Protein Alignment STAG3 and stag1a

DIOPT Version :10

• Sequence 1: XP_016867173.2
• Gene: STAG3 / 10734
• HGNCID: 11356
• Length: 1242
• Species: Homo sapiens
• Sequence 2: NP_001349269.1
• Gene: stag1a / 564533
• ZFINID: ZDB-GENE-070912-448
• Length: 1258
• Species: Danio rerio
• Alignment Length: 1255
• Identity: 601/1255 - (47%)
• Similarity: 826/1255 - (65%)
• Gaps: 89/1255 - (7%)

Human    38 EGNGDSLLADEDT--------DFEDSLNRNVKKR--------AAKRPPKTTPVAKHPKKGSRVVH 86
            :..|||   .:||        :.:|..:..:||:        ||.:.|:.:|    .:||...|.
Zfish    10 QDTGDS---GQDTVSLSMSMSELDDPGDGKIKKKRGRPGRPPAANKKPRKSP----SEKGFMAVQ 67

Human    87 RH------SRKQSEPPANDLFNAVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCGCKG 145
            |.      |::..|.....||..||..||.|||:||:|::|||||:|...|:|:|||||..||||
Zfish    68 RGRKANGISQQNGEGDPVTLFEVVKQGKSAMQSVVDDWIESYKQDRDLALLDLINFFIQCSGCKG 132

Human   146 IVTPEMFKKMSNSEIIQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLLYDG 210
            .|..|||:.|.|:|||:.:||:|:||||||||...||.||||:.:||||:..|:.|||||::||.
Zfish   133 TVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTISGPLWKKFRYNFCEFICVLIRQCQYSIIYDE 197

Human   211 FPMDDLISLLTGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQR 275
            :.||.:||||||||||||||||||||||||||||:||.|||.||::|||.||||||||:|..|:|
Zfish   198 YMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINQDNTQRQYEAERSKIVGKR 262

Human   276 APERLESLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYSTSFL 340
            |.|:||.||:|||||||:|:|||.|||::|:|:|||||||.:.|||||||||||.||:.||.:||
Zfish   263 ATEKLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFL 327

Human   341 TDSYLKYIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDVAVE 405
            .||||||:||||||:..||||||:|||:.||.||:|..:|||||:|||||:|||.:|:|||||||
Zfish   328 NDSYLKYVGWTLHDRQGEVRLKCLKALQNLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVE 392

Human   406 AVRLLILILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYWKLFY---PECEIRMMGGREQ 467
            |:||:.|||:..|..|::.|||:||.:||::||.:|.||||||:.|||.   |:.| ..:..|..
Zfish   393 AIRLVTLILQGSEDALSNEDCENVYHLVYSAHRPVAVAAGEFLHRKLFSRHDPQAE-EALAKRRG 456

Human   468 RQSPGAQRTFFQLLLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLTSLLLEK----DQNLGD 528
            |.||..  ...::|:.||:|||||:||||||||||:.:...|||||.:|.||||:    ::.|.|
Zfish   457 RSSPNG--NLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEVLAD 519

Human   529 VQESTLIEILVSSARQASEGHPPVGRVTGRKGLTSKERKTQADDRVKLTEHLIPLLPQLLAKFSA 593
            .|||:|||:.|.:.|||:|.||||||.||::.||:||||.|.||:.|||||.|..||.||:|:..
Zfish   520 RQESSLIELTVCTIRQAAEAHPPVGRGTGKRVLTAKERKMQIDDKNKLTEHFIMALPMLLSKYQT 584

Human   594 DAEKVTPLLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKHAEPAVLEAGAHALYLLCNPEFT 658
            |:|||..|||:...|||.:|..||:||||:..|:|::.||.||.:..||||.:....:||:.|:|
Zfish   585 DSEKVANLLQIPQYFDLDVYSAGRMEKHLDALLKQIKFVVEKHTDTEVLEACSKTYSILCSEEYT 649

