DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L1 and Pex6

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	165/669 - (24%)
Similarity:	264/669 - (39%)	Gaps:	141/669 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    19 LINAFHTPK--------NTSVSLSGVSVSQNQHRDVVPEH-----------EAPSSECMFSDFLT 64
            |.|.|:||:        ...|:...|..:...|..::..|           |...||......:.
  Fly   237 LSNYFNTPRLMHRGHTYRIEVNAELVGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVA 301

Human    65 K--LNIVSIGKGKIF------------EGYRSMFMEPAKRMKKSLDT--------TDNWHIRPEP 107
            |  .|:|.:.....|            |.|.|...:|.|.::.|:|.        ..:.||.| .
  Fly   302 KNFSNLVQVPASHSFLPRQVLDSMAIVENYPSGLRKPYKLLRSSVDAFLPKKSACLSSKHIFP-V 365

Human   108 FSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKG--KNISSHWHTSHVSAQSFFENK---- 166
            |.|.     ..|..|.|:|......:|..::....|..  ..:.||   :.:..::.|...
  Fly   366 FLLQ-----GERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSH---TEMKLKAVFAKSQVCE 422

Human   167 -----YGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVF-IQSRGFKTLKSRTRRLQSTSERL 225
                 :.|.:||......             ..||:....| :|   .:.|.:|.|:.......|
  Fly   423 PLMICFHNFEIFGIDNEG-------------NEDLRLLSAFHVQ---VQELFNRDRKHPIVVVAL 471

Human   226 AETQNIAPSFVKGFLLRDRGSDVESLD---KLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTN 287
            ...:::.| .::|..|.....|:.|.:   ::::..::.|...|..   :.:..::...|..:.|
  Fly   472 TSDRHLKP-MIQGLFLEIINIDMPSKEERFEILRWMHVRETFNDII---YNQKAIEQLPLFSREN 532

Human   288 DSLRRTRL------ILFVL---------LLFGIYGLLKNPFLSVRFRTTTG-------------- 323
            .|....|:      .|.||         .|.|...||.:..:.::.|...|
  Fly   533 QSQFMPRISPSWRETLNVLQDVAAKSQGFLLGDLQLLYDNAVRMKIRNRLGRTTLDMSHFAKNLT 597

Human   324 ------LDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGK--LPKGILLVGP 380
                  .||...| ::..|.:..:.|:.:.|.|:|..:..   |.|...|.||  ...||||.||
  Fly   598 DMQSSFADSLGAP-KVPKVYWSDIGGLAKLKDEIQSSIGL---PLKHVHLMGKNLRRSGILLYGP 658

Human   381 PGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGG 445
            |||||||:|:|||.|.::.|....|.|...|:||.....:|.:|..|::.||||:|:|||||:..
  Fly   659 PGTGKTLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAP 723

Human   446 KR-IESPMHPYSRQTINQLLAEMDGF------KPNEGVIIIGATNFPEALDNALIRPGRFDMQVT 503
            .| :.........:.::||||||||.      ||   :.|:.|||.|:.:|.||:||||||....
  Fly   724 NRGVAGDSGGVMDRVVSQLLAEMDGMSDGDTSKP---IFILAATNRPDLIDPALLRPGRFDKLFY 785

Human   504 V-PRPDVKGRTEILKWYLNKIKFDQSVDPEIIA-RGTVGFSGAELENLVNQA---ALKAAVDGKE 563
            | |....:.:..:|:....:...|..||.|.|| |.....|||:|.::.:.|   |::..:||..
  Fly   786 VGPCSTAEDKAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHL 850

Human   564 MVTMKELEFSKDKILMGPE 582
            ..|:.|.|...:.:::..|
  Fly   851 SGTISEKELVPENVIVQEE 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	27/65 (42%)
		FtsH_fam	333..766	CDD:273520	94/264 (36%)
		AAA	375..506	CDD:278434	62/138 (45%)
		Peptidase_M41	586..764	CDD:279742
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	132/514 (26%)
		P-loop_NTPase	367..492	CDD:304359	24/149 (16%)
		AAA	653..787	CDD:278434	61/136 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910