Protein Alignment TBR1 and Doc1

DIOPT Version :9

• Sequence 1: NP_006584.1
• Gene: TBR1 / 10716
• HGNCID: 11590
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_648283.1
• Gene: Doc1 / 39039
• FlyBaseID: FBgn0028789
• Length: 391
• Species: Drosophila melanogaster
• Alignment Length: 472
• Identity: 146/472 - (30%)
• Similarity: 198/472 - (41%)
• Gaps: 133/472 - (28%)

Human   146 MAHHPVITNGAYNSLLSNSSPQGYPTAGYPY--PQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYL 208
            :||.      .|...:....|..:|:. .|:  |.|..|        ....::|.| || .:..|
  Fly    16 LAHE------IYRQQIMQRIPDPFPSM-LPFNMPHQQPH--------MMLPSRPTL-PG-VEAKL 63

Human   209 CNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVP 273
            .|..||.:||:..|||||||.||||||.:..::|||:..|.|.:.::::......::|.|.:|||
  Fly    64 ENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVP 128

Human   274 CGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLH 338
            .|.|:.. ...|:|:|||||.|||||..|.:.|.|:|||||...|:.:   :||.|:||||||||
  Fly   129 AGGAEPQ-SPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGH---IVLASMHKYQPRLH 189

Human   339 VVEVNEDGTEDTSQP-GRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGC 402
            ::.    .:|.|..| ...|.|.||||:|:|||||||..||:||||:||||||||::
  Fly   190 IIR----SSELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRES-------- 242

Human   403 DMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGL 467
            ...|.....|.|..|.:
  Fly   243 GQSRCKRKLNSSGNSTL------------------------------------------------ 259

Human   468 LSPQQAEDPGA-----PSPQRWFVTPANNRLDF-------AASAYDTATDFAGNAAT-----LLS 515
                ::||.|:     .|||     ....|.||       .:.||..||....|..:     .||
  Fly   260 ----ESEDDGSSVSSCDSPQ-----AKRQRQDFEQDSTGSVSPAYYGATHPVANPMSPYLRHHLS 315

Human   516 YAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANP 580
            |..:|...||...|.      .|:..       .|||        :||..|  |..|..:|..:|
  Fly   316 YGPSGAAGLPPSIAA------AYFGG-------VPPQ--------ILPMPP--ATYAPTVAPVSP 357

Human   581 YLGEEAEGLAAERSPLP 597
            ...:.........||.|
  Fly   358 VASQPVGSSTPTTSPRP 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..127
		T-box_TBR1	203..393	CDD:410330	93/190 (49%)
		T-box_assoc	418..680	CDD:406561	35/197 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..483		5/40 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	588..658		3/10 (30%)
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	95/203 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910