Protein Alignment CFL2 and F53E2.2

DIOPT Version :10

• Sequence 1: NP_068733.1
• Gene: CFL2 / 1073
• HGNCID: 1875
• Length: 166
• Species: Homo sapiens
• Sequence 2: NP_503425.2
• Gene: F53E2.2 / 41657006
• WormBaseID: WBGene00302980
• Length: 165
• Species: Caenorhabditis elegans
• Alignment Length: 173
• Identity: 53/173 - (30%)
• Similarity: 87/173 - (50%)
• Gaps: 29/173 - (16%)

Human     1 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEA-KQILVGDIGDTV 64
            |:|||.|:.:|...|..:        .|.:|..:.::|.:  |:.::|||.| .|..:|..||..
 Worm     1 MSSGVMVDPDVQTSFQKL--------SEGRKEYRYIIFKI--DENKVIVEAAVTQDQLGITGDDY 55

Human    65 ED----PYTSFVKLLP-----LNDCRYALYDATYETKE-----SKKEDLVFIFWAPESAPLKSKM 115
            :|    .:..||:.:.     |.|||||::|..:....     ||.:.::|:...|:.|.:|.||
 Worm    56 DDSSKAAFDKFVEDVKSRTDNLTDCRYAVFDFKFTCSRVGAGTSKMDKIIFLQICPDGASIKKKM 120

Human   116 IYASSKDAIKKKF-TGIKHEWQVNGLDDIKDR---STLGEKLG 154
            :||||..|||... ||...::||:...::..:   :.||||.|
 Worm   121 VYASSAAAIKTSLGTGKILQFQVSDESEMSHKELLNKLGEKYG 163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFL2	NP_068733.1	Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	2..55		14/53 (26%)
		ADF_cofilin_like	3..153	CDD:200442	50/168 (30%)
		Nuclear localization signal. /evidence=ECO:0000255	30..34		1/3 (33%)
		Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	55..105		16/63 (25%)
F53E2.2	NP_503425.2	ADF_cofilin_like	3..158	CDD:200442	47/164 (29%)