Protein Alignment CFL2 and COF1

DIOPT Version :10

• Sequence 1: NP_068733.1
• Gene: CFL2 / 1073
• HGNCID: 1875
• Length: 166
• Species: Homo sapiens
• Sequence 2: NP_013050.1
• Gene: COF1 / 850676
• SGDID: S000003973
• Length: 143
• Species: Saccharomyces cerevisiae
• Alignment Length: 150
• Identity: 58/150 - (38%)
• Similarity: 86/150 - (57%)
• Gaps: 23/150 - (15%)

Human     3 SGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDP 67
            |||.|.||.:..|||:|         :.|:.|.:||.|:|.|.:|:|:|           |..||
Yeast     4 SGVAVADESLTAFNDLK---------LGKKYKFILFGLNDAKTEIVVKE-----------TSTDP 48

Human    68 -YTSFVKLLPLNDCRYALYDATYET--KESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFT 129
             |.:|::.||.|||.||:||..||.  .|.|:..:||..|:|::||::|||:|||||||:::...
Yeast    49 SYDAFLEKLPENDCLYAIYDFEYEINGNEGKRSKIVFFTWSPDTAPVRSKMVYASSKDALRRALN 113

Human   130 GIKHEWQVNGLDDIKDRSTL 149
            |:..:.|.....::...|.|
Yeast   114 GVSTDVQGTDFSEVSYDSVL 133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFL2	NP_068733.1	Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	2..55		20/51 (39%)
		ADF_cofilin_like	3..153	CDD:200442	57/149 (38%)
		Nuclear localization signal. /evidence=ECO:0000255	30..34		1/3 (33%)
		Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	55..105		20/52 (38%)
COF1	NP_013050.1	ADF_cofilin_like	4..136	CDD:200442	57/149 (38%)