DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STAG3 and stag1b

DIOPT Version :9

Sequence 1:	XP_016867172.1	Gene:	STAG3 / 10734	HGNCID:	11356	Length:	1239	Species:	Homo sapiens
Sequence 2:	XP_692120.3	Gene:	stag1b / 563669	ZFINID:	ZDB-GENE-030131-1393	Length:	1256	Species:	Danio rerio

Alignment Length:	1267	Identity:	613/1267 - (48%)
Similarity:	854/1267 - (67%)	Gaps:	84/1267 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    31 RDSNHTSEGNGDSL-LADEDTDFED-SLNRNVKKR-------AAKRPPKTTPVAKHPKKGSRVVH 86
            :||  :::|.||:: ||...::.:| .:.:..|||       ||.:..:.:||.|..::.:.|.|
Zfish    10 QDS--SNDGQGDTISLAMSVSELDDPEVGKGKKKRGRPGKQGAANKKARRSPVDKGGRRPNGVAH 72

Human    87 RHSRKQSEPPANDLFNAVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCGCKGIVTPEM 151
            ::. :.::|  :.||..||..||.|||::|:|::|||||:|...|:|:||||...||||.|..||
Zfish    73 QNG-EGTDP--STLFEVVKQGKSAMQSVIDDWIESYKQDRDLALLDLINFFIHCSGCKGTVRIEM 134

Human   152 FKKMSNSEIIQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLLYDGFPMDDL 216
            |:.|.|:|||:.:||:|:||||||||...||.||||:.:||||:..|:.|||||::||.:.||.:
Zfish   135 FRNMQNAEIIRKMTEEFDEDSGDYPLTMTGPQWKKFRYNFCEFIMVLIRQCQYSIIYDEYMMDTV 199

Human   217 ISLLTGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQRAPERLE 281
            ||||||||||||||||||||||||||||:||.|||.||::|||.||||||||||..|:||.|:||
Zfish   200 ISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINQDNTQRQYEAERNKVAGKRANEKLE 264

Human   282 SLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYSTSFLTDSYLK 346
            .||||||||||:|:|||.|||::|:|:|||||||.:.|||||||||||.||:.||.:||.|||||
Zfish   265 LLLEKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKLYSDAFLNDSYLK 329

Human   347 YIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDVAVEAVRLLI 411
            |:||||||:..||||||:|||:.||.||:|..:|||||:|||||:|||.:|:||||||||:||:.
Zfish   330 YVGWTLHDRQGEVRLKCLKALQTLYTNRELYPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVT 394

Human   412 LILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYWKLFY---PECEIRMMGGREQRQSPGA 473
            |||...|..|::.|||:||.:||::||.:|.||||||:.|||.   |:.| ..:..|..|.||..
Zfish   395 LILHGSEDALSNEDCENVYHLVYSAHRPVAVAAGEFLHRKLFSRHDPQAE-EALAKRRGRNSPNG 458

Human   474 QRTFFQLLLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLTSLLLEK----DQNLGDVQESTL 534
              ...::|:.||:|||||:|||||||||||.:...||||:.:..||||.    ::.|||..||.|
Zfish   459 --NLIKMLVLFFLESELHEHAAYLVDSLWDSSHDLLKDWDCMVELLLEDPVQGEEVLGDRHESAL 521

Human   535 IEILVSSARQASEGHPPVGRVTGRKGLTSKERKTQADDRVKLTEHLIPLLPQLLAKFSADAEKVT 599
            ||::|.:.|||:|.||||||.||::.||:||:|||.||:.:||||||..||.||:|:..|||||.
Zfish   522 IELMVCTIRQAAEAHPPVGRGTGKRVLTAKEKKTQIDDKNRLTEHLIVALPMLLSKYQVDAEKVA 586

Human   600 PLLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKHAEPAVLEAGAHALYLLCNPEFTFFSRAD 664
            .|||:...|||.:|.:||:||||:..|:|::.||.||||..||||.:....:||:.|:|..:|.|
Zfish   587 NLLQIPQYFDLEVYSSGRMEKHLDALLKQIRVVVEKHAEMEVLEACSKTYSILCSEEYTIMNRVD 651

