DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L1 and yme1l1b

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_001317997.1	Gene:	yme1l1b / 557907	ZFINID:	ZDB-GENE-070410-25	Length:	715	Species:	Danio rerio

Alignment Length:	779	Identity:	572/779 - (73%)
Similarity:	630/779 - (80%)	Gaps:	70/779 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTK 65
            |||||:|:||||||.|||||||.|:.|. ||| |..||| ::||:..||.:..|:|
Zfish     1 MFSLSTTLQPQVTVQLSHLINALHSLKG-SVS-SNTSVS-HKHRENTPEQDLNSTE--------- 53

Human    66 LNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQ 130
                                                            |||:|||||||:|.:.|
Zfish    54 ------------------------------------------------PSLSLRDLGLSDLGLVQ 70

Human   131 IDQLVENLLPGFCKG----KNISSHWHTSHVSAQSFFENKYGNLDIFSTLR--SSCLYRHHSRAL 189
            ||:|:|.|||...:.    |.:...|.|||:|:.|||.||:|    ||.:.  :....|.:...|
Zfish    71 IDELLEKLLPRVSQQDSQLKTVPDIWRTSHLSSDSFFHNKHG----FSRMGGVTPVFSRQNQSPL 131

Human   190 QSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKL 254
            |::|:||.|.|:.:|:||||||||||||||...|...|.:.|.|||:||||.||:|.|||:|:||
Zfish   132 QTLCTDLNYLPLLVQNRGFKTLKSRTRRLQGGFEGPVEPEGITPSFMKGFLTRDKGPDVETLEKL 196

Human   255 MKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFR 319
            :|.|||||...|||||||||||||||||||:|.:|||||||||.||||.|:|||.|.||||||||
Zfish   197 LKNKNIPEGQHDAFKTGFAEGFLKAQALTQRTQESLRRTRLILLVLLLVGLYGLSKTPFLSVRFR 261

Human   320 TTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTG 384
            ||:||||||||||||||||||||||||||.|||||||||:||||||:||||||||||||||||||
Zfish   262 TTSGLDSAVDPVQMKNVTFEHVKGVEEAKNELQEVVEFLRNPQKFTVLGGKLPKGILLVGPPGTG 326

Human   385 KTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE 449
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
Zfish   327 KTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKGNAPCVIFIDELDSVGGKRIE 391

Human   450 SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTE 514
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   392 SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTE 456

Human   515 ILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILM 579
            ||||||.|||.|.:|:.|:|||||||||||||||||||||||||||||:|||||||||:||||||
Zfish   457 ILKWYLKKIKVDSAVEAEVIARGTVGFSGAELENLVNQAALKAAVDGKDMVTMKELEFAKDKILM 521

Human   580 GPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETR 644
            ||||||.|||.:||.||||||||||||||||||||||||||||||||||||||:|||||||:|||
Zfish   522 GPERRSAEIDKRNKEITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSMLPENDRWSETR 586

Human   645 AQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKL 709
            ||||||||||||||||||||||.::||||||||||:||||||.|||:||||||||||||||..|.
Zfish   587 AQLLAQMDVSMGGRVAEELIFGNENITTGASSDFDSATKIAKMMVTRFGMSEKLGVMTYSDLTKQ 651

Human   710 SPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR 773
            |||||:|||.|:||||||||||||.:||:.||||:|||||||.||||||||||:|||||.:..|
Zfish   652 SPETQAAIEHEVRILLRDSYERAKALLKSRAKEHRNLAEALLRYETLDAKEIQLVLEGKAINSR 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	60/63 (95%)
		FtsH_fam	333..766	CDD:273520	394/432 (91%)
		AAA	375..506	CDD:278434	129/130 (99%)
		Peptidase_M41	586..764	CDD:279742	153/177 (86%)
yme1l1b	NP_001317997.1	FtsH_fam	275..708	CDD:273520	394/432 (91%)
		AAA	317..448	CDD:278434	129/130 (99%)
		Peptidase_M41	528..704	CDD:279742	151/175 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327435
Domainoid	1	1.000	347	1.000	Domainoid score	I5946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31996
Inparanoid	1	1.050	1058	1.000	Inparanoid score	I2062
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53805
OrthoDB	1	1.010	-	-		D126890at7742
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		oto48335
orthoMCL	1	0.900	-	-		OOG6_101196
Panther	1	1.100	-	-	LDO	PTHR23076
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410