:465047	74/169 (44%)
		FHA_KIF1	464..564	CDD:438757	54/104 (52%)
		Rcc_KIF21	595..652	CDD:425381	22/74 (30%)
		KIF1B	829..875	CDD:463574
		DUF3694	1116..1260	CDD:463599
		PH_KIFIA_KIFIB	1500..1602	CDD:269939