Human   665 FARSQLVDLLTDRFQQELEELLQ-SSFLDEDEVYNLAATLKRLSAFYNTHDLTRWELYEPCCQLL 728
            .|||||:|.|||:|...:|:||| ....|:|::||:.:|||:|:||:|.||||:|:|::.|.:||
Zfish   652 IARSQLIDELTDKFAHSVEDLLQEGEEADDDDIYNVLSTLKKLTAFHNAHDLTKWDLFKNCYRLL 716

Human   729 QKAVDTGEVPHQVILPALTLVYFSILWTLTHISKSDASQKQLSSLRDRMVAFCELCQSCLSDVDT 793
            :..::.|.:|.|:.:.||...::||||.|..|::...|:..|.:||..:.:|..:||.|||:|:|
Zfish   717 KMGIEQGSMPEQIAVQALQCSHYSILWQLVKITEGCPSKDDLLALRRVVKSFLAVCQQCLSNVNT 781

Human   794 EIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSELASFLMDHVFIQPGDLG---SG 855
            .::||||:||.|||:|||.|::.|||:.|:||||.|:.:||:||.:|::|||||...|..   .|
Zfish   782 PVKEQAFMLLCDLLMIFSHQLVSGGREGLQPLVFNPDGSLQNELLNFVLDHVFIDQDDENQSMEG 846

Human   856 DSQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNKFYNDYGDIIKETLTRARQID 920
            |.:::..:||.||:||.|||.||||::|.:::|.||:|:||.|.|:||||||||||||::.||:|
Zfish   847 DEEDEANKIEALHKRRNLLAAFCKLIIYDIVDMPAAADIFKQYMKYYNDYGDIIKETLSKTRQMD 911

Human   921 RSHCSRILLLSLKQLYTELLQEHGPQGLNELPAFIE-MRDLARRFALSFGPQQLQNRDLVVMLHK 984
            :..|::.|:|||:||:.||:|:.|| .|:...:.:. :::|||||||:||..|::.|:.|..|||
Zfish   912 KIQCAKTLILSLQQLFNELIQDQGP-NLDRTSSHVSGIKELARRFALTFGLDQIKTREAVATLHK 975

Human   985 EGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLSYLEKCL-QHVSQAPGHPWGP 1048
            :||:|:.....|.|....||||||||:|.|||.:|..|||:.:.|||||.: :::.:.....|.|
Zfish   976 DGIEFAFKVPNPKGPEYPPPNLAFLEVLCEFSSKLLRQDKKTVHSYLEKFMTEYMMERREDVWLP 1040

Human  1049 VTTYCHS---------LSPVENTAETSPQVLPSSKR-RRVEGPAKPNREDVSSS---QEESLQLN 1100
            :..|.:|         ||.....:.||......||| |..:...:|:.|.|..|   :.::||..
Zfish  1041 LIAYRNSLLTGGDDDRLSVTTGASSTSKASTVRSKRGRPPQHKRRPDEESVEGSWVMRNDTLQTP 1105

Human  1101 SIPPTPTLTSTAVKS--RQPLWGLKEME-EEDGSELDF------------AQGSQPVAGTERSRF 1150
            ....||.||||.::.  ||....:.:.: .|.|||.|:            .|..:.|...|||
Zfish  1106 GGLHTPQLTSTVLRENPRQAADHIPDQDSSEPGSEPDYMHNPQMQMSWLDQQKMEEVNRKERS-- 1168

Human  1151 LGPQYFQTPHNPSGPGLGNQLMRLSLMEEDEE---EELEIQ-----DESNEERQDT---DMQAS- 1203
             |..|.::    ...|:..|:.  .|||:|.|   |::.:.     ::.|||.:||   |:.||
Zfish  1169 -GMNYMKS----RSAGVRQQVR--GLMEDDAEPIFEDVMMSSRGQLEDMNEEFEDTMVIDLPASR 1226

Human  1204 SYSSTSERGLDLLDSTELDIEITESLPLLGQR 1235
            :....:|...|..|||    .|.|..|..|.:
Zfish  1227 NRRERAELRPDFFDST----AIMEDDPGFGMQ 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STAG3	XP_016867172.1	None
stag1b	XP_692120.3	IRR1	10..>394	CDD:227824	233/388 (60%)
stag1b	XP_692120.3	STAG	156..264	CDD:285686	77/107 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3773
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760