DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K2 and byr2

DIOPT Version :9

Sequence 1:	NP_001358839.1	Gene:	MAP3K2 / 10746	HGNCID:	6854	Length:	619	Species:	Homo sapiens
Sequence 2:	NP_595714.2	Gene:	byr2 / 2540612	PomBaseID:	SPBC1D7.05	Length:	659	Species:	Schizosaccharomyces pombe

Alignment Length:	690	Identity:	194/690 - (28%)
Similarity:	287/690 - (41%)	Gaps:	175/690 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    25 LSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNEL 89
            |.::.|.|.|..  .||.|.           :.:||||..|..:....:....||...:.....:
pombe    46 LGIENTAKGKQF--LKQRDY-----------LREFPRPCILRFIACNGQTRAVQSRGDYQKTLAI 97

Human    90 VIPLTTQDDLDKAVELLDRSIHMK-----SLKILLVINGSTQATNL------EPLPSLEDLDNT- 142
            .:...:.:|..|.:..:.:|..:|     ..|.:...:.|.:...|      :|.||.|||..:
pombe    98 ALKKFSLEDASKFIVCVSQSSRIKLITEEEFKQICFNSSSPERDRLIIVPKEKPCPSFEDLRRSW 162

Human   143 ----------VFGAERKKRLSIIGPTSRDRSS-------PPPGY--IPDELHQVARNGSFTSINS 188
                      ...:....:||.:.|||..:.|       |...|  .|.||           |||
pombe   163 EIELAQPAALSSQSSLSPKLSSVLPTSTQKRSVRSNNAKPFESYQRPPSEL-----------INS 216

Human   189 E-GEFIPESMDQMLDP---------LSLSSPENSGSGS-------------------CP------ 218
            . .:|.|:...::|:.         ||:.:.:....|:                   ||
pombe   217 RISDFFPDHQPKLLEKTISNSLRRNLSIRTSQGHNLGNFGQEILPRSSRRARPSELVCPLSSLRI 281

Human   219 --------------SLDSPLDGESYPK-SRMPRAQS----------YPDNHQEFSDYDNPIFEKF 258
                          ..|.||...|..: ||.|..|.          |..|..|.|...| :|.:.
pombe   282 SVAEDVNRLPRIDRGFDPPLTVSSTQRISRPPSLQKSITMVGVEPLYQSNGNEKSSKYN-VFSES 345

Human   259 GKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDD 323
            ..|           :||..:....:.|       :.:..|...|||.   :||..::....:.||
pombe   346 AHG-----------NHQVLSFSPGSSP-------SFIEQPSPISPTS---TTSEDTNTLEEDTDD 389

Human   324 SRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQ 388
            ..|:                            |..|.|:|.|:||:|||..:..:|..:|||||.
pombe   390 QSIK----------------------------WIRGALIGSGSFGQVYLGMNASSGELMAVKQVI 426

Human   389 FDPDSPET---SKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLK 450
            .|..|...   :|.::||..||.||:.|.||.||||.|  .:.....|:||:||:||||:...|.
pombe   427 LDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLG--SNLNSDHLNIFLEYVPGGSVAGLLT 489

Human   451 AYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQ---TIC 512
            .||:..|.:.:.:.:|.|:|:.||||..||||||||||||.|:.|.:|:.|||.||:|:   |..
pombe   490 MYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTST 554

Human   513 LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQP 577
            .:|....|..|:.:||:|||:....:..|.||||:.|.|:||||.|.|:...:.|.|||:|. :.
pombe   555 KTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIG-EN 618

Human   578 TNPKLPPHVSDYTRDFLKRIF-VEAKLRPSADELLRHMFV 616
            ..|:.|.::|....|||::.| ::..|||:|.|||.|.||
pombe   619 ILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFV 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K2	NP_001358839.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..45		7/19 (37%)
		PB1_Mekk2_3	44..122	CDD:99726	12/82 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..173		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..248		17/105 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..355		9/65 (14%)
		STKc_MEKK2	353..616	CDD:270818	116/269 (43%)
byr2	NP_595714.2	PKc_like	393..658	CDD:304357	116/295 (39%)
byr2	NP_595714.2	Pkinase	394..658	CDD:278497	116/266 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	210	1.000	Domainoid score	I697
eggNOG	1	0.900	-	-		E1_KOG0198
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001353
OrthoInspector	1	1.000	-	-		mtm10309
orthoMCL	1	0.900	-	-		OOG6_100581
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X764
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.670