Human   659 FFSRADFARSQLVDLLTDRFQQELEELLQS-SFLDEDEVYNLAATLKRLSAFYNTHDLTRWELYE 722
            ..:|.|.|||||:|.|.|||...:|||||: ...|:|::||:.:|||||:||:|.||||||:.:.
Zfish   650 IMNRVDIARSQLIDELADRFNHSVEELLQAGEEADDDDIYNVLSTLKRLTAFHNAHDLTRWDFFG 714

Human   723 PCCQLLQKAVDTGEVPHQVILPALTLVYFSILWTLTHISKSDASQKQLSSLRDRMVAFCELCQSC 787
            .|.:||:..::.|.:|.|:.:.||...::||||.|..|::...|:..|.:||..:.:|..:||.|
Zfish   715 NCYRLLRTGIEQGSMPEQIAVQALQCSHYSILWQLVKITEGAPSKDDLLALRRVVKSFLAICQQC 779

Human   788 LSDVDTEIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSELASFLMDHVFIQPGDL 852
            ||:|:|.::||||:||.|||:|||.|:..|.|:.|:||||.|:.|||:||.:|::|||||...|.
Zfish   780 LSNVNTPVKEQAFMLLCDLLMIFSHQLTTGSREGLQPLVFIPDGTLQNELLNFILDHVFIDQDDE 844

Human   853 G---SGDSQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNKFYNDYGDIIKETLT 914
            .   .||.:::..:||.||:||.|||.|.||::|.:::|.||:|:||||.|:||||||||||||:
Zfish   845 NQSIEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIIDMPAAADIFKHYMKYYNDYGDIIKETLS 909

Human   915 RARQIDRSHCSRILLLSLKQLYTELLQEHGPQGLNELPAFIE-MRDLARRFALSFGPQQLQNRDL 978
            :.||.|:..|::.|:|||:||:.||:|:.|| .|:...:.:. :::|||||||:||..|::.|:.
Zfish   910 KTRQTDKILCAKTLILSLQQLFNELIQDQGP-NLDRTSSHVSGIKELARRFALTFGLDQIKTREA 973

Human   979 VVMLHKEGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLSYLEKCL-QHVSQAP 1042
            |..|||:||:|:.....|.|:...||||||||:|.|||.:|..|||:.:.:||||.: :.:.:..
Zfish   974 VATLHKDGIEFAFKYQNPKGAEYPPPNLAFLEVLCEFSSKLLRQDKKTVHAYLEKFMTEQMMERR 1038

Human  1043 GHPWGPVTTYCHSL------SPVENTAETSPQVLPSSKRRRVEGPAKPNREDVSSSQ------EE 1095
            ...|.|:.:|.:||      ..:..|:.:|.....|.:.::...|....|.:..|.:      .:
Zfish  1039 EDIWLPLISYRNSLLTGGDEDRMSITSGSSSSKAGSIRSKKGRPPLHKKRIEEESMEGSWMMRND 1103

Human  1096 SLQLNSIPPTPTLTSTAVKS--RQPLWGLKEMEEEDGSELDFAQ---------GSQPVAGTERSR 1149
            |:|......||.||||.::.  ||....|.|.:.|.|||.|:..         |.|.:....|..
Zfish  1104 SIQTPGGLQTPQLTSTVLRENPRQAAEHLPEQDTEPGSESDYVHNPQMQMSWLGQQKMEEVNRKE 1168

Human  1150 FLGPQYFQTPHNPSGPGLGNQLMRLSLMEEDEEEELE---------IQDESNEERQDT---DMQA 1202
            .....|.:     :..|...|.:| .|||:|.|...|         ::|.| ||.:||   |:..
Zfish  1169 RTAMSYIK-----ARSGGVRQTVR-GLMEDDAEPIFEDVMMSSRGQLEDMS-EEFEDTMVIDLPP 1226

Human  1203 S-SYSSTSERGLDLLDSTEL 1221
            | :....:|...|..||..:
Zfish  1227 SRNRRERAELRPDFFDSAAM 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAG3	XP_016867173.2	IRR1	37..>394	CDD:227824	219/377 (58%)
		STAG	173..286	CDD:462502	80/112 (71%)
stag1a	NP_001349269.1	IRR1	105..>398	CDD:227824	203/292 (70%)
		STAG	160..273	CDD:462502	80/112 (71%)