DRSC/TRiP Functional Genomics Resources

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Protein Alignment NFAT5 and NFAT

DIOPT Version :9

Sequence 1:NP_619727.2 Gene:NFAT5 / 10725 HGNCID:7774 Length:1549 Species:Homo sapiens
Sequence 2:NP_001096974.1 Gene:NFAT / 32321 FlyBaseID:FBgn0030505 Length:1457 Species:Drosophila melanogaster


Alignment Length:1400 Identity:351/1400 - (25%)
Similarity:555/1400 - (39%) Gaps:376/1400 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    49 LPKELQLPPSRETSVASMS-------QTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSS 106
            :|:....||...::.:.:.       ::|.|..|...||......|::...||:           
  Fly   136 IPQRPHPPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSL----------- 189

Human   107 SPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPS------------------- 152
               :.::::|::.|....:.::||            .|||:|||..                   
  Fly   190 ---LVNSALTNTVAAAAAAAAAAV------------ASNTLQQHQQHHQQQQQQQQQQQQQQQQQ 239

Human   153 ---------TPKRHTVLYISPPPEDLLDNSRM-------------SCQDEG-----CGLESEQSC 190
                     :|::|.:..|  |.....:|:::             |.:|..     .||:.:.. 
  Fly   240 QQQQQQQQHSPQQHLIRAI--PVSRSRNNTKVMAHCLEDLDLISASSEDSSTIATPAGLDEDTG- 301

Human   191 SMWMEDSPSNFSNMSTSS---------------------------------------YNDNTEVP 216
              ::.|:.:..:..::||                                       ||.....|
  Fly   302 --FVNDTKTTTTGGNSSSDPFGGVFQATEAAVAAAVNAFNLQQQQHSVQQQQHQLFQYNGLLLQP 364

Human   217 -----------RKSRKRNPKQRPG--VKRR--DCEESNMDIFDADS------------------- 247
                       ::.:::....|.|  :||:  :|.:..:|..||.|                   
  Fly   365 QQQLQQQQSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDDACSEDEFIRKIASSVTMSPTLE 429

Human   248 ----------AKAP-HYVLSQLTTDNKGNSKAGNG---------TLENQKGTGVKKSPMLCGQYP 292
                      :.|| ..::|.|...:.|||...|.         :..|......|:.|..    |
  Fly   430 ATPSPPPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFISARNVTRVANKRQPTT----P 490

Human   293 VKS-----EGK-ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGN 351
            :.|     :|: :|:|:.|||.||||||.||||||:||||:..|||.|:|.|:::..|||||:|.
  Fly   491 LNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDKVAVLQVFIGT 555

Human   352 DSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEAR 416
            |.|||.||.|||||:|.|:|:|.|.|..::||.|||:...|..:||:..|||||||.||.|||.|
  Fly   556 DIGRVAPHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHR 620

Human   417 IG---IAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGE 478
            ..   ...:||||||.|:|||..:.|.||:|.|||..|:||:||||.|||||.||||:||.|.|.
  Fly   621 FPEHLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQPPGVPEICKKSLNSCPVDGG 685

Human   479 EEVFLIGKNFLKGTKVIFQENVSDENS--------------------WKSEAEIDMELFHQNHLI 523
            .|:|:|||||||.|.|:|||.....|.                    |:.....|.|..||.|||
  Fly   686 LELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLI 750

Human   524 VKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDP-----AAAGALNVNV-KKEIS---- 578
            ..||||..|:|..||.|.:.:| ::|:..:...||||...     |||..|:..: .:::|    
  Fly   751 CTVPPYLHQNILKPVQVQVSIV-SSGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMD 814

Human   579 -SPARPCSFEEAMKAM------KTTGCNLDKVNIIPNALMTPLIPSSMIKSEDVTPMEVTAEKRS 636
             :.|...|......|.      .:||.|::..:.|.:.:|.|.|.:.:       ||.|    |.
  Fly   815 TTSASNASGSSGWSAAGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQI-------PMGV----RR 868

