Protein Alignment AP4B1 and AP-1-2beta

DIOPT Version :10

• Sequence 1: NP_006585.2
• Gene: AP4B1 / 10717
• HGNCID: 572
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 191/644 - (29%)
• Similarity: 336/644 - (52%)
• Gaps: 67/644 - (10%)

Human    12 ELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYA 76
            |||..|.|.    .:.:.:..:::||..||.|.|:|.:|.::|....|.::..|||||||:..||
  Fly    17 ELKSELNND----KKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYA 77

Human    77 PLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAV 141
            ..:||:|::|:||..|||.|.||::|.||:|:|..:|:..:.||:.:|:...|:|:..|||:.|.
  Fly    78 KSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAA 142

Human   142 LGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEI---------LKQEGGVVINK 197
            :..||::::......|...:::|..||.|.:|:||.|.:.:|.||         |.:...|.|||
  Fly   143 VCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINK 207

Human   198 PIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFLIL 262
                 ||..:::..:|||..:|:.|..|.|:.|.|...|...:...|..::..||:.|.|   :|
  Fly   208 -----LLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSAVK---VL 264

Human   263 AKMFPHVQTD------VLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCS 321
            .|:...:.:|      :..::..||:...|||. |:.:|||.::..|:...|.......|.||..
  Fly   265 MKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEP-EVQYVALRNINLIVQKRPDILKHEMKVFFVK 328

Human   322 YSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIA---RTYTDQCV 383
            |::|.|:||:|::::..|.|..|:.|||.||:.|.|:|..||.:.|:.|||..|   ....::||
  Fly   329 YNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCV 393

Human   384 QILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCE--ENIQDSEGKQALIWLLGVH 446
            ..|.:|:..:..::....:...:|:....|...|::...|  ||  :.:.:.|.:.:::|::|.:
  Fly   394 STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTL--CENLDTLDEPEARASMVWIIGEY 456

Human   447 GERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAV 511
            .|||.||..:|:.|:|..:.|. ..|:::||||:::|||.||::.|:::..:|....::..:..:
  Fly   457 AERIDNADELLDSFLEGFQDEN-AQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520

Human   512 RDRGLFYYRLLLVGIDEVKRILCSPKS---------DPTLGLLEDPAERPVNSWASDFNTLVPVY 567
            ||||..|:|||.......|.::.:.|.         :|||          ::......::|..||
  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTL----------LDELICHISSLASVY 575

Human   568 GKAHWATI-SKCQGAERCDPELPKTSSFAASGPLIPEENKERVQELPDSGALMLVPNRQ 625
            .|...|.: .:..|..:   .||..::.:|:|       .|:.:....|.| |::||::
  Fly   576 HKPPTAFVEGRGAGVRK---SLPNRAAGSAAG-------AEQAENAAGSEA-MVIPNQE 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP4B1	NP_006585.2	Adaptin_N	9..525	CDD:396262	170/532 (32%)
		HEAT repeat	86..113	CDD:293787	14/26 (54%)
		HEAT repeat	120..150	CDD:293787	10/29 (34%)
		HEAT repeat	159..185	CDD:293787	9/25 (36%)
		HEAT repeat	198..222	CDD:293787	6/23 (26%)
		Hinge. /evidence=ECO:0000305|PubMed:26542808	534..600		14/75 (19%)
		Ear, mediates interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808	601..739		6/25 (24%)
		B2-adapt-app_C	621..731	CDD:462667	2/5 (40%)
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:396262	164/508 (32%)
		HEAT repeat	51..75	CDD:293787	10/23 (43%)
		HEAT repeat	87..114	CDD:293787	14/26 (54%)
		HEAT repeat	121..151	CDD:293787	10/29 (34%)
		HEAT repeat	160..186	CDD:293787	9/25 (36%)
		HEAT repeat	197..229	CDD:293787	12/36 (33%)
		HEAT repeat	393..417	CDD:293787	3/23 (13%)
		HEAT repeat	429..458	CDD:293787	6/30 (20%)
		HEAT repeat	465..495	CDD:293787	11/30 (37%)
		HEAT repeat	506..542	CDD:293787	10/35 (29%)
		Alpha_adaptinC2	703..799	CDD:197886
		B2-adapt-app_C	809..919	CDD:198088