Protein Alignment TBR1 and tbr1

DIOPT Version :10

• Sequence 1: NP_006584.1
• Gene: TBR1 / 10716
• HGNCID: 11590
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_001072587.1
• Gene: tbr1 / 780042
• XenbaseID: XB-GENE-942241
• Length: 677
• Species: Xenopus tropicalis
• Alignment Length: 688
• Identity: 589/688 - (85%)
• Similarity: 622/688 - (90%)
• Gaps: 17/688 - (2%)

Human     1 MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKIT-RGMTNQSD 64
            ||::||||.|:|||||||:|:.||||....||.||||||||:.|||||||||||.| |||||||:
 Frog     1 MQVDHCLSSSMMLSKKFLSVTGSYPHPAAPELALHDHPIISSADNLERSSPLKKATVRGMTNQSE 65

Human    65 TDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAP-SAMFPYPG 128
            .|:|..:||:|||.||||||||||||||:||||||||||||||.||||.||||:|| :.|||||.
 Frog    66 ADSFSGAKDAPGDGQRSKLSPVLDGVSEIRHSFDGSAADRYLLPQSSQSQSAASAPTTTMFPYPS 130

Human   129 QHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFS 193
            |||.||||||:|||.|||||||||.||||||||.||:|||||:|||||.||||||||.|||||||
 Frog   131 QHGAAHPAFSLGSPGRYMAHHPVIANGAYNSLLGNSAPQGYPSAGYPYSQQYGHSYQAAPFYQFS 195

Human   194 STQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVIL 258
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 ATQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVIL 260

Human   259 ADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQ 323
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
 Frog   261 ADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKMKLTNNKGASNNNGQ 325

Human   324 MVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFA 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   326 MVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFA 390

Human   389 KGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGP 453
            |||||||||||||||:|||||||||||||||||||||:||.:||||||||||||:|||| .||.|
 Frog   391 KGFRDNYDTIYTGCDLDRLTPSPNDSPRSQIVPGARYSMASTFLQDQFVSNYAKSRFHP-PGAVP 454

Human   454 GPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDF-AASAYDTATDFAGNAATLLSYA 517
            |||||||||||||||||||.|||||||||||||||||||||| :|||||.|||||||||||||||
 Frog   455 GPGTDRSVPHTNGLLSPQQGEDPGAPSPQRWFVTPANNRLDFTSASAYDAATDFAGNAATLLSYA 519

Human   518 AAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYL 582
            |||||||||...|||.||||||:||:||||||||||| ||||||||||    |...|||..||||
 Frog   520 AAGVKALPLPGGGCTARPLGYYSDPTGWGARSPPQYC-TKSGSVLPCW----ATGGRMAATNPYL 579

Human   583 --GEEAEGLAA-ERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPAD 644
              .||.|.||| :||||    .||.||||||||||||||.||||:|||||||||||||||:||:|
 Frog   580 TGSEEVESLAATDRSPL----GEDTKPKDLSDSSWIETPPSIKSMDSSDSGIYEQAKRRRLSPSD 640

Human   645 TPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS 682
            ..||.|||||||||:..|||||||.||:| |||||:|:
 Frog   641 PAVSGSSSPLKSEVVPPRDCEKNCTKDLS-YYGFYTHT 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..83		29/40 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..127		13/19 (68%)
		T-box_TBR1	203..393	CDD:410330	188/189 (99%)
		T-box_assoc	418..680	CDD:465042	212/265 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..483		31/35 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	588..658		54/70 (77%)
tbr1	NP_001072587.1	T-box_TBR1	205..395	CDD:410330	188/189 (99%)
		T-box_assoc	420..675	CDD:465042	212/265 (80%)