DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K2 and STE11

DIOPT Version :9

Sequence 1:	NP_001358839.1	Gene:	MAP3K2 / 10746	HGNCID:	6854	Length:	619	Species:	Homo sapiens
Sequence 2:	NP_013466.1	Gene:	STE11 / 851076	SGDID:	S000004354	Length:	717	Species:	Saccharomyces cerevisiae

Alignment Length:	612	Identity:	180/612 - (29%)
Similarity:	257/612 - (41%)	Gaps:	180/612 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    87 NELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKR 151
            |.|:.....|...|||:. ..:.:::::|..|..:..|  ::||  |...:.:.:.  .||.|.|
Yeast   205 NRLIFVSKDQTPSDKAIS-TSKKLYLRTLSALSQVGPS--SSNL--LAQNKGISHN--NAEGKLR 262

Human   152 LSIIGPTSRDR-----SSPPP---------GYIP--------DELHQVARNGSFTSI-------- 186
               |..|.:||     :..||         ||.|        ..:.:..|:.:..||
Yeast   263 ---IDNTEKDRIRQIFNQRPPSEFISTNLAGYFPHTDMKRLQKTMRESFRHSARLSIAQRRPLSA 324

Human   187 --NSEGEFI---PESMD----QMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPD 242
              |:.|:.:   ..::|    |.||...||              |.||....||
Yeast   325 ESNNIGDILLKHSNAVDMALLQGLDQTRLS--------------SKLDTTKIPK----------- 364

Human   243 NHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHS 307
                                       :::...|.||                    :.|.....
Yeast   365 ---------------------------LAHKRPEDND--------------------AISNQLEL 382

Human   308 LSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYL 372
            ||..||      |.:|.......|||         :|.|::. ..|.||..|..:|.|:||.|||
Yeast   383 LSVESG------EEEDHDFFGEDSDI---------VSLPTKI-ATPKNWLKGACIGSGSFGSVYL 431

Human   373 CYDVDTGRELAVKQVQFDPDS----------------------------------PETS-----K 398
            ..:..||..:|||||:...::                                  |:|:     |
Yeast   432 GMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRK 496

Human   399 EVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKY 463
            .|:||:.|:.|||.|.||.||.|||.  ..:...|:||:||:||||:...|..||...|::...:
Yeast   497 MVDALQHEMNLLKELHHENIVTYYGA--SQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNF 559

Human   464 TRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWM 528
            |||||.||.|||...|:||||||||||.|..|.||:.|||.||:|..:........|:.|:.:||
Yeast   560 TRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWM 624

Human   529 SPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF 593
            ||||:.......||||||..|.|:||.|.|.|:.:|..|.|||||.|. |.|::|...:...::|
Yeast   625 SPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIGTN-TTPEIPSWATSEGKNF 688

Human   594 LKRIF-VEAKLRPSADELLRHMFVHYH 619
            |::.| ::.:.||||.|||:|.::..|
Yeast   689 LRKAFELDYQYRPSALELLQHPWLDAH 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K2	NP_001358839.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..45
		PB1_Mekk2_3	44..122	CDD:99726	8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..173		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..248		9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..355		13/65 (20%)
		STKc_MEKK2	353..616	CDD:270818	123/302 (41%)
STE11	NP_013466.1	SAM_Ste11_fungal	20..82	CDD:188933
		Ras_bdg_2	121..224	CDD:405528	6/19 (32%)
		PKc_like	415..712	CDD:419665	121/299 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I635
eggNOG	1	0.900	-	-		E1_KOG0198
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001353
OrthoInspector	1	1.000	-	-		otm53196
orthoMCL	1	0.900	-	-		OOG6_100581
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X764
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.710