Protein Alignment MAP3K2 and Map3k2

DIOPT Version :9

• Sequence 1: NP_001358839.1
• Gene: MAP3K2 / 10746
• HGNCID: 6854
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_612512.1
• Gene: Map3k2 / 171492
• RGDID: 620967
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 595/619 - (96%)
• Similarity: 608/619 - (98%)
• Gaps: 0/619 - (0%)

Human     1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKL 65
            ||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||..|||||
  Rat     1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVKL 65

Human    66 EDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNL 130
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat    66 EDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVLNGSTQATNL 130

Human   131 EPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPE 195
            ||.||.:||:||..|||||||||::||.:|||||||||||||||||:||||||||||||||||||
  Rat   131 EPSPSPDDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPE 195

Human   196 SMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 SMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGK 260

Human   261 GGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSR 325
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||:|||
  Rat   261 GGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYEDSR 325

Human   326 IRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFD 390
            |||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   326 IRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFN 390

Human   391 PDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGAL 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 PDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGAL 455

Human   456 TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKS 520
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
  Rat   456 TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKS 520

Human   521 VTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 VTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH 585

Human   586 VSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH 619
            ||||||||||||||||||||||:|||||:|||.|
  Rat   586 VSDYTRDFLKRIFVEAKLRPSAEELLRHLFVHCH 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K2	NP_001358839.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..45		18/19 (95%)
		PB1_Mekk2_3	44..122	CDD:99726	74/77 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..173		14/18 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..248		46/46 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..355		62/65 (95%)
		STKc_MEKK2	353..616	CDD:270818	258/262 (98%)
Map3k2	NP_612512.1	PB1_Mekk2_3	44..122	CDD:99726	74/77 (96%)
		STKc_MEKK2	353..616	CDD:270818	258/262 (98%)
		S_TKc	356..616	CDD:214567	255/259 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83682918
Domainoid	1	1.000	522	1.000	Domainoid score	I6525
eggNOG	1	0.900	-	-		E1_KOG0198
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74576
Inparanoid	1	1.050	1212	1.000	Inparanoid score	I4013
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43375
OrthoDB	1	1.010	-	-		D126545at7742
OrthoFinder	1	1.000	-	-		FOG0001353
OrthoInspector	1	1.000	-	-		oto137455
orthoMCL	1	0.900	-	-		OOG6_100581
Panther	1	1.100	-	-	LDO	PTHR24361
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X764
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270