Protein Alignment MAP3K2 and map3k2

DIOPT Version :10

• Sequence 1: NP_006600.3
• Gene: MAP3K2 / 10746
• HGNCID: 6854
• Length: 619
• Species: Homo sapiens
• Sequence 2: XP_002942055.2
• Gene: map3k2 / 100493570
• XenbaseID: XB-GENE-969986
• Length: 630
• Species: Xenopus tropicalis
• Alignment Length: 623
• Identity: 542/623 - (86%)
• Similarity: 575/623 - (92%)
• Gaps: 6/623 - (0%)

Human     1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKL 65
            ||:|||||||||||.||||||||||||..  ...|.|||||||||||||||||||||||.|||.|
 Frog    10 MDEQQALNSIMQDLVVLHKASRPALSLHV--PGSSKSPKKQNDVRVKFEHRGEKRILQFSRPVLL 72

Human    66 EDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNL 130
            |||.:|||:||||.|||||:||||||||.|||||||||||||||:||||||||||:.|.|:...|
 Frog    73 EDLYAKAKVAFGQCMDLHYSNNELVIPLKTQDDLDKAVELLDRSVHMKSLKILLVLPGHTETDTL 137

Human   131 ---EPLPSLEDLDNTVFGA-ERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGE 191
               |.:||||||||:||.. ::|.:.|.||..:||||||||||||::||||.|||||||||||||
 Frog   138 CDMEHMPSLEDLDNSVFATLDKKTKTSGIGAQTRDRSSPPPGYIPEDLHQVVRNGSFTSINSEGE 202

Human   192 FIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFE 256
            |||||||||||||||||||||||||||||||||||:||.|||||||||||||:|||.:||.|:||
 Frog   203 FIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGDSYSKSRMPRAQSYPDNYQEFLEYDIPVFE 267

Human   257 KFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEY 321
            |||||||||||||||||||:||||||||||||||||.|.||||:|||||||||||||||:|||||
 Frog   268 KFGKGGTYPRRYHVSYHHQDYNDGRKTFPRARRTQGNSFRSPVNFSPTDHSLSTSSGSSVFTPEY 332

Human   322 DDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQ 386
            :|.|:||||||||||||:||||||||||||||:|||||||||||||||||||||.||||||||||
 Frog   333 EDGRLRRRGSDIDNPTLSVMDISPPSRSPRAPSNWRLGKLLGQGAFGRVYLCYDADTGRELAVKQ 397

Human   387 VQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA 451
            |||||||.|||||||||||||||||||||||||||||||||.|||||||||||||||||||||||
 Frog   398 VQFDPDSLETSKEVNALECEIQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKA 462

Human   452 YGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGT 516
            ||||||.|||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
 Frog   463 YGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGT 527

Human   517 GMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPK 581
            |||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||:
 Frog   528 GMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQ 592

Human   582 LPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH 619
            ||.|||::.||||||||||||:|||::|||||.|..||
 Frog   593 LPAHVSEHCRDFLKRIFVEAKVRPSSEELLRHTFAQYH 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K2	NP_006600.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..45		11/19 (58%)
		PB1_Mekk2_3	44..122	CDD:99726	68/77 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..173		14/18 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..248		43/46 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..355		57/65 (88%)
		STKc_MEKK2	353..616	CDD:270818	246/262 (94%)
map3k2	XP_002942055.2	PB1_Mekk2_3	51..129	CDD:99726	68/77 (88%)
		STKc_MEKK2	364..627	CDD:270818	246/262 (94%)