DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MASP2 and CG11836

DIOPT Version :9

Sequence 1:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens
Sequence 2:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster

Alignment Length:	268	Identity:	96/268 - (35%)
Similarity:	136/268 - (50%)	Gaps:	35/268 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   426 SLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLIL--GGTTAAGALLYDNWVLTAAHAVYEQ 488
            ||..|:..||.|....  ||.||:......:||...|:  |.....|:||..::||:|||.|  :
  Fly    80 SLKNCDCDCGFSNEEI--RIVGGKPTGVNQYPWMARIVYDGKFHCGGSLLTKDYVLSAAHCV--K 140

Human   489 KHDASALDIRMGTLKRLSPHYTQAWSE---------AVFIHEGYTHDAGFDNDIALIKLNNKVVI 544
            |...|.:.:..|      .|..:..||         ||..|:.:..|. ::|||||::|...:..
  Fly   141 KLRKSKIRVIFG------DHDQEITSESQAIQRAVTAVIKHKSFDPDT-YNNDIALLRLRKPISF 198

Human   545 NSNITPICLPRKEAESFMRTDDIGTASGWGLT-QRGFLARNLMYVDIPIVDHQKCTAAYEKPPYP 608
            :..|.||||||...:...|   |||..|||.| :.|.|...:..|.:||:...:|    ....|.
  Fly   199 SKIIKPICLPRYNYDPAGR---IGTVVGWGRTSEGGELPSIVNQVKVPIMSITEC----RNQRYK 256

Human   609 RGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVI 673
            ...:|::|||||..|  .|||:|||||.|:.  |...::|:.|||||| :.||..|..|||::|.
  Fly   257 STRITSSMLCAGRPS--MDSCQGDSGGPLLL--SNGVKYFIVGIVSWG-VGCGREGYPGVYSRVS 316

Human   674 NYIPWIEN 681
            .:||||::
  Fly   317 KFIPWIKS 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478
		Sushi	366..430	CDD:278512	2/3 (67%)
		Tryp_SPc	444..679	CDD:214473	88/246 (36%)
		Tryp_SPc	445..682	CDD:238113	89/249 (36%)
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	89/249 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910