DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PLK4 and SAK

DIOPT Version :9

Sequence 1:	XP_016863151.1	Gene:	PLK4 / 10733	HGNCID:	11397	Length:	971	Species:	Homo sapiens
Sequence 2:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster

Alignment Length:	975	Identity:	327/975 - (33%)
Similarity:	476/975 - (48%)	Gaps:	273/975 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    10 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL 74
            |||::|.:|||||.||.||:|..:||..:|||||||||.:...|:..||:.||:||.:|||||:|
  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75

Human    75 ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLT 139
            :||.:|:|:||||||||:.||||::||:.:..:||:|.||...:.|::.|:||||||.|:|||::
  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140

Human   140 LSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYT 204
            ||||||:|.|::||||||||||||.|.|:|.|:||||||||||:.:|::|||.:||||:|||.||
  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205

Human   205 LLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRN 269
            ||:|||||:||.|::||||||:::|.||:.||.||:|||::||::.|.:|::|.:||.||||.:.
  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270

Human   270 SSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTD 334
            |              :.||:.                             |..:.||.::..|.|
  Fly   271 S--------------NGGHSA-----------------------------PGALNVFSQSMESGD 292

Human   335 -----FSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKT 394
                 |:||...||...    :...|||..:|:....|.....:.:..|
  Fly   293 SGIITFASSDSRNSQQI----RSVENSGPQQVLPQIREEFKQVHHKLPY---------------- 337

Human   395 YTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLC 459
                                                     |:|    |.|
  Fly   338 -----------------------------------------EQT----GLF-------------- 343

Human   460 PGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTK 524
             |:.....|:|        .|.|..:.:|...:....    ||             ||.|
  Fly   344 -GQASTGLAEP--------NWPGAAKSSAFCMEAGNV----PN-------------SKQA----- 377

Human   525 VKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLR 589
                        |:|:.                                               |
  Fly   378 ------------SLKED-----------------------------------------------R 383

Human   590 SITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVK---EYASQEYVKEVLQISSDGNTITIYY 651
            ....||...||.|.|.|||.|::|||.:.||.:|.:|   .| :::.:.::.:||.||..|.||.
  Fly   384 ISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTY-NEDRINDICRISDDGQRIIIYQ 447

Human   652 PNGGRGFPLADRPPS---PTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKC 713
            |:.|||.|:.::||.   |:.:.. |::||||.|:|:||.|.:|||.||:||:||:|||:...||
  Fly   448 PDPGRGLPVREQPPDLQIPSGDCV-YNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKC 511

Human   714 ILMENSPGADFEVWFYDGVKIHKT-EDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGH 777
            .|||..  .|||:.||.|.|:.|| .:.::|.::.|...:..|.||..||       ::|.||..
  Fly   512 QLMETM--TDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLSDYSCSESRSL-------IEHGNECF 567

Human   778 RICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSP----KALSPPPSVDSNYPTRERASFNRM 838
            ..|:.:.:.:...:.|..|.  ||:.|||:|.:...|    ..|....::..:.|...:.|.|..
  Fly   568 THCVNISNALEVAQTKDNSC--FPVTIGRRPITDVQPAQRLDGLRDTTNIAFSTPKSNQGSINFS 630

Human   839 VMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDIS-SNSL--KDCLPKSAQLLKSVFVKNVGWA 900
            :  |..|.|:                .|:..||:.| ||.|  ...:|     :|.:.|..:|.|
  Fly   631 L--STISSTR----------------NTSDFGTNCSRSNMLAAHQNIP-----IKRINVPEIGIA 672

Human   901 TQLTSGAVWVQFNDGSQLVV----QAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL 961
            |:|:.|.|.|||.|||.:.|    |.|  .|:||.|||.:|.:|:.:.||..::.::..:.:|.|
  Fly   673 TELSHGVVQVQFYDGSVVSVIPSMQGG--GITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNIQL 735

Human 962 961
Fly 736 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLK4	XP_016863151.1	None
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	154/254 (61%)
		S_TKc	14..267	CDD:214567	152/252 (60%)
		POLO_box_Plk4_1	382..497	CDD:240557	49/163 (30%)
		POLO_box_Plk4_2	498..596	CDD:240558	38/108 (35%)
		POLO_box_Plk4_3	657..738	CDD:240559	30/86 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148766
Domainoid	1	1.000	344	1.000	Domainoid score	I1058
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7962
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1180
Isobase	1	0.950	-	0	Normalized mean entropy	S2938
OMA	1	1.010	-	-		QHG50064
OrthoDB	1	1.010	-	-		D342340at33208
OrthoFinder	1	1.000	-	-		FOG0007296
OrthoInspector	1	1.000	-	-		oto88500
orthoMCL	1	0.900	-	-		OOG6_106331
Panther	1	1.100	-	-	LDO	PTHR24345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9746
SonicParanoid	1	1.000	-	-		X5399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750