Protein Alignment YME1L1 and rept

DIOPT Version :9

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_001262040.1
• Gene: rept / 40092
• FlyBaseID: FBgn0040075
• Length: 481
• Species: Drosophila melanogaster
• Alignment Length: 480
• Identity: 93/480 - (19%)
• Similarity: 179/480 - (37%)
• Gaps: 120/480 - (25%)

Human   323 GLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLP-KGILLVGPPGTGKT 386
            |||..::    ..:..:.:.|.::|::....||:.::.        ||:. :.|||.|.|.||||
  Fly    28 GLDDVLE----ARLVSQGMVGQKDARRAAGVVVQMVRE--------GKIAGRCILLAGEPSTGKT 80

Human   387 LLA--RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGK--- 446
            .:|  .|.|...:.||...||||    ...:..|:...| .:|...:..|...:|.:.:.|:
  Fly    81 AIAVGMAQALGTETPFTSMSGSE----IYSLEMSKTEAL-SQALRKSIGVRIKEETEIIEGEVVE 140

Human   447 -RIESPMHPYSRQT--INQLLAEM----------------DGFKPNEGVIIIGATNFPEALDNAL 492
             :||.|.....::.  :.....||                :..:..:.:.|..|:.....|..:.
  Fly   141 IQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKASGKVNKLGRSF 205

Human   493 IRPGRFDMQ------VTVPRPDVKGRTEILKWY-LNKIKFDQSVDPEIIARGTVG----FSG--- 543
            .|...:|..      |..|..:::.|.|::... |::|        ::|...|.|    |||
  Fly   206 TRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEI--------DVINSRTHGFLALFSGDTG 262

Human   544 ---AELENLVNQAALKAAVDGK----------EMVTMKELE-FSKDKILMGPERRSVEIDNKNKT 594
               .|:.:.:|...|:...:||          :.|.|.::| ||.....:..:...|.:...|:.
  Fly   263 EIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATNRG 327

Human   595 ITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRV 659
            ||....:.     |.:...:||:   ::.|   :..:..:|.:::  |.:..|..:.:
  Fly   328 ITRIRGTN-----YRSPHGIPID---LLDR---MIIIRTVPYSEK--EVKEILKIRCE------- 372

Human   660 AEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIE------ 718
            .|:.|...|.:|.......|.:.:.|.:::|               |..|....:.|.|
  Fly   373 EEDCIMHPDALTILTRIATDTSLRYAIQLIT---------------TANLVCRRRKATEVNTEDV 422

Human   719 QEIRILLRDSYERAKHILKTHAKEH 743
            :::..|..|. .|:..|||.:..::
  Fly   423 KKVYSLFLDE-NRSSKILKEYQDDY 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	18/66 (27%)
		FtsH_fam	333..766	CDD:273520	90/470 (19%)
		AAA	375..506	CDD:278434	35/160 (22%)
		Peptidase_M41	586..764	CDD:279742	28/164 (17%)
rept	NP_001262040.1	TIP49	17..408	CDD:283678	84/439 (19%)
		P-loop_NTPase	69..>113	CDD:304359	19/47 (40%)
		AAA	<267..358	CDD:99707	18/101 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910