DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP4B1 and rb

DIOPT Version :10

Sequence 1:NP_006585.2 Gene:AP4B1 / 10717 HGNCID:572 Length:739 Species:Homo sapiens
Sequence 2:NP_525071.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster


Alignment Length:565 Identity:142/565 - (25%)
Similarity:256/565 - (45%) Gaps:86/565 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    33 IQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDP 97
            ::|:|..:.:|.|.|.:|..:||...:.:|..|||||:|:..||..:.|||||:|:|..:...||
  Fly    64 MKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDP 128

Human    98 NPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVN 162
            |.::|..|||.:.|:|:..:...:...|.:...|.:.|||:.|.....|:::|..|.:.:  ||.
  Fly   129 NQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDE--LVM 191

Human   163 ELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRY-- 225
            .:..||.|:..:||.:.:.:.:|:..:...::...  ...|.|.:..:|:|||..::|.|.||  
  Fly   192 VIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKN--YRKLCNFLLDVDEWGQVIIINMLTRYAR 254

Human   226 ----QPRSEEELFDILN-------LLDSFL--------------------KS------------- 246
                .|.:::|  |::|       :.:.|.                    ||             
  Fly   255 TQFVDPNADDE--DLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGS 317

Human   247 ---SSPG----------VVMGATK---------LFLILAKMFPHVQTDVLVRVKGPLLAACSSES 289
               |||.          :::..||         :.:.:|:::.||.....|::....|.......
  Fly   318 RTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSH 382

Human   290 RELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRG 354
            :|:..|.|..:..:.......|..|.|.||...|:|.:|||.|:::|..|.:..::..:|.|.:.
  Fly   383 KEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQT 447

Human   355 YCTDVSADFAQAAIFAIGGIA---RTYTDQCVQILTELLGLRQEHI---TTVVVQTFRDLVWLCP 413
            |.:.....|..|.|.|||..|   :..|:.|:..|..||....||:   :.||::  |.|.....
  Fly   448 YISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIK--RLLQTKAA 510

Human   414 QCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIP-NAPYVLEDFVENVKSETFPAVKMELL 477
            :..|.:.| :....:.|.....:.|:|||:|.:.|::| .||.||....::...|. ..||:::|
  Fly   511 EHFEIITQ-MAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQ-DVVKLQVL 573

Human   478 TALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLL 522
            ...::|:|:.| |...:|.:.::.....:.:..||||..|..:::
  Fly   574 NLGVKLYLTNP-EQTSLLCQYVFTLARYDPNYDVRDRARFLRQII 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP4B1NP_006585.2 Adaptin_N 9..525 CDD:396262 142/565 (25%)
HEAT repeat 86..113 CDD:293787 10/26 (38%)
HEAT repeat 120..150 CDD:293787 7/29 (24%)
HEAT repeat 159..185 CDD:293787 7/25 (28%)
HEAT repeat 198..222 CDD:293787 7/23 (30%)
Hinge. /evidence=ECO:0000305|PubMed:26542808 534..600
Ear, mediates interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808 601..739
B2-adapt-app_C 621..731 CDD:462667
rbNP_525071.2 Adaptin_N 40..621 CDD:396262 142/565 (25%)
HEAT repeat 48..73 CDD:293787 2/8 (25%)
HEAT repeat 117..144 CDD:293787 10/26 (38%)
HEAT repeat 147..179 CDD:293787 7/31 (23%)
HEAT repeat 188..214 CDD:293787 7/27 (26%)
AP3B1_C 881..1019 CDD:464319
Blue background indicates that the domain is not in the aligned region.

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