DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBR1 and tbr1

DIOPT Version :9

Sequence 1:	NP_006584.1	Gene:	TBR1 / 10716	HGNCID:	11590	Length:	682	Species:	Homo sapiens
Sequence 2:	NP_001072587.1	Gene:	tbr1 / 780042	XenbaseID:	XB-GENE-942241	Length:	677	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	589/688 - (85%)
Similarity:	622/688 - (90%)	Gaps:	17/688 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKIT-RGMTNQSD 64
            ||::||||.|:|||||||:|:.||||....||.||||||||:.|||||||||||.| |||||||:
Frog     1 MQVDHCLSSSMMLSKKFLSVTGSYPHPAAPELALHDHPIISSADNLERSSPLKKATVRGMTNQSE 65

Human    65 TDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAP-SAMFPYPG 128
            .|:|..:||:|||.||||||||||||||:||||||||||||||.||||.||||:|| :.|||||.
Frog    66 ADSFSGAKDAPGDGQRSKLSPVLDGVSEIRHSFDGSAADRYLLPQSSQSQSAASAPTTTMFPYPS 130

Human   129 QHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFS 193
            |||.||||||:|||.|||||||||.||||||||.||:|||||:|||||.||||||||.|||||||
Frog   131 QHGAAHPAFSLGSPGRYMAHHPVIANGAYNSLLGNSAPQGYPSAGYPYSQQYGHSYQAAPFYQFS 195

Human   194 STQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVIL 258
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   196 ATQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVIL 260

Human   259 ADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQ 323
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Frog   261 ADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKMKLTNNKGASNNNGQ 325

Human   324 MVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFA 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   326 MVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFA 390

Human   389 KGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGP 453
            |||||||||||||||:|||||||||||||||||||||:||.:||||||||||||:|||| .||.|
Frog   391 KGFRDNYDTIYTGCDLDRLTPSPNDSPRSQIVPGARYSMASTFLQDQFVSNYAKSRFHP-PGAVP 454

Human   454 GPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDF-AASAYDTATDFAGNAATLLSYA 517
            |||||||||||||||||||.|||||||||||||||||||||| :|||||.|||||||||||||||
Frog   455 GPGTDRSVPHTNGLLSPQQGEDPGAPSPQRWFVTPANNRLDFTSASAYDAATDFAGNAATLLSYA 519

Human   518 AAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYL 582
            |||||||||...|||.||||||:||:||||||||||| ||||||||||    |...|||..||||
Frog   520 AAGVKALPLPGGGCTARPLGYYSDPTGWGARSPPQYC-TKSGSVLPCW----ATGGRMAATNPYL 579

Human   583 --GEEAEGLAA-ERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPAD 644
              .||.|.||| :||||    .||.||||||||||||||.||||:|||||||||||||||:||:|
Frog   580 TGSEEVESLAATDRSPL----GEDTKPKDLSDSSWIETPPSIKSMDSSDSGIYEQAKRRRLSPSD 640

Human   645 TPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS 682
            ..||.|||||||||:..|||||||.||:| |||||:|:
Frog   641 PAVSGSSSPLKSEVVPPRDCEKNCTKDLS-YYGFYTHT 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		29/40 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		13/19 (68%)
		T-box_TBR1	203..393	CDD:410330	188/189 (99%)
		T-box_assoc	418..680	CDD:406561	212/265 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		31/35 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..658		54/70 (77%)
tbr1	NP_001072587.1	TBOX	205..398	CDD:238106	191/192 (99%)
tbr1	NP_001072587.1	T-box_assoc	420..675	CDD:292794	212/265 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I5742
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4807
Inparanoid	1	1.050	1188	1.000	Inparanoid score	I2273
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39493
OrthoDB	1	1.010	-	-		D101759at32523
OrthoFinder	1	1.000	-	-		FOG0011133
OrthoInspector	1	1.000	-	-		oto158477
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9299
SonicParanoid	1	1.000	-	-		X8720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110