Human   637 STIFKTTKSVGSTQQTLENISNIAGNG----SFSSPSSSHLPSENEKQQ-------QIQPKAYNP 690
            |::...|..:  |.|.|.:::.:|.:.    :....|:||.|...|...       |....|..|
  Fly   869 SSLPSVTPMI--TDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKP 931

Human   691 ETLTTIQTQDISQPGTFP---------AVSASSQL-PNSDA--------------LLQQATQFQT 731
            ...|.:..|..|.|| ||         ||:|:..: |.:.|              ::||..|.|.
  Fly   932 SLDTIMYDQSNSLPG-FPTVVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQE 995

Human   732 RETQSREILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQ----------QISSN------IF 780
            :..:.::..|        .|..:..|||||.|.|:|.|.:.:          .:|||      :|
  Fly   996 QMHEQQQQQQ--------QQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALF 1052

Human   781 PSPNSVSQLQNTIQQLQAG--------------SFTGSTAS-----GSSGSVDLVQQVLEAQQQL 826
            .:...:......|.|.:.|              |.|.|::|     .|..|..|.|.::...:..
  Fly  1053 TTSAVIDHALTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPA 1117

Human   827 SSVLFSAPDGNE---NVQEQLSADIFQQVSQIQSGVSPG--MFSSTEPTVHTRPDNLLPGR---A 883
            :::..:|..|..   :|...||.||.     :...|||.  :.|:........|:.|.|.:   |
  Fly  1118 AALAGAAALGGPAPVDVTGGLSTDII-----MNPAVSPSTILCSANGAATAVVPNILAPHQVTMA 1177

Human   884 ESVHPQSENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSP 948
            .|:    .|.::.|.:..||...|...:.:.:| |......:...:...|.|:.|:....:..:.
  Fly  1178 NSI----LNDIAMQPEPTQQDAAVAALALSNIM-MSPPTAASGVGVGDTLPPTPATMQPEVAATA 1237

Human   949 VYQQTSHMM-----SALSTNEDMQMQC----ELFSSPP----AVSGNETSTTTTQQVATPGTTMF 1000
            .....|:|:     ..::|.|..|...    .:.|..|    .||||...|.:...|    ..:.
  Fly  1238 TSTAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLV----DLLL 1298

Human  1001 QTSSSGDGEETGTQAKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSG---TQQQGNG 1062
            ..|::.:.......|..::.:.||:|....||.... ..:......|.::...||   :..:|:.
  Fly  1299 NHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGH-HGHSHGHGHSRVTGHVSGHVTSHHRGHH 1362

Human  1063 L-----FQQGNEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQT 1122
            |     ..|.:.:::|.|.|.||:|..:.|  ......:...|..:..|.||:.    |......
  Fly  1363 LPVVPPTPQESLIVALASENALQKSVATAA--VTTNGAVMTQQASAPNTAGSIL----PAAVGAV 1421

Human  1123 STTSSEQMQPPM------FHSQSTIAVLQGSSVPQ 1151
            :..::..:|||:      ...|..|:.:..|:..|
  Fly  1422 AAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQ 1456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NFAT5NP_619727.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..107 10/61 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 132..159 8/54 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..238 11/98 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..283 5/32 (16%)
RHD-n_TonEBP 298..458 CDD:143642 92/163 (56%)
IPT_NFAT 462..561 CDD:238583 49/118 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..684 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..909 14/54 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 976..1014 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1322
TFIIA 1300..>1461 CDD:281188
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1334..1389
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1491..1520
NFATNP_001096974.1 RHD-n_TonEBP 502..665 CDD:143642 92/162 (57%)
IPT 669..787 CDD:301692 49/118 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147119
Domainoid 1 1.000 165 1.000 Domainoid score I3921
eggNOG 1 0.900 - - E1_28KEG
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006955
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_107943
Panther 1 1.100 - - O PTHR12533
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4940
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.860

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