DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K2 and Map3k2

DIOPT Version :9

Sequence 1:	NP_001358839.1	Gene:	MAP3K2 / 10746	HGNCID:	6854	Length:	619	Species:	Homo sapiens
Sequence 2:	NP_036076.2	Gene:	Map3k2 / 26405	MGIID:	1346873	Length:	619	Species:	Mus musculus

Alignment Length:	619	Identity:	596/619 - (96%)
Similarity:	609/619 - (98%)	Gaps:	0/619 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKL 65
            ||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||..|||||
Mouse     1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVKL 65

Human    66 EDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNL 130
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
Mouse    66 EDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVVNGSTQATNL 130

Human   131 EPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPE 195
            ||.||.|||:||..|||||||||::||.:|||||||||||||||||:||||||||||||||||||
Mouse   131 EPSPSPEDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPE 195

Human   196 SMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGK 260
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
Mouse   196 SMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFTDYDNPIFEKFGK 260

Human   261 GGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSR 325
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||:|||||||||
Mouse   261 GGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSVFTPEYDDSR 325

Human   326 IRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFD 390
            |||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   326 IRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFN 390

Human   391 PDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGAL 455
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 PESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGAL 455

Human   456 TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKS 520
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   456 TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKS 520

Human   521 VTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 VTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH 585

Human   586 VSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH 619
            ||||||||||||||||||||||:|||||||||||
Mouse   586 VSDYTRDFLKRIFVEAKLRPSAEELLRHMFVHYH 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K2	NP_001358839.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..45		18/19 (95%)
		PB1_Mekk2_3	44..122	CDD:99726	74/77 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..173		14/18 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..248		46/46 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..355		62/65 (95%)
		STKc_MEKK2	353..616	CDD:270818	258/262 (98%)
Map3k2	NP_036076.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44		17/18 (94%)
		PB1_Mekk2_3	44..122	CDD:99726	74/77 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..168		32/41 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..247		45/45 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..355		62/65 (95%)
		STKc_MEKK2	353..616	CDD:270818	258/262 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83958782
Domainoid	1	1.000	516	1.000	Domainoid score	I7118
eggNOG	1	0.900	-	-		E1_KOG0198
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74576
Inparanoid	1	1.050	1208	1.000	Inparanoid score	I4322
Isobase	1	0.950	-	0	Normalized mean entropy	S2877
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43375
OrthoDB	1	1.010	-	-		D126545at7742
OrthoFinder	1	1.000	-	-		FOG0001353
OrthoInspector	1	1.000	-	-		oto121207
orthoMCL	1	0.900	-	-		OOG6_100581
Panther	1	1.100	-	-	LDO	PTHR24361
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2061
SonicParanoid	1	1.000	-	-		X764
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	20	20.250