DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OGA and Oga

DIOPT Version :9

Sequence 1:	NP_036347.1	Gene:	OGA / 10724	HGNCID:	7056	Length:	916	Species:	Homo sapiens
Sequence 2:	NP_650956.1	Gene:	Oga / 42518	FlyBaseID:	FBgn0038870	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	1034	Identity:	375/1034 - (36%)
Similarity:	563/1034 - (54%)	Gaps:	191/1034 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    51 AGA-AGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELN---TYLYAPKDDYKHRMFWREMY 111
            ||: |.|.|:|:|||:||||||||..||||:|||:|:...:.   :|:||||||||||.:|||:|
  Fly     5 AGSQADGKRQFICGVIEGFYGRPWTTEQRKDLFRKLKSMGMGSSPSYMYAPKDDYKHRAYWRELY 69

Human   112 SVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDI 176
            :||||:.|.:||:||:|..|.|.||:|||||:|:|:|||::|||||||||:||||.::|||||||
  Fly    70 TVEEADHLSSLIAAAKEAGITFYYALSPGLDMTYSSPKEIATLKRKLDQVAQFGCEAYALLFDDI 134

Human   177 DHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKL 241
            :..:..||||||.:||:|.||:|||||.:||.|. ||||||:||.:...|.|.:|.||.|:|.||
  Fly   135 ESELSKADKEVFQTFANAHVSVTNEIYTHLGSPR-FLFCPTQYCASRAVPTVQESEYLNTLGSKL 198

Human   242 LPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPR 306
            ...|::||||.||:||.|.:|||:|::::::|.|.||||:|||||||||:|:|||.|||.||||.
  Fly   199 NNEIDILWTGDKVISKNISLESIQEITEVLRRPPCIWDNLHANDYDQKRIFMGPYSGRSPELIPH 263

Human   307 LKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSE-DSTVSIQIKLENEGSDEDIET 370
            |:||:|||||||..|:||||:||.|.:.::          ||: :|::|..||||.| :|:|:..
  Fly   264 LRGVMTNPNCEFYGNFVAIHSLAFWSRCSL----------DSKVNSSLSADIKLETE-NDDDLPA 317

Human   371 DVL----YSPQMALKLALTEWLQEFGVPHQ----------------------------------- 396
            :.|    |.|::|||.|:||||.||.:..:
  Fly   318 EFLSKNVYHPRLALKNAITEWLPEFFMKKEAWGPITKPQPQVQMVMPIIPIIPSINTCMSLTTTT 382

Human   397 ---YSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAA----------LSGEP 448
               .|||.|      ...|:.|.|.|...:...|...|....|:|:...:          ::..|
  Fly   383 TTSTSSRTV------PPTVNTTQLQALADVCVVTSSLTPISNPVMNSLVSPTKVITNDDIINPIP 441

Human   449 TTLTKEEE--KKQP-DEEPMDMVVEKQEETDHK--------NDNQI--LSEIVEAKMAEELKPMD 500
            ||.....|  ||.| ...|:.::..|..|...:        :||:|  .|:.|:.::..|:. ::
  Fly   442 TTAASNIELPKKIPISVVPVPIMETKSVEASVELALDNAVFDDNEIEPNSDSVKERLELEVN-LE 505

Human   501 TDKESIA----------ESKSP-----------------EMSMQE-------------DCISDIA 525
            ..:|.:|          :|.||                 ::|.:|             :.::|:.
  Fly   506 GKQEPVANLSVDTMLDDDSLSPLSGVVNEPMECSSSITSQVSPREEEAIKVVADDVLMESVNDVH 570

Human   526 PMQTDEQTNK-----------EQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQML 579
            .|..:..|:.           |......|:......|.:|::||.||.||||||:|||.:|.::|
  Fly   571 SMHVESGTSSPISNAEMREETEAQSDRTNDNNTIEGEGITVDDLVLLCDLFYLPFEHGSRGHKLL 635

Human   580 REFQWLRANSSVV----SVNCKG----KDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTI 636
            .||.||:.|::|:    |....|    .|..::.||..|..:|:::|..|:.:..:::||.|:.|
  Fly   636 VEFNWLKGNANVILQDRSAGGGGDAIKSDKPEVSEWHQRREQFDQLCSAVVELLIKIANCPNKEI 700

Human   637 LYDMYSYVWDIKSIMSMVKSFVQWLGC----RSHSS--------------AQFLIGDQEPWAFRG 683
            .:::|||:|||...:|::..:|:||..    ::.||              ..|:.||||||.|||
  Fly   701 CHELYSYMWDISGALSLLNCYVKWLALGHFPQNTSSYTEGSYTWFSKGWKEAFMSGDQEPWVFRG 765

Human   684 GLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMY-------DDGVG 741
            ||..:.|||:|:|..||||....|..||:..|.:|||...||..|..:|..:|       |.|..
  Fly   766 GLIADLQRLMPVDSGNDLFVYKLPEQPTANYYLLRPYCNSDEQQVNDLCTRLYLQWRGELDGGRH 830

Human   742 LPF---QSQPDLIGDKLVGGLLSLSLDYCFVLEDEDG-ICGYALGTVDVTPFIKKCKISWIPFMQ 802
            :||   .:.|:::.|.|:||.|:||...|.|..||.. |.||:...:||..|.:..::.|...::
  Fly   831 IPFPLPANVPNIVADGLIGGYLTLSPQLCIVAYDESNRIIGYSCAALDVNIFRRNLELCWYTELR 895

Human   803 EKYTK-----PNGDKELSEAEKIMLSFHEEQ-----EVLPETFLANFPSLIKMDIHKKV--TDPS 855
            |||::     ..|::.:.....::.|:|:..     :..|.....:||:::.....::.  .|..
  Fly   896 EKYSRDICPLEGGEEVVQLVTSLVESYHDSSGNGALDQCPVEVSGSFPAVLISGTLREAEERDSG 960

Human   856 VAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGR 914
            :.|.|:..||::|:|||..||...|...|...:.|||::|..::.:.|.  ...:.:||
  Fly   961 ITKRMLTVLLAALRANGCFGAHVRVPQQDVAQVNFYSRIGFVDVYREEA--TKCIYMGR 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OGA	NP_036347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		NAGidase	62..338	CDD:400097	172/278 (62%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q2CEE3	278..280		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..465		7/36 (19%)
Oga	NP_650956.1	NAGidase	17..286	CDD:284884	169/269 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156869
Domainoid	1	1.000	378	1.000	Domainoid score	I859
eggNOG	1	0.900	-	-		E1_KOG3698
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8154
Inparanoid	1	1.050	657	1.000	Inparanoid score	I778
Isobase	1	0.950	-	0	Normalized mean entropy	S5626
OMA	1	1.010	-	-		QHG47004
OrthoDB	1	1.010	-	-		D106930at33208
OrthoFinder	1	1.000	-	-		FOG0005508
OrthoInspector	1	1.000	-	-		oto88887
orthoMCL	1	0.900	-	-		OOG6_105534
Panther	1	1.100	-	-	LDO	PTHR13170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3928
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720